Phenotype of peroxisome proliferator-activated receptor-alpha(PPARalpha)deficient mice on mixed background fed high fat diet.

Bang Hyun Kim, Young Suk Won, Eun Young Kim, Mijung Yoon, KiTaek Nam, Goo Taeg Oh, Dae Yong Kim

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-alpha PPARalpha) on obesity. Previous reports demonstrated that PPARalpha is a critical modulator of lipid homeostasis, but the overt, obese phenotypic characterization in the strain of PPAR deficient (PPARalpha-/-) mice is influenced by other factors, including diet and genetics. Therefore, it is necessary to establish the phenotypic characterization of PPARalpha-/- mice prior to the obesity-related study. In this study, we observed phenotype of PPARalpha-/- mice on mixed genetic background (C57BL/6Nx129/Sv) fed a high fat diet for 16 weeks. PPARalpha-/- mice, regardless of sex, raised body growth rate significantly comparing with wild type and showed male-specific fatty change in the liver. They were shown to lack hepatic induction of PPARalpha target genes encoding enzymes for fatty acid beta-oxidation.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalJournal of veterinary science (Suwon-si, Korea)
Volume4
Issue number3
Publication statusPublished - 2003 Jan 1

Fingerprint

PPAR alpha
High Fat Diet
high fat diet
Phenotype
phenotype
mice
obesity
Obesity
liver
Peroxisome Proliferator-Activated Receptors
beta oxidation
peroxisome proliferator-activated receptors
Liver
genetic background
homeostasis
Homeostasis
Fatty Acids
Diet
fatty acids
Lipids

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Kim, Bang Hyun ; Won, Young Suk ; Kim, Eun Young ; Yoon, Mijung ; Nam, KiTaek ; Oh, Goo Taeg ; Kim, Dae Yong. / Phenotype of peroxisome proliferator-activated receptor-alpha(PPARalpha)deficient mice on mixed background fed high fat diet. In: Journal of veterinary science (Suwon-si, Korea). 2003 ; Vol. 4, No. 3. pp. 239-244.
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Phenotype of peroxisome proliferator-activated receptor-alpha(PPARalpha)deficient mice on mixed background fed high fat diet. / Kim, Bang Hyun; Won, Young Suk; Kim, Eun Young; Yoon, Mijung; Nam, KiTaek; Oh, Goo Taeg; Kim, Dae Yong.

In: Journal of veterinary science (Suwon-si, Korea), Vol. 4, No. 3, 01.01.2003, p. 239-244.

Research output: Contribution to journalArticle

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