Pharmacokinetic modeling of phagocytic activity of the liver using superparamagnetic iron oxide nanoparticles in dynamic MR imaging

Jae Boem Na, Jinsuck Suh, yongmin Huh, Sung Joon Kim, Seung Hyung Kim, Seung Whan Cha, Sang Hoon Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The purpose of this study was to determine whether phagocytic activity is measurable by dynamic superparamagnetic iron oxide-enhanced MR imaging. For these experiments on New Zealand White rabbits, which were randomly allocated to normal and silica treated groups, we performed a dynamic MR study and radioisotope study with Tc 99m -phytate. In this dynamic MR study, the ratio (Rv) of the distribution volumes of iron oxide (Vm/Ve) could be obtained by applying three-compartment model to the data obtained from the kidney and liver simultaneously. Changes in Rv caused by silica injection and by dosing superparamagnetic iron oxide, AMI-25, were evaluated. In the dynamic MR study using a Beagle dog model the input function could be calculated from data obtained from the hepatic artery and portal vein. Rv's reached maxinium values at around 80 minutes after the AMI-25 injection. The Rv of the normal group was 5.06 ± 1.53 whereas the Rv of the silica treated group was 2.13 ± 1.20. The results were similar to tissue count data obtained by radioisope study. The Rv value was not dependent on the injected dose of AMI-25. The rate of transport constants (k1, k2, k3) could not be estimated using the 3 compartment model regardless of obtaining the input function. We conclude that Rv may be an quantitative index of decreased phagocytic activity in the liver as determined by dynamic superparamagnetic iron oxide-enhanced MRI.

Original languageEnglish
Pages (from-to)429-437
Number of pages9
JournalYonsei medical journal
Volume44
Issue number3
DOIs
Publication statusPublished - 2003 Jun 30

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Nanoparticles
Pharmacokinetics
Silicon Dioxide
Liver
Injections
Hepatic Veins
Hepatic Artery
Portal Vein
Radioisotopes
Dogs
Rabbits
Kidney
ferric oxide
ferumoxides

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Na, Jae Boem ; Suh, Jinsuck ; Huh, yongmin ; Kim, Sung Joon ; Kim, Seung Hyung ; Cha, Seung Whan ; Lee, Sang Hoon. / Pharmacokinetic modeling of phagocytic activity of the liver using superparamagnetic iron oxide nanoparticles in dynamic MR imaging. In: Yonsei medical journal. 2003 ; Vol. 44, No. 3. pp. 429-437.
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Pharmacokinetic modeling of phagocytic activity of the liver using superparamagnetic iron oxide nanoparticles in dynamic MR imaging. / Na, Jae Boem; Suh, Jinsuck; Huh, yongmin; Kim, Sung Joon; Kim, Seung Hyung; Cha, Seung Whan; Lee, Sang Hoon.

In: Yonsei medical journal, Vol. 44, No. 3, 30.06.2003, p. 429-437.

Research output: Contribution to journalArticle

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AU - Na, Jae Boem

AU - Suh, Jinsuck

AU - Huh, yongmin

AU - Kim, Sung Joon

AU - Kim, Seung Hyung

AU - Cha, Seung Whan

AU - Lee, Sang Hoon

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