Phagocytic activity of ethyl alcohol fraction of deer antler in murine peritoneal macrophage

Jeong Sook Suh, Jae Soon Eun, June No So, Jeong Taeg Seo, Gil Ja Jhon

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26 Citations (Scopus)

Abstract

The mechanism of phagocytic activity of the ethyl alcohol fraction of Cervus nippon (CN-E) was investigated in vivo. The administration of CN-E (100 mg/kg, p.o.) enhanced lucigenin chemiluminescence and the engulfment of fluorescein-conjugated E. coli particles in murine peritoneal macrophages. Phagocytic activity was suppressed by the treatment of S-nitrosoglutathione (GSNO) which is an exogenous nitric oxide donor depending on the concentration of dose. CN-E suppressed the production of nitric oxide and enhanced the concentration in [Ca2+](i). The enhancement in [Ca2+](i) was diminished by the treatment of EGTA. These results indicate that CN-E enhances the phagocytic activity of murine peritoneal macrophage via a suppression of nitric oxide production and an increase in [Ca2+](i).

Original languageEnglish
Pages (from-to)932-935
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume22
Issue number9
DOIs
Publication statusPublished - 1999 Sep

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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