Pharmacokinetic alteration of baclofen by multiple oral administration of herbal medicines in rats

Tae Hwan Kim, Gi Young Park, Soyoung Shin, Dong Rak Kwon, Won Sik Seo, Jeong Cheol Shin, Jin Ho Choi, Sang Hoon Joo, Kwon Yeon Weon, Byung Sun Min, Kyung Min Baek, Mahesh Upadhyay, Bing Tian Zhao, Mi Hee Woo, So Hee Kwon, Beom Soo Shin

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6 Citations (Scopus)

Abstract

The potential pharmacokinetic (PK) interaction of conventional western drug, baclofen, and oriental medications Oyaksungisan (OY) and Achyranthes bidentata radix (AB) extract for the treatment of spasticity has been evaluated. Rats were pretreated with distilled water (DW), OY, or AB extract by oral administration every day for 7 days. After 10 min of the final dose of DW or each herbal medication, baclofen (1 mg/kg) was given by oral administration and plasma concentrations of baclofen were determined by LC/MS/MS. The plasma baclofen concentration-time profiles were then analyzed by noncompartmental analysis and a population PK model was developed. Baclofen was rapidly absorbed, showed biexponential decline with elimination half-life of 3.42-4.10 hr, and mostly excreted into urine. The PK of baclofen was not affected by AB extract pretreatment. However, significantly lower maximum plasma concentration (C max) and longer time to reach C max (T max) were observed in OY pretreated rats without changes in the area under the curve (AUC) and the fraction excreted into urine (F urine). The absorption rate (K a) of baclofen was significantly decreased in OY pretreated rats. These data suggested that repeated doses of OY might delay the absorption of baclofen without changes in extent of absorption, which needs further evaluation for clinical significance.

Original languageEnglish
Article number402126
JournalEvidence-based Complementary and Alternative Medicine
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Baclofen
Herbal Medicine
Oral Administration
Pharmacokinetics
Achyranthes
Urine
Water
Area Under Curve
Half-Life

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine

Cite this

Kim, Tae Hwan ; Park, Gi Young ; Shin, Soyoung ; Kwon, Dong Rak ; Seo, Won Sik ; Shin, Jeong Cheol ; Choi, Jin Ho ; Joo, Sang Hoon ; Weon, Kwon Yeon ; Min, Byung Sun ; Baek, Kyung Min ; Upadhyay, Mahesh ; Zhao, Bing Tian ; Woo, Mi Hee ; Kwon, So Hee ; Shin, Beom Soo. / Pharmacokinetic alteration of baclofen by multiple oral administration of herbal medicines in rats. In: Evidence-based Complementary and Alternative Medicine. 2014 ; Vol. 2014.
@article{c32739304f25484e9ddb4063ea3fda20,
title = "Pharmacokinetic alteration of baclofen by multiple oral administration of herbal medicines in rats",
abstract = "The potential pharmacokinetic (PK) interaction of conventional western drug, baclofen, and oriental medications Oyaksungisan (OY) and Achyranthes bidentata radix (AB) extract for the treatment of spasticity has been evaluated. Rats were pretreated with distilled water (DW), OY, or AB extract by oral administration every day for 7 days. After 10 min of the final dose of DW or each herbal medication, baclofen (1 mg/kg) was given by oral administration and plasma concentrations of baclofen were determined by LC/MS/MS. The plasma baclofen concentration-time profiles were then analyzed by noncompartmental analysis and a population PK model was developed. Baclofen was rapidly absorbed, showed biexponential decline with elimination half-life of 3.42-4.10 hr, and mostly excreted into urine. The PK of baclofen was not affected by AB extract pretreatment. However, significantly lower maximum plasma concentration (C max) and longer time to reach C max (T max) were observed in OY pretreated rats without changes in the area under the curve (AUC) and the fraction excreted into urine (F urine). The absorption rate (K a) of baclofen was significantly decreased in OY pretreated rats. These data suggested that repeated doses of OY might delay the absorption of baclofen without changes in extent of absorption, which needs further evaluation for clinical significance.",
author = "Kim, {Tae Hwan} and Park, {Gi Young} and Soyoung Shin and Kwon, {Dong Rak} and Seo, {Won Sik} and Shin, {Jeong Cheol} and Choi, {Jin Ho} and Joo, {Sang Hoon} and Weon, {Kwon Yeon} and Min, {Byung Sun} and Baek, {Kyung Min} and Mahesh Upadhyay and Zhao, {Bing Tian} and Woo, {Mi Hee} and Kwon, {So Hee} and Shin, {Beom Soo}",
year = "2014",
doi = "10.1155/2014/402126",
language = "English",
volume = "2014",
journal = "Evidence-based Complementary and Alternative Medicine",
issn = "1741-427X",
publisher = "Hindawi Publishing Corporation",

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Kim, TH, Park, GY, Shin, S, Kwon, DR, Seo, WS, Shin, JC, Choi, JH, Joo, SH, Weon, KY, Min, BS, Baek, KM, Upadhyay, M, Zhao, BT, Woo, MH, Kwon, SH & Shin, BS 2014, 'Pharmacokinetic alteration of baclofen by multiple oral administration of herbal medicines in rats', Evidence-based Complementary and Alternative Medicine, vol. 2014, 402126. https://doi.org/10.1155/2014/402126

Pharmacokinetic alteration of baclofen by multiple oral administration of herbal medicines in rats. / Kim, Tae Hwan; Park, Gi Young; Shin, Soyoung; Kwon, Dong Rak; Seo, Won Sik; Shin, Jeong Cheol; Choi, Jin Ho; Joo, Sang Hoon; Weon, Kwon Yeon; Min, Byung Sun; Baek, Kyung Min; Upadhyay, Mahesh; Zhao, Bing Tian; Woo, Mi Hee; Kwon, So Hee; Shin, Beom Soo.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2014, 402126, 2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pharmacokinetic alteration of baclofen by multiple oral administration of herbal medicines in rats

AU - Kim, Tae Hwan

AU - Park, Gi Young

AU - Shin, Soyoung

AU - Kwon, Dong Rak

AU - Seo, Won Sik

AU - Shin, Jeong Cheol

AU - Choi, Jin Ho

AU - Joo, Sang Hoon

AU - Weon, Kwon Yeon

AU - Min, Byung Sun

AU - Baek, Kyung Min

AU - Upadhyay, Mahesh

AU - Zhao, Bing Tian

AU - Woo, Mi Hee

AU - Kwon, So Hee

AU - Shin, Beom Soo

PY - 2014

Y1 - 2014

N2 - The potential pharmacokinetic (PK) interaction of conventional western drug, baclofen, and oriental medications Oyaksungisan (OY) and Achyranthes bidentata radix (AB) extract for the treatment of spasticity has been evaluated. Rats were pretreated with distilled water (DW), OY, or AB extract by oral administration every day for 7 days. After 10 min of the final dose of DW or each herbal medication, baclofen (1 mg/kg) was given by oral administration and plasma concentrations of baclofen were determined by LC/MS/MS. The plasma baclofen concentration-time profiles were then analyzed by noncompartmental analysis and a population PK model was developed. Baclofen was rapidly absorbed, showed biexponential decline with elimination half-life of 3.42-4.10 hr, and mostly excreted into urine. The PK of baclofen was not affected by AB extract pretreatment. However, significantly lower maximum plasma concentration (C max) and longer time to reach C max (T max) were observed in OY pretreated rats without changes in the area under the curve (AUC) and the fraction excreted into urine (F urine). The absorption rate (K a) of baclofen was significantly decreased in OY pretreated rats. These data suggested that repeated doses of OY might delay the absorption of baclofen without changes in extent of absorption, which needs further evaluation for clinical significance.

AB - The potential pharmacokinetic (PK) interaction of conventional western drug, baclofen, and oriental medications Oyaksungisan (OY) and Achyranthes bidentata radix (AB) extract for the treatment of spasticity has been evaluated. Rats were pretreated with distilled water (DW), OY, or AB extract by oral administration every day for 7 days. After 10 min of the final dose of DW or each herbal medication, baclofen (1 mg/kg) was given by oral administration and plasma concentrations of baclofen were determined by LC/MS/MS. The plasma baclofen concentration-time profiles were then analyzed by noncompartmental analysis and a population PK model was developed. Baclofen was rapidly absorbed, showed biexponential decline with elimination half-life of 3.42-4.10 hr, and mostly excreted into urine. The PK of baclofen was not affected by AB extract pretreatment. However, significantly lower maximum plasma concentration (C max) and longer time to reach C max (T max) were observed in OY pretreated rats without changes in the area under the curve (AUC) and the fraction excreted into urine (F urine). The absorption rate (K a) of baclofen was significantly decreased in OY pretreated rats. These data suggested that repeated doses of OY might delay the absorption of baclofen without changes in extent of absorption, which needs further evaluation for clinical significance.

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