Pesticide Exposure in Relation to the Incidence of Abnormal Glucose Regulation: A Retrospective Cohort Study

Sung Kyung Kim; Hyun Jung Oh; Sung Soo Oh; Sang Baek Koh

doi:10.3390/ijerph19127550

Pesticide Exposure in Relation to the Incidence of Abnormal Glucose Regulation: A Retrospective Cohort Study

Sung Kyung Kim, Hyun Jung Oh, Sung Soo Oh, Sang Baek Koh

Preventive medicine

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Diabetes and prediabetes (called abnormal glucose regulation (AGR)) are adverse health effects associated with exposure to pesticides. However, there are few epidemiological studies on the relationship between pesticide use and the incidence of AGR. We examined the causal relationship between pesticide use and AGR incidence in a rural population using data from a Korean Farmers’ Cohort study of 1076 participants. Poisson regression with robust error variance was used to calculate the relative risks (RR) and 95% confidence intervals (CI) to estimate the relationship between pesticide exposure and AGR. The incidence of AGR in the pesticide-exposed group was 29.1%. Pesticide use increased the RR of AGR (RR 1.32, 95% CI 1.03–1.69). We observed a low-dose effect related to exposure of pesticides to AGR and a U-shaped dose–response relationship in men. Pesticide exposure is related to the incidence of AGR, and the causal relationship differs between men and women.

Original language	English
Article number	7550
Journal	International journal of environmental research and public health
Volume	19
Issue number	12
DOIs	https://doi.org/10.3390/ijerph19127550
Publication status	Published - 2022 Jun 1

Bibliographical note

Funding Information:
Acknowledgments: This work was conducted with the support of the ‘Cooperative Research Program for the Development of Agriculture Science & Technology’ (Project No. PJ01250901), Rural Development Administration, Republic of Korea.

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/ijerph19127550

Cite this

@article{495a275936904ec991de68200264320d,

title = "Pesticide Exposure in Relation to the Incidence of Abnormal Glucose Regulation: A Retrospective Cohort Study",

abstract = "Diabetes and prediabetes (called abnormal glucose regulation (AGR)) are adverse health effects associated with exposure to pesticides. However, there are few epidemiological studies on the relationship between pesticide use and the incidence of AGR. We examined the causal relationship between pesticide use and AGR incidence in a rural population using data from a Korean Farmers{\textquoteright} Cohort study of 1076 participants. Poisson regression with robust error variance was used to calculate the relative risks (RR) and 95% confidence intervals (CI) to estimate the relationship between pesticide exposure and AGR. The incidence of AGR in the pesticide-exposed group was 29.1%. Pesticide use increased the RR of AGR (RR 1.32, 95% CI 1.03–1.69). We observed a low-dose effect related to exposure of pesticides to AGR and a U-shaped dose–response relationship in men. Pesticide exposure is related to the incidence of AGR, and the causal relationship differs between men and women.",

author = "Kim, {Sung Kyung} and Oh, {Hyun Jung} and Oh, {Sung Soo} and Koh, {Sang Baek}",

note = "Funding Information: Acknowledgments: This work was conducted with the support of the {\textquoteleft}Cooperative Research Program for the Development of Agriculture Science & Technology{\textquoteright} (Project No. PJ01250901), Rural Development Administration, Republic of Korea. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jun,

day = "1",

doi = "10.3390/ijerph19127550",

language = "English",

volume = "19",

journal = "International Journal of Environmental Research and Public Health",

issn = "1661-7827",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "12",

}

TY - JOUR

T1 - Pesticide Exposure in Relation to the Incidence of Abnormal Glucose Regulation

T2 - A Retrospective Cohort Study

AU - Kim, Sung Kyung

AU - Oh, Hyun Jung

AU - Oh, Sung Soo

AU - Koh, Sang Baek

N1 - Funding Information: Acknowledgments: This work was conducted with the support of the ‘Cooperative Research Program for the Development of Agriculture Science & Technology’ (Project No. PJ01250901), Rural Development Administration, Republic of Korea. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Diabetes and prediabetes (called abnormal glucose regulation (AGR)) are adverse health effects associated with exposure to pesticides. However, there are few epidemiological studies on the relationship between pesticide use and the incidence of AGR. We examined the causal relationship between pesticide use and AGR incidence in a rural population using data from a Korean Farmers’ Cohort study of 1076 participants. Poisson regression with robust error variance was used to calculate the relative risks (RR) and 95% confidence intervals (CI) to estimate the relationship between pesticide exposure and AGR. The incidence of AGR in the pesticide-exposed group was 29.1%. Pesticide use increased the RR of AGR (RR 1.32, 95% CI 1.03–1.69). We observed a low-dose effect related to exposure of pesticides to AGR and a U-shaped dose–response relationship in men. Pesticide exposure is related to the incidence of AGR, and the causal relationship differs between men and women.

AB - Diabetes and prediabetes (called abnormal glucose regulation (AGR)) are adverse health effects associated with exposure to pesticides. However, there are few epidemiological studies on the relationship between pesticide use and the incidence of AGR. We examined the causal relationship between pesticide use and AGR incidence in a rural population using data from a Korean Farmers’ Cohort study of 1076 participants. Poisson regression with robust error variance was used to calculate the relative risks (RR) and 95% confidence intervals (CI) to estimate the relationship between pesticide exposure and AGR. The incidence of AGR in the pesticide-exposed group was 29.1%. Pesticide use increased the RR of AGR (RR 1.32, 95% CI 1.03–1.69). We observed a low-dose effect related to exposure of pesticides to AGR and a U-shaped dose–response relationship in men. Pesticide exposure is related to the incidence of AGR, and the causal relationship differs between men and women.

UR - http://www.scopus.com/inward/record.url?scp=85132146663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85132146663&partnerID=8YFLogxK

U2 - 10.3390/ijerph19127550

DO - 10.3390/ijerph19127550

M3 - Article

C2 - 35742799

AN - SCOPUS:85132146663

SN - 1661-7827

VL - 19

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

IS - 12

M1 - 7550

ER -

Pesticide Exposure in Relation to the Incidence of Abnormal Glucose Regulation: A Retrospective Cohort Study

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this