Photodynamic therapy and gene therapy using dendrimer

Woo Dong Jang, Nobuhiro Nishiyama, Kazunori Kataoka

Research output: Contribution to conferencePaper

Abstract

Recently, we have reported ionic dendrimer porphyrin as an efficient photosensitizer for photodynamic therapy. In present work, novel poly(benzyl ether) dendrimer, which have phthalocyanine as a core unit, were synthesized as potential candidates of photosensitizer. The dendrimer exhibited large absorption bands at quite longer wavelength region than that of previously reported dendrimer porphyrin, and formed uniform micelle when the dendrimers mixed with same charge ratio of PEG-PLL block copolymer in 10 mM of PBS. On the other hand, we newly designed ternary complex of dendrimer phthalocyanine with plasmid DNA and cationic polymers to evaluate its DNA transfection efficacy. The result of in vitro and in vivo evaluation of PDT effect and DNA transfection efficacy of polyion complex micelle and ternary complex, respectively, will be described.

Original languageEnglish
Pages2825-2826
Number of pages2
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 2005 Sep 202005 Sep 22

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period05/9/2005/9/22

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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    Jang, W. D., Nishiyama, N., & Kataoka, K. (2005). Photodynamic therapy and gene therapy using dendrimer. 2825-2826. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.