We evaluated whether the pharmacokinetic parameters of indinavir differ in Koreans and Caucasians. Indinavir was administered orally to 8 healthy Koreans and 4 healthy Caucasians, and plasma indinavir levels were quantified by high performance liquid chromatography. No significant differences were observed in terms of its pharmacokinetic parameters; however, the AUC difference between the 2 groups may be significant for larger sample sizes.
Bibliographical noteFunding Information:
This study was supported by the BK21 Project for Medical Sciences, Yonsei University.
All Science Journal Classification (ASJC) codes
- Immunology and Microbiology(all)
- Microbiology (medical)
- Infectious Diseases