Photoacoustic imaging of breast microcalcifications

A validation study with 3-dimensional ex vivo data

Jeeun Kang, Eunkyung Kim, Tai Kyong Song, Jin Ho Chang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Breast microcalcification has been served as an important early-indicator of breast cancer. In the conventional screening procedure for the breast cancer, X-ray mammography is first conducted and the malignancy of the suspicious patient is confirmed by conducting needle biopsy with real-time imaging-assisted guidance, i.e., stereotactic and US imaging. However, these biopsy guidance methods suffer from large amount of radiative exposure and limited sensitivity on microcalcifications without a mass, respectively. In this paper, we verify the capability of photoacoustic imaging (PAI) for detection of the breast microcalcifications by comparing their locations in a 3-D PA image with those in the corresponding X-ray mammography. For this, cross-sectional PA/US images of breast ex vivo specimens were sequentially acquired with 7.2-MHz linear array transducer and the procedure was repeated by moving the transducer along the elevation direction at an increment of 0.3 mm. A Surelite Nd:YAG OPO system (Continuum Inc., USA) was used for the laser excitation at the rate of 10 Hz with a bifurcated optical fiber bundle for laser delivery. PA signals generated in the specimen were captured with SonixTouch research package (Ultrasonix Corp., Canada). With a volume-rendered PA/US image, it is shown that the locations of the microcalcifications in the X-ray mammography meshed well with those in PA images. From the experimental results, therefore, it is demonstrates that PAI can be an effective alternative for noninvasive, real-time biopsy guidance for breast cancer screening.

Original languageEnglish
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages28-31
Number of pages4
DOIs
Publication statusPublished - 2012 Dec 1
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: 2012 Oct 72012 Oct 10

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period12/10/712/10/10

Fingerprint

breast
cancer
transducers
screening
x rays
linear arrays
Canada
needles
yttrium-aluminum garnet
bundles
lasers
delivery
optical fibers
continuums
conduction
sensitivity
excitation

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

Cite this

Kang, J., Kim, E., Song, T. K., & Chang, J. H. (2012). Photoacoustic imaging of breast microcalcifications: A validation study with 3-dimensional ex vivo data. In 2012 IEEE International Ultrasonics Symposium, IUS 2012 (pp. 28-31). [6562023] https://doi.org/10.1109/ULTSYM.2012.0008
Kang, Jeeun ; Kim, Eunkyung ; Song, Tai Kyong ; Chang, Jin Ho. / Photoacoustic imaging of breast microcalcifications : A validation study with 3-dimensional ex vivo data. 2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. pp. 28-31
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abstract = "Breast microcalcification has been served as an important early-indicator of breast cancer. In the conventional screening procedure for the breast cancer, X-ray mammography is first conducted and the malignancy of the suspicious patient is confirmed by conducting needle biopsy with real-time imaging-assisted guidance, i.e., stereotactic and US imaging. However, these biopsy guidance methods suffer from large amount of radiative exposure and limited sensitivity on microcalcifications without a mass, respectively. In this paper, we verify the capability of photoacoustic imaging (PAI) for detection of the breast microcalcifications by comparing their locations in a 3-D PA image with those in the corresponding X-ray mammography. For this, cross-sectional PA/US images of breast ex vivo specimens were sequentially acquired with 7.2-MHz linear array transducer and the procedure was repeated by moving the transducer along the elevation direction at an increment of 0.3 mm. A Surelite Nd:YAG OPO system (Continuum Inc., USA) was used for the laser excitation at the rate of 10 Hz with a bifurcated optical fiber bundle for laser delivery. PA signals generated in the specimen were captured with SonixTouch research package (Ultrasonix Corp., Canada). With a volume-rendered PA/US image, it is shown that the locations of the microcalcifications in the X-ray mammography meshed well with those in PA images. From the experimental results, therefore, it is demonstrates that PAI can be an effective alternative for noninvasive, real-time biopsy guidance for breast cancer screening.",
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Kang, J, Kim, E, Song, TK & Chang, JH 2012, Photoacoustic imaging of breast microcalcifications: A validation study with 3-dimensional ex vivo data. in 2012 IEEE International Ultrasonics Symposium, IUS 2012., 6562023, pp. 28-31, 2012 IEEE International Ultrasonics Symposium, IUS 2012, Dresden, Germany, 12/10/7. https://doi.org/10.1109/ULTSYM.2012.0008

Photoacoustic imaging of breast microcalcifications : A validation study with 3-dimensional ex vivo data. / Kang, Jeeun; Kim, Eunkyung; Song, Tai Kyong; Chang, Jin Ho.

2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. p. 28-31 6562023.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Kang J, Kim E, Song TK, Chang JH. Photoacoustic imaging of breast microcalcifications: A validation study with 3-dimensional ex vivo data. In 2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. p. 28-31. 6562023 https://doi.org/10.1109/ULTSYM.2012.0008