pH-responsive hydrogel microparticles as intelligent delivery carriers for α-MSH antagonists

Juseung Yang, Geundo Cho, Tai Gyu Lee, Bumsang Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

For a first step in the development of an intelligent delivery system for a nonapeptide as an α-MSH antagonist, pH-responsive P(MAA-co-EGMA) hydrogel microparticles were prepared and their feasibility as intelligent delivery carriers was evaluated. There was a drastic change in the swelling ratio of P(MAA-co-EGMA) microparticles at a pH of around 5 and as the MAA amount in the hydrogel increased, the swelling ratio increased at a pH above 5. The loading efficiency of the nonapeptide at pH 7 increased with the amount of Methacrylic acid (MAA) in the hydrogel and at pH 2, where the electrostatic attraction was greatest, a high loading efficiency was not obtained because of the low swelling ratio of the hydrogel. The P(MAA-co-EGMA) microparticles demonstrated a pH-sensitive release behavior for the nonapeptide. In addition, the P(MAA-co-EGMA) microparticles showed a protective ability for the nonapeptide and preserved the stability of the nonapeptide.

Original languageEnglish
Pages (from-to)1919-1925
Number of pages7
JournalAICHE Journal
Volume57
Issue number7
DOIs
Publication statusPublished - 2011 Jul 1

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Melanocyte-Stimulating Hormones
Hydrogel
Hydrogels
Acids
Swelling
Static Electricity
methacrylic acid
Electrostatics

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Biotechnology
  • Environmental Engineering

Cite this

Yang, Juseung ; Cho, Geundo ; Lee, Tai Gyu ; Kim, Bumsang. / pH-responsive hydrogel microparticles as intelligent delivery carriers for α-MSH antagonists. In: AICHE Journal. 2011 ; Vol. 57, No. 7. pp. 1919-1925.
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pH-responsive hydrogel microparticles as intelligent delivery carriers for α-MSH antagonists. / Yang, Juseung; Cho, Geundo; Lee, Tai Gyu; Kim, Bumsang.

In: AICHE Journal, Vol. 57, No. 7, 01.07.2011, p. 1919-1925.

Research output: Contribution to journalArticle

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