Phosphorescence bioimaging using cyclometalated Ir(III) complexes

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Recent advances in the development of the phosphorescent Ir(III) complexes have made it possible to implement the phosphorescence modality in bioimaging applications. A variety of phosphorescent Ir(III) complexes have been synthesized and assessed in the context of in vitro and in vivo imaging, especially in subcellular organelle staining and the sensing of biologically important analytes. The examples presented here demonstrate that Ir(III) complexes provide attractive alternatives to fluorescent organic compounds in the construction of biolabels and biosensors. The complexes are particularly advantageous with respect to fluorescent compounds in their compatibility with time-gated bioimaging techniques that completely eliminate background signals due to autofluorescence.

Original languageEnglish
Pages (from-to)699-707
Number of pages9
JournalCurrent Opinion in Chemical Biology
Issue number4
Publication statusPublished - 2013 Aug

Bibliographical note

Funding Information:
The author appreciates the financial support of the Kyung Hee University .

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry


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