Phenolics and neolignans isolated from the fruits of Juglans mandshurica Maxim. and their effects on lipolysis in adipocytes

Seon Ju Park, Nanyoung Kim, Guijae Yoo, Sang Nam Kim, Hyun Jung Kwon, Kiwon Jung, Dong Chan Oh, Yun Hee Lee, Seung Hyun Kim

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Juglans mandshurica Maxim. (Juglandaceae) is a traditional folk medicine used for treatment of dermatosis and to relieve aches in Korea and China. In this study, eight compounds, along with six known compounds, were isolated from the fruit of J. mandshurica. Among the six known compounds, the absolute configuration of two compounds were determined. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. All isolated compounds were tested for their lipolytic activities in differentiated adipocytes using C3H10T1/2 mouse embryonic fibroblasts. Among them, 2-(4-formyl-2-methoxyphenoxy)-propan-1,3-diol and 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-1,3-propanediol exhibited the most potent lipolytic activities.

Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalPhytochemistry
Volume137
DOIs
Publication statusPublished - 2017 May 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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