Abstract
Background Dacomitinib is a second-generation, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). Pre-clinical data suggest that intermittent pulsatile dosing of dacomitinib may result in inhibition of EGFR T790M. Methods We evaluated safety, pharmacokinetics and efficacy of intermittent pulsatile dacomitinib in both molecularly unselected patients and patients with lung cancers harboring EGFR T790M (Clinical Trial Registration Number NCT01858389). Results Thirty-eight patients were treated on study with pulse dacomitinib; sixteen with EGFR T790M in Cohort A and 22 who were not molecularly selected in Cohort B. One patient out of 16 patients in Cohort A had a partial response to study therapy (ORR 6.3%, 95% CI 0.2-30.2%). The median progression-free survival (PFS) in Cohort A was 2.3 months and median PFS in Cohort B was 1.6 months. The adverse event profile was similar to standard daily dose dacomitinib with the most frequent treatment-related toxicities occurring in >20% of patients being diarrhea, rash, stomatitis, nausea, dry skin, paronychia, fatigue, and decreased appetite. Conclusion Intermittent pulsatile dacomitinib is safe and relatively well tolerated but is not effective in patients that harbor EGFR T790M or in unselected patients with non-small cell lung cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 195-199 |
| Number of pages | 5 |
| Journal | Lung Cancer |
| Volume | 112 |
| DOIs | |
| Publication status | Published - 2017 Oct |
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All Science Journal Classification (ASJC) codes
- Oncology
- Pulmonary and Respiratory Medicine
- Cancer Research
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Phase 2 study of intermittent pulse dacomitinib in patients with advanced non-small cell lung cancers. / Yu, Helena A.; Ahn, Myung Ju; Cho, Byoung Chul; Gerber, David E.; Natale, Ronald B.; Socinski, Mark A.; Giri, Nagdeep; Quinn, Susan; Sbar, Eric; Zhang, Hui; Giaccone, Giuseppe.
In: Lung Cancer, Vol. 112, 10.2017, p. 195-199.Research output: Contribution to journal › Article
TY - JOUR
T1 - Phase 2 study of intermittent pulse dacomitinib in patients with advanced non-small cell lung cancers
AU - Yu, Helena A.
AU - Ahn, Myung Ju
AU - Cho, Byoung Chul
AU - Gerber, David E.
AU - Natale, Ronald B.
AU - Socinski, Mark A.
AU - Giri, Nagdeep
AU - Quinn, Susan
AU - Sbar, Eric
AU - Zhang, Hui
AU - Giaccone, Giuseppe
PY - 2017/10
Y1 - 2017/10
N2 - Background Dacomitinib is a second-generation, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). Pre-clinical data suggest that intermittent pulsatile dosing of dacomitinib may result in inhibition of EGFR T790M. Methods We evaluated safety, pharmacokinetics and efficacy of intermittent pulsatile dacomitinib in both molecularly unselected patients and patients with lung cancers harboring EGFR T790M (Clinical Trial Registration Number NCT01858389). Results Thirty-eight patients were treated on study with pulse dacomitinib; sixteen with EGFR T790M in Cohort A and 22 who were not molecularly selected in Cohort B. One patient out of 16 patients in Cohort A had a partial response to study therapy (ORR 6.3%, 95% CI 0.2-30.2%). The median progression-free survival (PFS) in Cohort A was 2.3 months and median PFS in Cohort B was 1.6 months. The adverse event profile was similar to standard daily dose dacomitinib with the most frequent treatment-related toxicities occurring in >20% of patients being diarrhea, rash, stomatitis, nausea, dry skin, paronychia, fatigue, and decreased appetite. Conclusion Intermittent pulsatile dacomitinib is safe and relatively well tolerated but is not effective in patients that harbor EGFR T790M or in unselected patients with non-small cell lung cancer.
AB - Background Dacomitinib is a second-generation, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). Pre-clinical data suggest that intermittent pulsatile dosing of dacomitinib may result in inhibition of EGFR T790M. Methods We evaluated safety, pharmacokinetics and efficacy of intermittent pulsatile dacomitinib in both molecularly unselected patients and patients with lung cancers harboring EGFR T790M (Clinical Trial Registration Number NCT01858389). Results Thirty-eight patients were treated on study with pulse dacomitinib; sixteen with EGFR T790M in Cohort A and 22 who were not molecularly selected in Cohort B. One patient out of 16 patients in Cohort A had a partial response to study therapy (ORR 6.3%, 95% CI 0.2-30.2%). The median progression-free survival (PFS) in Cohort A was 2.3 months and median PFS in Cohort B was 1.6 months. The adverse event profile was similar to standard daily dose dacomitinib with the most frequent treatment-related toxicities occurring in >20% of patients being diarrhea, rash, stomatitis, nausea, dry skin, paronychia, fatigue, and decreased appetite. Conclusion Intermittent pulsatile dacomitinib is safe and relatively well tolerated but is not effective in patients that harbor EGFR T790M or in unselected patients with non-small cell lung cancer.
UR - http://www.scopus.com/inward/record.url?scp=85028558346&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028558346&partnerID=8YFLogxK
U2 - 10.1016/j.lungcan.2017.08.017
DO - 10.1016/j.lungcan.2017.08.017
M3 - Article
C2 - 29191595
AN - SCOPUS:85028558346
VL - 112
SP - 195
EP - 199
JO - Lung Cancer
JF - Lung Cancer
SN - 0169-5002
ER -