Abstract
Breast microcalcification has been served as an important early-indicator of breast cancer. In the conventional screening procedure for the breast cancer, X-ray mammography is first conducted and the malignancy of the suspicious patient is confirmed by conducting needle biopsy with real-time imaging-assisted guidance, i.e., stereotactic and US imaging. However, these biopsy guidance methods suffer from large amount of radiative exposure and limited sensitivity on microcalcifications without a mass, respectively. In this paper, we verify the capability of photoacoustic imaging (PAI) for detection of the breast microcalcifications by comparing their locations in a 3-D PA image with those in the corresponding X-ray mammography. For this, cross-sectional PA/US images of breast ex vivo specimens were sequentially acquired with 7.2-MHz linear array transducer and the procedure was repeated by moving the transducer along the elevation direction at an increment of 0.3 mm. A Surelite Nd:YAG OPO system (Continuum Inc., USA) was used for the laser excitation at the rate of 10 Hz with a bifurcated optical fiber bundle for laser delivery. PA signals generated in the specimen were captured with SonixTouch research package (Ultrasonix Corp., Canada). With a volume-rendered PA/US image, it is shown that the locations of the microcalcifications in the X-ray mammography meshed well with those in PA images. From the experimental results, therefore, it is demonstrates that PAI can be an effective alternative for noninvasive, real-time biopsy guidance for breast cancer screening.
| Original language | English |
|---|---|
| Title of host publication | 2012 IEEE International Ultrasonics Symposium, IUS 2012 |
| Pages | 28-31 |
| Number of pages | 4 |
| DOIs | |
| Publication status | Published - 2012 Dec 1 |
| Event | 2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany Duration: 2012 Oct 7 → 2012 Oct 10 |
Other
| Other | 2012 IEEE International Ultrasonics Symposium, IUS 2012 |
|---|---|
| Country | Germany |
| City | Dresden |
| Period | 12/10/7 → 12/10/10 |
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All Science Journal Classification (ASJC) codes
- Acoustics and Ultrasonics
Cite this
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Photoacoustic imaging of breast microcalcifications : A validation study with 3-dimensional ex vivo data. / Kang, Jeeun; Kim, Eunkyung; Song, Tai Kyong; Chang, Jin Ho.
2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. p. 28-31 6562023.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Photoacoustic imaging of breast microcalcifications
T2 - A validation study with 3-dimensional ex vivo data
AU - Kang, Jeeun
AU - Kim, Eunkyung
AU - Song, Tai Kyong
AU - Chang, Jin Ho
PY - 2012/12/1
Y1 - 2012/12/1
N2 - Breast microcalcification has been served as an important early-indicator of breast cancer. In the conventional screening procedure for the breast cancer, X-ray mammography is first conducted and the malignancy of the suspicious patient is confirmed by conducting needle biopsy with real-time imaging-assisted guidance, i.e., stereotactic and US imaging. However, these biopsy guidance methods suffer from large amount of radiative exposure and limited sensitivity on microcalcifications without a mass, respectively. In this paper, we verify the capability of photoacoustic imaging (PAI) for detection of the breast microcalcifications by comparing their locations in a 3-D PA image with those in the corresponding X-ray mammography. For this, cross-sectional PA/US images of breast ex vivo specimens were sequentially acquired with 7.2-MHz linear array transducer and the procedure was repeated by moving the transducer along the elevation direction at an increment of 0.3 mm. A Surelite Nd:YAG OPO system (Continuum Inc., USA) was used for the laser excitation at the rate of 10 Hz with a bifurcated optical fiber bundle for laser delivery. PA signals generated in the specimen were captured with SonixTouch research package (Ultrasonix Corp., Canada). With a volume-rendered PA/US image, it is shown that the locations of the microcalcifications in the X-ray mammography meshed well with those in PA images. From the experimental results, therefore, it is demonstrates that PAI can be an effective alternative for noninvasive, real-time biopsy guidance for breast cancer screening.
AB - Breast microcalcification has been served as an important early-indicator of breast cancer. In the conventional screening procedure for the breast cancer, X-ray mammography is first conducted and the malignancy of the suspicious patient is confirmed by conducting needle biopsy with real-time imaging-assisted guidance, i.e., stereotactic and US imaging. However, these biopsy guidance methods suffer from large amount of radiative exposure and limited sensitivity on microcalcifications without a mass, respectively. In this paper, we verify the capability of photoacoustic imaging (PAI) for detection of the breast microcalcifications by comparing their locations in a 3-D PA image with those in the corresponding X-ray mammography. For this, cross-sectional PA/US images of breast ex vivo specimens were sequentially acquired with 7.2-MHz linear array transducer and the procedure was repeated by moving the transducer along the elevation direction at an increment of 0.3 mm. A Surelite Nd:YAG OPO system (Continuum Inc., USA) was used for the laser excitation at the rate of 10 Hz with a bifurcated optical fiber bundle for laser delivery. PA signals generated in the specimen were captured with SonixTouch research package (Ultrasonix Corp., Canada). With a volume-rendered PA/US image, it is shown that the locations of the microcalcifications in the X-ray mammography meshed well with those in PA images. From the experimental results, therefore, it is demonstrates that PAI can be an effective alternative for noninvasive, real-time biopsy guidance for breast cancer screening.
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U2 - 10.1109/ULTSYM.2012.0008
DO - 10.1109/ULTSYM.2012.0008
M3 - Conference contribution
SN - 9781467345613
SP - 28
EP - 31
BT - 2012 IEEE International Ultrasonics Symposium, IUS 2012
ER -