Phase I trial of neoadjuvant concurrent chemoradiotherapy with S-1 and weekly irinotecan in locally advanced rectal cancer

Hye Jin Choi, Nam Kyu Kim, Ki Chang Keum, Seong Ha Cheon, Sang Jun Shin, Seung Hyuk Baik, Jae Hee Choen, Sun Young Rha, Jae Kyung Roh, Hei Cheul Jeung, Hyun Cheol Chung, Joong Bae Ahn

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

S-1 is a novel, oral fluoropyrimidine and a known radiosensitizer. We conducted a phase I trial to establish a schedule of S-1/irinotecan with standard pelvic radiotherapy as a preoperative treatment of locally advanced rectal cancer. Our findings suggest that this new combination is feasible and well tolerable.

Original languageEnglish
Pages (from-to)361-366
Number of pages6
JournalRadiotherapy and Oncology
Volume87
Issue number3
DOIs
Publication statusPublished - 2008 Jun 1

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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