Phagocyte-myocyte interactions and consequences during hypoxic wound healing

Shuang Zhang, Shirley Dehn, Matthew DeBerge, Kijong Rhee, Barry Hudson, Edward B. Thorp

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Myocardial infarction (MI), secondary to atherosclerotic plaque rupture and occlusive thrombi, triggers acute margination of inflammatory neutrophils and monocyte phagocyte subsets to the damaged heart, the latter of which may give rise briefly to differentiated macrophage-like or dendritic-like cells. Within the injured myocardium, a primary function of these phagocytic cells is to remove damaged extracellular matrix, necrotic and apoptotic cardiac cells, as well as immune cells that turn over. Recognition of dying cellular targets by phagocytes triggers intracellular signaling, particularly in macrophages, wherein cytokines and lipid mediators are generated to promote inflammation resolution, fibrotic scarring, angiogenesis, and compensatory organ remodeling. These actions cooperate in an effort to preserve myocardial contractility and prevent heart failure. Immune cell function is modulated by local tissue factors that include secreted protease activity, oxidative stress during clinical reperfusion, and hypoxia. Importantly, experimental evidence suggests that monocyte function and phagocytosis efficiency is compromised in the setting of MI risk factors, including hyperlipidemia and ageing, however underlying mechanisms remain unclear. Herein we review seminal phagocyte and cardiac molecular factors that lead to, and culminate in, the recognition and removal of dying injured myocardium, the effects of hypoxia, and their relationship to cardiac infarct size and heart healing.

Original languageEnglish
Pages (from-to)65-73
Number of pages9
JournalCellular Immunology
Volume291
Issue number1-2
DOIs
Publication statusPublished - 2014 Sep 1

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Phagocytes
Wound Healing
Muscle Cells
Monocytes
Myocardium
Macrophages
Myocardial Infarction
Thromboplastin
Atherosclerotic Plaques
Hyperlipidemias
Phagocytosis
Dendritic Cells
Reperfusion
Cicatrix
Extracellular Matrix
Rupture
Oxidative Stress
Neutrophils
Thrombosis
Peptide Hydrolases

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Zhang, Shuang ; Dehn, Shirley ; DeBerge, Matthew ; Rhee, Kijong ; Hudson, Barry ; Thorp, Edward B. / Phagocyte-myocyte interactions and consequences during hypoxic wound healing. In: Cellular Immunology. 2014 ; Vol. 291, No. 1-2. pp. 65-73.
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Phagocyte-myocyte interactions and consequences during hypoxic wound healing. / Zhang, Shuang; Dehn, Shirley; DeBerge, Matthew; Rhee, Kijong; Hudson, Barry; Thorp, Edward B.

In: Cellular Immunology, Vol. 291, No. 1-2, 01.09.2014, p. 65-73.

Research output: Contribution to journalArticle

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