TY - JOUR
T1 - Phospholipase D meets Wnt signaling
T2 - A new target for cancer therapy
AU - Kang, Dong Woo
AU - Choi, Kang Yell
AU - Min, Do Sik
PY - 2011/1/15
Y1 - 2011/1/15
N2 - Phospholipase D (PLD) has been increasingly recognized as a critical regulator of cell proliferation and tumorigenesis. PLD regulates downstream effectors by generating phosphatidic acid (PA), and the expression and activity of PLD are elevated in many different types of human cancer. Aberrant activation of Wnt/b-catenin signaling, followed by hyper-activation of target genes, is linked to a wide range of cancers. New studies reveal a direct connection between the PLD and the Wnt signaling pathways; PLD is a transcriptional target of β-catenin/ T-cell factor (TCF) and reinforces Wnt/β-catenin signaling related with cellular transformation. In this review, we discuss the emerging importance of PLD and PA in the Wnt/β-catenin signaling network, which is associated with tumorigenesis, and suggest that the PLD/PA signaling pathway is a potential therapeutic target for the treatment of cancer.
AB - Phospholipase D (PLD) has been increasingly recognized as a critical regulator of cell proliferation and tumorigenesis. PLD regulates downstream effectors by generating phosphatidic acid (PA), and the expression and activity of PLD are elevated in many different types of human cancer. Aberrant activation of Wnt/b-catenin signaling, followed by hyper-activation of target genes, is linked to a wide range of cancers. New studies reveal a direct connection between the PLD and the Wnt signaling pathways; PLD is a transcriptional target of β-catenin/ T-cell factor (TCF) and reinforces Wnt/β-catenin signaling related with cellular transformation. In this review, we discuss the emerging importance of PLD and PA in the Wnt/β-catenin signaling network, which is associated with tumorigenesis, and suggest that the PLD/PA signaling pathway is a potential therapeutic target for the treatment of cancer.
UR - http://www.scopus.com/inward/record.url?scp=78751480479&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78751480479&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-10-2463
DO - 10.1158/0008-5472.CAN-10-2463
M3 - Review article
C2 - 21224347
AN - SCOPUS:78751480479
SN - 0008-5472
VL - 71
SP - 293
EP - 297
JO - Cancer Research
JF - Cancer Research
IS - 2
ER -
