Phenotype of peroxisome proliferator-activated receptor-alpha(PPARalpha)deficient mice on mixed background fed high fat diet.

Bang Hyun Kim, Young Suk Won, Eun Young Kim, Mijung Yoon, Ki Taek Nam, Goo Taeg Oh, Dae Yong Kim

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-alpha PPARalpha) on obesity. Previous reports demonstrated that PPARalpha is a critical modulator of lipid homeostasis, but the overt, obese phenotypic characterization in the strain of PPAR deficient (PPARalpha-/-) mice is influenced by other factors, including diet and genetics. Therefore, it is necessary to establish the phenotypic characterization of PPARalpha-/- mice prior to the obesity-related study. In this study, we observed phenotype of PPARalpha-/- mice on mixed genetic background (C57BL/6Nx129/Sv) fed a high fat diet for 16 weeks. PPARalpha-/- mice, regardless of sex, raised body growth rate significantly comparing with wild type and showed male-specific fatty change in the liver. They were shown to lack hepatic induction of PPARalpha target genes encoding enzymes for fatty acid beta-oxidation.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalJournal of veterinary science (Suwon-si, Korea)
Volume4
Issue number3
DOIs
Publication statusPublished - 2003 Dec

All Science Journal Classification (ASJC) codes

  • veterinary(all)

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