TY - JOUR
T1 - Photoacoustic imaging of breast microcalcifications
T2 - A validation study with 3-dimensional ex vivo data and spectrophotometric measurement
AU - Kang, Jeeun
AU - Kim, Eun Kyung
AU - Kim, Ga Ram
AU - Yoon, Changhan
AU - Song, Tai Kyong
AU - Chang, Jin Ho
N1 - Publisher Copyright:
© 2013 WILEY-VCH Verlag GmbH &Co. KGaA, Weinheim).
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - This paper investigates whether photoacoustic imaging (PAI) can provide the visualization of microcalcifications in breast tissue. For this, the geometrical correlation between the 3-D PA images of breast microcalcifications within ex vivo specimens and the corresponding mammograms was ascertained. Also, the optical absorbance of the calcification compositions (i.e., hydroxyapatite and calcium oxalate) was measured and compared with the PA responses of the microcalcifications. The experimental results demonstrated that the PA images discriminated between the microcalcifications and the surrounding tissue, and their locations in PA images reasonably meshed with those of the microcalcifications appeared in the mammograms. Also, the change in PA signal amplitude along the laser wavelength agreed with the absorbance of hydroxyapatite associated with the relatively high potential of malignant cancers, but not calcium oxalate with only benign cases. (
AB - This paper investigates whether photoacoustic imaging (PAI) can provide the visualization of microcalcifications in breast tissue. For this, the geometrical correlation between the 3-D PA images of breast microcalcifications within ex vivo specimens and the corresponding mammograms was ascertained. Also, the optical absorbance of the calcification compositions (i.e., hydroxyapatite and calcium oxalate) was measured and compared with the PA responses of the microcalcifications. The experimental results demonstrated that the PA images discriminated between the microcalcifications and the surrounding tissue, and their locations in PA images reasonably meshed with those of the microcalcifications appeared in the mammograms. Also, the change in PA signal amplitude along the laser wavelength agreed with the absorbance of hydroxyapatite associated with the relatively high potential of malignant cancers, but not calcium oxalate with only benign cases. (
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U2 - 10.1002/jbio.201300100
DO - 10.1002/jbio.201300100
M3 - Article
C2 - 23996971
AN - SCOPUS:84921051059
VL - 8
SP - 71
EP - 80
JO - Journal of Biophotonics
JF - Journal of Biophotonics
SN - 1864-063X
IS - 1-2
ER -