Abstract
This paper investigates whether photoacoustic imaging (PAI) can provide the visualization of microcalcifications in breast tissue. For this, the geometrical correlation between the 3-D PA images of breast microcalcifications within ex vivo specimens and the corresponding mammograms was ascertained. Also, the optical absorbance of the calcification compositions (i.e., hydroxyapatite and calcium oxalate) was measured and compared with the PA responses of the microcalcifications. The experimental results demonstrated that the PA images discriminated between the microcalcifications and the surrounding tissue, and their locations in PA images reasonably meshed with those of the microcalcifications appeared in the mammograms. Also, the change in PA signal amplitude along the laser wavelength agreed with the absorbance of hydroxyapatite associated with the relatively high potential of malignant cancers, but not calcium oxalate with only benign cases. (
| Original language | English |
|---|---|
| Pages (from-to) | 71-80 |
| Number of pages | 10 |
| Journal | Journal of Biophotonics |
| Volume | 8 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Materials Science(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Engineering(all)
- Physics and Astronomy(all)
Cite this
}
Photoacoustic imaging of breast microcalcifications : A validation study with 3-dimensional ex vivo data and spectrophotometric measurement. / Kang, Jeeun; Kim, Eunkyung; Kim, Ga Ram; Yoon, Changhan; Song, Tai Kyong; Chang, Jin Ho.
In: Journal of Biophotonics, Vol. 8, No. 1-2, 01.01.2015, p. 71-80.Research output: Contribution to journal › Article
TY - JOUR
T1 - Photoacoustic imaging of breast microcalcifications
T2 - A validation study with 3-dimensional ex vivo data and spectrophotometric measurement
AU - Kang, Jeeun
AU - Kim, Eunkyung
AU - Kim, Ga Ram
AU - Yoon, Changhan
AU - Song, Tai Kyong
AU - Chang, Jin Ho
PY - 2015/1/1
Y1 - 2015/1/1
N2 - This paper investigates whether photoacoustic imaging (PAI) can provide the visualization of microcalcifications in breast tissue. For this, the geometrical correlation between the 3-D PA images of breast microcalcifications within ex vivo specimens and the corresponding mammograms was ascertained. Also, the optical absorbance of the calcification compositions (i.e., hydroxyapatite and calcium oxalate) was measured and compared with the PA responses of the microcalcifications. The experimental results demonstrated that the PA images discriminated between the microcalcifications and the surrounding tissue, and their locations in PA images reasonably meshed with those of the microcalcifications appeared in the mammograms. Also, the change in PA signal amplitude along the laser wavelength agreed with the absorbance of hydroxyapatite associated with the relatively high potential of malignant cancers, but not calcium oxalate with only benign cases. (
AB - This paper investigates whether photoacoustic imaging (PAI) can provide the visualization of microcalcifications in breast tissue. For this, the geometrical correlation between the 3-D PA images of breast microcalcifications within ex vivo specimens and the corresponding mammograms was ascertained. Also, the optical absorbance of the calcification compositions (i.e., hydroxyapatite and calcium oxalate) was measured and compared with the PA responses of the microcalcifications. The experimental results demonstrated that the PA images discriminated between the microcalcifications and the surrounding tissue, and their locations in PA images reasonably meshed with those of the microcalcifications appeared in the mammograms. Also, the change in PA signal amplitude along the laser wavelength agreed with the absorbance of hydroxyapatite associated with the relatively high potential of malignant cancers, but not calcium oxalate with only benign cases. (
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U2 - 10.1002/jbio.201300100
DO - 10.1002/jbio.201300100
M3 - Article
VL - 8
SP - 71
EP - 80
JO - Journal of Biophotonics
JF - Journal of Biophotonics
SN - 1864-063X
IS - 1-2
ER -