Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis

Kyung Yul Lee, Eun Hee Kim, Won Seok Yang, Hyunjeong Ryu, Sang Nae Cho, Byung In Lee, Ji Hoe Heo

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Matrix metalloproteinase (MMP)-2 and MMP-9 were analyzed by gelatin zymography and an enzyme-linked immunosorbent assay (ELISA) in a cerebrospinal fluid (CSF) from patients with tuberculous meningitis (n=24), acute aseptic meningitis (n=23) and the control (n=10). The MMP-2 and MMP-9 levels were significantly higher in the samples from the tuberculous meningitis patients than those from either the aseptic meningitis patients or the controls. In tuberculous meningitis, the patients with late neurologic complications had higher MMP-2 and MMP-9 levels than those without. The persistent increase in the MMP-2 and MMP-9 levels was associated with the development of complications following tuberculous meningitis. Inhibiting the MMPs may be an effective strategy for preventing or reducing the complications in tuberculous meningitis.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalJournal of the Neurological Sciences
Volume220
Issue number1-2
DOIs
Publication statusPublished - 2004 May 15

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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