Photorefractive keratectomy combined with corneal wavefront–guided and hyperaspheric ablation profiles to correct myopia

Purpose To evaluate the effects of photorefractive keratectomy (PRK) combined with corneal wavefront–guided ablation profiles and hyperaspheric ablation profiles on changes in higher-order aberrations (HOAs). Setting Yonsei University College of Medicine and Eyereum Clinic, Seoul, South Korea. Design Comparative observational case series. Methods Medical records of patients who had corneal wavefront–guided hyperaspheric PRK, corneal wavefront–guided mild-aspheric PRK, or non-corneal wavefront–guided mild-aspheric PRK were analyzed. The logMAR uncorrected distance visual acuity (UDVA), manifest refraction spherical equivalent (MRSE), and changes in corneal aberrations (root-mean-square [RMS] HOAs, spherical aberration, coma) were evaluated 1, 3, and 6 months postoperatively. Results The records of 61 patients (96 eyes) were reviewed. There was no statistically significant difference in logMAR UDVA or MRSE between the 3 groups at any timepoint. Corneal RMS HOAs were significantly smaller in the corneal wavefront–guided hyperaspheric group and the corneal wavefront–guided mild-aspheric group than in the noncorneal wavefront–guided mild-aspheric group at each timepoint. Corneal spherical aberration was significantly smaller for corneal wavefront–guided hyperaspheric PRK than for noncorneal wavefront–guided mild-aspheric PRK 6 months postoperatively. Changes in corneal spherical aberration (preoperatively and 6 months postoperatively) in corneal wavefront–guided hyperaspheric PRK were significantly smaller than in corneal wavefront–guided mild-aspheric PRK (P =.046). Corneal coma was significantly smaller with corneal wavefront–guided hyperaspheric PRK and corneal wavefront–guided mild-aspheric PRK than with noncorneal wavefront–guided mild-aspheric PRK 3 months and 6 months postoperatively. Conclusion Corneal wavefront–guided hyperaspheric PRK induced less corneal spherical aberration 6 months postoperatively than corneal wavefront–guided mild-aspheric PRK and noncorneal wavefront–guided mild-aspheric PRK. Financial Disclosure None of the authors has a financial or proprietary interest in any material or method mentioned.