Photoacoustic imaging of breast microcalcifications

A validation study with 3-dimensional ex vivo data and spectrophotometric measurement

Jeeun Kang, Eunkyung Kim, Ga Ram Kim, Changhan Yoon, Tai Kyong Song, Jin Ho Chang

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

This paper investigates whether photoacoustic imaging (PAI) can provide the visualization of microcalcifications in breast tissue. For this, the geometrical correlation between the 3-D PA images of breast microcalcifications within ex vivo specimens and the corresponding mammograms was ascertained. Also, the optical absorbance of the calcification compositions (i.e., hydroxyapatite and calcium oxalate) was measured and compared with the PA responses of the microcalcifications. The experimental results demonstrated that the PA images discriminated between the microcalcifications and the surrounding tissue, and their locations in PA images reasonably meshed with those of the microcalcifications appeared in the mammograms. Also, the change in PA signal amplitude along the laser wavelength agreed with the absorbance of hydroxyapatite associated with the relatively high potential of malignant cancers, but not calcium oxalate with only benign cases. (

Original languageEnglish
Pages (from-to)71-80
Number of pages10
JournalJournal of Biophotonics
Volume8
Issue number1-2
DOIs
Publication statusPublished - 2015 Jan 1

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Calcinosis
Calcium Oxalate
Photoacoustic effect
Validation Studies
Hydroxyapatite
breast
Calcium
Calcification (biochemistry)
Breast
oxalates
Tissue
Imaging techniques
calcium
Durapatite
calcification
Visualization
Wavelength
Lasers
cancer
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Kang, Jeeun ; Kim, Eunkyung ; Kim, Ga Ram ; Yoon, Changhan ; Song, Tai Kyong ; Chang, Jin Ho. / Photoacoustic imaging of breast microcalcifications : A validation study with 3-dimensional ex vivo data and spectrophotometric measurement. In: Journal of Biophotonics. 2015 ; Vol. 8, No. 1-2. pp. 71-80.
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Photoacoustic imaging of breast microcalcifications : A validation study with 3-dimensional ex vivo data and spectrophotometric measurement. / Kang, Jeeun; Kim, Eunkyung; Kim, Ga Ram; Yoon, Changhan; Song, Tai Kyong; Chang, Jin Ho.

In: Journal of Biophotonics, Vol. 8, No. 1-2, 01.01.2015, p. 71-80.

Research output: Contribution to journalArticle

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