Pharmacophore-based virtual screening: The discovery of novel methionyl-tRNA synthetase inhibitors

Su Yeon Kim, Yeon Sook Lee, Taehee Kang, Sunghoon Kim, Jeewoo Lee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We have performed virtual screening of a chemical database of 508,143 commercially available chemicals to search for new methionyl-tRNA synthetase (MetRS) inhibitors. In this study, potent lead compounds with a novel skeleton, including compound 27 with IC50 = 237 nM, were successfully identified as Escherichia coli MetRS inhibitors.

Original languageEnglish
Pages (from-to)4898-4907
Number of pages10
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number18
DOIs
Publication statusPublished - 2006 Sep 15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Pharmacophore-based virtual screening: The discovery of novel methionyl-tRNA synthetase inhibitors'. Together they form a unique fingerprint.

  • Cite this