Pharmacokinetic profile and anti-adhesive effect of oxaliplatin-PLGA microparticle-loaded hydrogels in rats for colorectal cancer treatment

Sharif Md Abuzar, Jun Hyun Ahn, Kyung Su Park, Eun Jung Park, Seung Hyuk Baik, Sung Joo Hwang

Research output: Contribution to journalArticle

Abstract

Colorectal cancer (CRC) is one of the most malignant and fatal cancers worldwide. Although cytoreductive surgery combined with chemotherapy is considered a promising therapy, peritoneal adhesion causes further complications after surgery. In this study, oxaliplatin-loaded Poly-(d,l-lactide-co-glycolide) (PLGA) microparticles were prepared using a double emulsion method and loaded into hyaluronic acid (HA)-and carboxymethyl cellulose sodium (CMCNa)-based cross-linked (HC) hydrogels. From characterization and evaluation study PLGA microparticles showed smaller particle size with higher entrapment efficiency, approximately 1100.4 ± 257.7 nm and 77.9 ± 2.8%, respectively. In addition, microparticle-loaded hydrogels showed more sustained drug release compared to the unloaded microparticles. Moreover, in an in vivo pharmacokinetic study after intraperitoneal administration in rats, a significant improvement in the bioavailability and the mean residence time of the microparticle-loaded hydrogels was observed. In HC21 hydrogels, AUC0–48h, Cmax, and Tmax were 16012.12 ± 188.75 ng·h/mL, 528.75 ± 144.50 ng/mL, and 1.5 h, respectively. Furthermore, experimental observation revealed that the hydrogel samples effectively protected injured tissues from peritoneal adhesion. Therefore, the results of the current pharmacokinetic study together with our previous report of the in vivo anti-adhesion efficacy of HC hydrogels demonstrated that the PLGA microparticle-loaded hydrogels offer novel therapeutic strategy for CRC treatment.

Original languageEnglish
Article number392
JournalPharmaceutics
Volume11
Issue number8
DOIs
Publication statusPublished - 2019 Aug

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oxaliplatin
Hydrogels
Adhesives
Colorectal Neoplasms
Pharmacokinetics
Therapeutics
Tissue Adhesions
Carboxymethylcellulose Sodium
Hydrogel
Hyaluronic Acid
Emulsions
Particle Size
Biological Availability
polylactic acid-polyglycolic acid copolymer
Sodium
Observation

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Abuzar, Sharif Md ; Ahn, Jun Hyun ; Park, Kyung Su ; Park, Eun Jung ; Baik, Seung Hyuk ; Hwang, Sung Joo. / Pharmacokinetic profile and anti-adhesive effect of oxaliplatin-PLGA microparticle-loaded hydrogels in rats for colorectal cancer treatment. In: Pharmaceutics. 2019 ; Vol. 11, No. 8.
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Pharmacokinetic profile and anti-adhesive effect of oxaliplatin-PLGA microparticle-loaded hydrogels in rats for colorectal cancer treatment. / Abuzar, Sharif Md; Ahn, Jun Hyun; Park, Kyung Su; Park, Eun Jung; Baik, Seung Hyuk; Hwang, Sung Joo.

In: Pharmaceutics, Vol. 11, No. 8, 392, 08.2019.

Research output: Contribution to journalArticle

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AU - Abuzar, Sharif Md

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AU - Baik, Seung Hyuk

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