Pharmacokinetic properties and tissue storage of FITC conjugated SA-MnMEIO nanoparticles in mice

Yeong Shin Yim, Jin sil Choi, Seong Bok Jang, Gun Tae Kim, Kyungsoo Park, Chul Hoon Kim, Jinwoo Cheon, Dong Goo Kim

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Abstract

Nowadays, attempts to use nanoparticles for medical applications are on the rise. However, the effect of nanoparticles in the body has not been clarified. In this study, we aimed to examine the pharmacokinetics of magnetized nanoparticles. FITC conjugated SA-MnMEIO nanoparticles were prepared for the purpose of tracing. Nanoparticles (15 nm diameter) were injected into the tail vein of BALB/c mice at a dose of 20 mg (Mn+Fe)/kg. A mouse was housed in a metabolic cage and sacrificed serially up to 14 days for the sampling of blood and tissues from various organs (i.e., heart, kidney, liver, and spleen). The concentration of nanoparticles was measured by detecting FITC using spectrofluorophotometer. Nanoparticles showed a half-life of 8.20 h. The fluorescence intensities of nanoparticles in tissues showed different time-dependent patterns among different organs. In the heart and the liver, the fluorescence intensities increased up to 2 weeks of observation, while those in the kidney and the spleen decreased. The results indicate that nanoparticles have unique pharmacokinetic characteristics and suggest that pharmacokinetic study is essential for the development of new nanoparticles for medical use.

Original languageEnglish
Pages (from-to)e304-e307
JournalCurrent Applied Physics
Volume9
Issue number4 SUPPL.
DOIs
Publication statusPublished - 2009 Jul 1

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Physics and Astronomy(all)

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    Yim, Y. S., Choi, J. S., Jang, S. B., Kim, G. T., Park, K., Kim, C. H., Cheon, J., & Kim, D. G. (2009). Pharmacokinetic properties and tissue storage of FITC conjugated SA-MnMEIO nanoparticles in mice. Current Applied Physics, 9(4 SUPPL.), e304-e307. https://doi.org/10.1016/j.cap.2009.06.033