TY - JOUR
T1 - PharmDB-K
T2 - Integrated bio-pharmacological network database for traditional Korean medicine
AU - Lee, Ji Hyun
AU - Park, Kyoung Mii
AU - Han, Dong Jin
AU - Bang, Nam Young
AU - Kim, Do Hee
AU - Na, Hyeongjin
AU - Lim, Semi
AU - Kim, Tae Bum
AU - Kim, Dae Gyu
AU - Kim, Hyun Jung
AU - Chung, Yeonseok
AU - Sung, Sang Hyun
AU - Surh, Young Joon
AU - Kim, Sunghoon
AU - Han, Byung Woo
PY - 2015/11/10
Y1 - 2015/11/10
N2 - Despite the growing attention given to Traditional Medicine (TM) worldwide, there is no wellknown, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensive information relating to TKM-Associated drugs (compound), disease indication, and protein relationships. To explore the underlying molecular interaction of TKM, we integrated fourteen different databases, six Pharmacopoeias, and literature, and established a massive bio-pharmacological network for TKM and experimentally validated some cases predicted from the PharmDB-K analyses. Currently, PharmDB-K contains information about 262 TKMs, 7,815 drugs, 3,721 diseases, 32,373 proteins, and 1,887 side effects. One of the unique sets of information in PharmDB-K includes 400 indicator compounds used for standardization of herbal medicine. Furthermore, we are operating PharmDB-K via phExplorer (a network visualization software) and BioMart (a data federation framework) for convenient search and analysis of the TKM network.
AB - Despite the growing attention given to Traditional Medicine (TM) worldwide, there is no wellknown, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensive information relating to TKM-Associated drugs (compound), disease indication, and protein relationships. To explore the underlying molecular interaction of TKM, we integrated fourteen different databases, six Pharmacopoeias, and literature, and established a massive bio-pharmacological network for TKM and experimentally validated some cases predicted from the PharmDB-K analyses. Currently, PharmDB-K contains information about 262 TKMs, 7,815 drugs, 3,721 diseases, 32,373 proteins, and 1,887 side effects. One of the unique sets of information in PharmDB-K includes 400 indicator compounds used for standardization of herbal medicine. Furthermore, we are operating PharmDB-K via phExplorer (a network visualization software) and BioMart (a data federation framework) for convenient search and analysis of the TKM network.
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U2 - 10.1371/journal.pone.0142624
DO - 10.1371/journal.pone.0142624
M3 - Article
C2 - 26555441
AN - SCOPUS:84953256520
VL - 10
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 11
M1 - e0142624
ER -