Photothermally induced local dissociation of collagens for harvesting of cell sheets

Jae Dong Kim, June Seok Heo, Teahoon Park, Chihyun Park, Hyun Ok Kim, Eunkyoung Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The local heating of poly(3,4-ethylenedioxythiophene) (PEDOT) by a photothermal effect directed by near-infrared (NIR) light induces unfolding of absorbed collagen triple helices, yielding soluble collagen single-helical structures. This dissociation of collagens allowed the harvesting of a living idiomorphic cell sheet, achieved upon irradiation with NIR light (λ=808 nm). The PEDOT layer was patterned and cells were successfully cultured on the patterned substrate. Cell sheets of various shapes mirroring the PEDOT pattern could be detached after a few minutes of irradiation with NIR light. The PEDOT patterns guided not only the entire shape of the cell sheets but also the spreading direction of the cells in the sheets. This photothermally induced dissociation of collagen provided a fast non-invasive harvesting method and tailor-made cell-sheet patterns.

Original languageEnglish
Pages (from-to)5869-5873
Number of pages5
JournalAngewandte Chemie - International Edition
Volume54
Issue number20
DOIs
Publication statusPublished - 2015 May 11

Fingerprint

Collagen
Infrared radiation
Irradiation
Heating
poly(3,4-ethylene dioxythiophene)
Substrates

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Kim, Jae Dong ; Heo, June Seok ; Park, Teahoon ; Park, Chihyun ; Kim, Hyun Ok ; Kim, Eunkyoung. / Photothermally induced local dissociation of collagens for harvesting of cell sheets. In: Angewandte Chemie - International Edition. 2015 ; Vol. 54, No. 20. pp. 5869-5873.
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Photothermally induced local dissociation of collagens for harvesting of cell sheets. / Kim, Jae Dong; Heo, June Seok; Park, Teahoon; Park, Chihyun; Kim, Hyun Ok; Kim, Eunkyoung.

In: Angewandte Chemie - International Edition, Vol. 54, No. 20, 11.05.2015, p. 5869-5873.

Research output: Contribution to journalArticle

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