Pharmacokinetics and correlation analysis of cilostazol in healthy Korean subjects

Hye Duck Choi, Hye Jung Lee, Sang Hun Lee, Soo Hwan Kim, Chung Am Choi, Min Jung Chang, Wan Gyoon Shin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Cilostazol is frequently used to treat and prevent thrombosis in Korean patients. Patients and methods: We performed the pharmacokinetic and correlation analysis of cilostazol in Korean healthy subjects. A total of male 78 volunteers was subjected to three separate bioequivalence studies in which 100 mg of cilostazol was administered. AUC, t 1/2, and C max were 12,100 ± 4,880 ngxh/ml, 11.1 ± 4.4 hours, and 827 ± 361 ng/ml, respectively. Results: ALT was positively correlated with age and C max was positively correlated with AUC, but negatively correlated with body weight. Conclusion: We suggest that the unique pharmacokinetic parameters and interrelationship can help to understand the pharmacokinetics of cilostazol in Korean subjects.

Original languageEnglish
Pages (from-to)345-348
Number of pages4
JournalInternational Journal of Clinical Pharmacology and Therapeutics
Volume50
Issue number5
DOIs
Publication statusPublished - 2012 May 1

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this