Photoacoustic imaging of breast microcalcifications: A validation study with 3-dimensional ex vivo data

Jeeun Kang, Eun Kyung Kim, Tai Kyong Song, Jin Ho Chang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Breast microcalcification has been served as an important early-indicator of breast cancer. In the conventional screening procedure for the breast cancer, X-ray mammography is first conducted and the malignancy of the suspicious patient is confirmed by conducting needle biopsy with real-time imaging-assisted guidance, i.e., stereotactic and US imaging. However, these biopsy guidance methods suffer from large amount of radiative exposure and limited sensitivity on microcalcifications without a mass, respectively. In this paper, we verify the capability of photoacoustic imaging (PAI) for detection of the breast microcalcifications by comparing their locations in a 3-D PA image with those in the corresponding X-ray mammography. For this, cross-sectional PA/US images of breast ex vivo specimens were sequentially acquired with 7.2-MHz linear array transducer and the procedure was repeated by moving the transducer along the elevation direction at an increment of 0.3 mm. A Surelite Nd:YAG OPO system (Continuum Inc., USA) was used for the laser excitation at the rate of 10 Hz with a bifurcated optical fiber bundle for laser delivery. PA signals generated in the specimen were captured with SonixTouch research package (Ultrasonix Corp., Canada). With a volume-rendered PA/US image, it is shown that the locations of the microcalcifications in the X-ray mammography meshed well with those in PA images. From the experimental results, therefore, it is demonstrates that PAI can be an effective alternative for noninvasive, real-time biopsy guidance for breast cancer screening.

Original languageEnglish
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages28-31
Number of pages4
DOIs
Publication statusPublished - 2012 Dec 1
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: 2012 Oct 72012 Oct 10

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period12/10/712/10/10

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

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    Kang, J., Kim, E. K., Song, T. K., & Chang, J. H. (2012). Photoacoustic imaging of breast microcalcifications: A validation study with 3-dimensional ex vivo data. In 2012 IEEE International Ultrasonics Symposium, IUS 2012 (pp. 28-31). [6562023] (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2012.0008