Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses’ Health Study II

Leandro Fórnias Machado de Rezende; Dong Hoon Lee; Na Na Keum; Katharina Nimptsch; Mingyang Song; I. Min Lee; José Eluf-Neto; Shuji Ogino; Charles Fuchs; Jeffrey Meyerhardt; Andrew T. Chan; Walter Willett; Edward Giovannucci; Kana Wu

doi:10.1038/s41416-019-0454-1

Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses’ Health Study II

Leandro Fórnias Machado de Rezende, Dong Hoon Lee, Na Na Keum, Katharina Nimptsch, Mingyang Song, I. Min Lee, José Eluf-Neto, Shuji Ogino, Charles Fuchs, Jeffrey Meyerhardt, Andrew T. Chan, Walter Willett, Edward Giovannucci, Kana Wu

Department of Sports Industry Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Physical activity during adulthood has been consistently associated with lower risk of colorectal cancers, but whether physical activity during adolescence may also play a role in colorectal carcinogenesis is unclear. Methods: We included 28,250 women in the Nurses’ Health Study II who provided data on physical activity during adolescence (ages 12–22 years) in 1997 and underwent lower bowel endoscopy (1998–2011). We used logistic regression models for clustered data to examine the association between physical activity during adolescence and risk of adenoma later in life. Results: Physical activity during adolescence was inversely associated with risk of colorectal adenoma (2373 cases), independent of physical activity during adulthood. The multivariable-adjusted odds ratio (OR) of adenoma was 0.89 (95% CI 0.77–1.02; P_trend = 0.03) comparing women with ≥ 72 metabolic equivalent of tasks-hours/week (MET-h/week) to < 21 MET-h/week. Women with high physical activity during both adolescence (≥53.3 MET-h/week) and adulthood (≥23.1 MET-h/week) had significantly lower risk of adenoma (all adenomas: OR 0.76; 95% CI 0.66–0.88; advanced adenoma: OR 0.61; 95% CI 0.45–0.82) compared to women with low physical activity during both stages of life. Conclusions: Our findings suggest that physical activity during adolescence may lower the risk of colorectal adenoma later in life.

Original language	English
Pages (from-to)	86-94
Number of pages	9
Journal	British journal of cancer
Volume	121
Issue number	1
DOIs	https://doi.org/10.1038/s41416-019-0454-1
Publication status	Published - 2019 Jul 2

Bibliographical note

Funding Information:
Funding: The Nurses’ Health Study II was funded by the National Cancer Institute (NCI), National Institutes of Health (UM1 CA176726 to WW). Leandro Fórnias Machado de Rezende receives a doctoral fellowship from the Coordination for the Improvement of Higher Education Personnel (CAPES) and the Sao Paulo Research Foundation (FAPESP), grant #2016/21390–0 and #2014/25614-4. NCI grants R03 CA197879 to KW, R21 CA222940 to K.W. and Reiko Nishihara, R21 CA230873 to K.W. and S.O., R35 CA197735 to S.O., P50 CA127003 to C.S.F. The American Cancer Society (grant number MRSG-17-220-01 – NEC to M.S.). The National Institutes of Health grants K99 CA215314 and R00 CA215314 to M.S. N.K. was supported by grants from the National Research Foundation of Korea (NRF-2018R1C1B6008822; NRF-2018R1A4A1022589); the Dongguk University Research Grant of 2017. This work was also in part supported by an Investigator Initiated Grant from the American Institute for Cancer Research (AICR) to KW.

Publisher Copyright:
© 2019, Cancer Research UK.

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41416-019-0454-1

Cite this

Rezende, L. F. M. D., Lee, D. H., Keum, N. N., Nimptsch, K., Song, M., Lee, I. M., Eluf-Neto, J., Ogino, S., Fuchs, C., Meyerhardt, J., Chan, A. T., Willett, W., Giovannucci, E., & Wu, K. (2019). Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses’ Health Study II. British journal of cancer, 121(1), 86-94. https://doi.org/10.1038/s41416-019-0454-1

@article{892a4f34e10a43698fb47531b55e5fcd,

title = "Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses{\textquoteright} Health Study II",

abstract = "Background: Physical activity during adulthood has been consistently associated with lower risk of colorectal cancers, but whether physical activity during adolescence may also play a role in colorectal carcinogenesis is unclear. Methods: We included 28,250 women in the Nurses{\textquoteright} Health Study II who provided data on physical activity during adolescence (ages 12–22 years) in 1997 and underwent lower bowel endoscopy (1998–2011). We used logistic regression models for clustered data to examine the association between physical activity during adolescence and risk of adenoma later in life. Results: Physical activity during adolescence was inversely associated with risk of colorectal adenoma (2373 cases), independent of physical activity during adulthood. The multivariable-adjusted odds ratio (OR) of adenoma was 0.89 (95% CI 0.77–1.02; Ptrend = 0.03) comparing women with ≥ 72 metabolic equivalent of tasks-hours/week (MET-h/week) to < 21 MET-h/week. Women with high physical activity during both adolescence (≥53.3 MET-h/week) and adulthood (≥23.1 MET-h/week) had significantly lower risk of adenoma (all adenomas: OR 0.76; 95% CI 0.66–0.88; advanced adenoma: OR 0.61; 95% CI 0.45–0.82) compared to women with low physical activity during both stages of life. Conclusions: Our findings suggest that physical activity during adolescence may lower the risk of colorectal adenoma later in life.",

author = "Rezende, {Leandro F{\'o}rnias Machado de} and Lee, {Dong Hoon} and Keum, {Na Na} and Katharina Nimptsch and Mingyang Song and Lee, {I. Min} and Jos{\'e} Eluf-Neto and Shuji Ogino and Charles Fuchs and Jeffrey Meyerhardt and Chan, {Andrew T.} and Walter Willett and Edward Giovannucci and Kana Wu",

note = "Funding Information: Funding: The Nurses{\textquoteright} Health Study II was funded by the National Cancer Institute (NCI), National Institutes of Health (UM1 CA176726 to WW). Leandro F{\'o}rnias Machado de Rezende receives a doctoral fellowship from the Coordination for the Improvement of Higher Education Personnel (CAPES) and the Sao Paulo Research Foundation (FAPESP), grant #2016/21390–0 and #2014/25614-4. NCI grants R03 CA197879 to KW, R21 CA222940 to K.W. and Reiko Nishihara, R21 CA230873 to K.W. and S.O., R35 CA197735 to S.O., P50 CA127003 to C.S.F. The American Cancer Society (grant number MRSG-17-220-01 – NEC to M.S.). The National Institutes of Health grants K99 CA215314 and R00 CA215314 to M.S. N.K. was supported by grants from the National Research Foundation of Korea (NRF-2018R1C1B6008822; NRF-2018R1A4A1022589); the Dongguk University Research Grant of 2017. This work was also in part supported by an Investigator Initiated Grant from the American Institute for Cancer Research (AICR) to KW. Publisher Copyright: {\textcopyright} 2019, Cancer Research UK.",

year = "2019",

month = jul,

day = "2",

doi = "10.1038/s41416-019-0454-1",

language = "English",

volume = "121",

pages = "86--94",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

number = "1",

}

Rezende, LFMD, Lee, DH, Keum, NN, Nimptsch, K, Song, M, Lee, IM, Eluf-Neto, J, Ogino, S, Fuchs, C, Meyerhardt, J, Chan, AT, Willett, W, Giovannucci, E & Wu, K 2019, 'Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses’ Health Study II', British journal of cancer, vol. 121, no. 1, pp. 86-94. https://doi.org/10.1038/s41416-019-0454-1

TY - JOUR

T1 - Physical activity during adolescence and risk of colorectal adenoma later in life

T2 - results from the Nurses’ Health Study II

AU - Rezende, Leandro Fórnias Machado de

AU - Lee, Dong Hoon

AU - Keum, Na Na

AU - Nimptsch, Katharina

AU - Song, Mingyang

AU - Lee, I. Min

AU - Eluf-Neto, José

AU - Ogino, Shuji

AU - Fuchs, Charles

AU - Meyerhardt, Jeffrey

AU - Chan, Andrew T.

AU - Willett, Walter

AU - Giovannucci, Edward

AU - Wu, Kana

N1 - Funding Information: Funding: The Nurses’ Health Study II was funded by the National Cancer Institute (NCI), National Institutes of Health (UM1 CA176726 to WW). Leandro Fórnias Machado de Rezende receives a doctoral fellowship from the Coordination for the Improvement of Higher Education Personnel (CAPES) and the Sao Paulo Research Foundation (FAPESP), grant #2016/21390–0 and #2014/25614-4. NCI grants R03 CA197879 to KW, R21 CA222940 to K.W. and Reiko Nishihara, R21 CA230873 to K.W. and S.O., R35 CA197735 to S.O., P50 CA127003 to C.S.F. The American Cancer Society (grant number MRSG-17-220-01 – NEC to M.S.). The National Institutes of Health grants K99 CA215314 and R00 CA215314 to M.S. N.K. was supported by grants from the National Research Foundation of Korea (NRF-2018R1C1B6008822; NRF-2018R1A4A1022589); the Dongguk University Research Grant of 2017. This work was also in part supported by an Investigator Initiated Grant from the American Institute for Cancer Research (AICR) to KW. Publisher Copyright: © 2019, Cancer Research UK.

PY - 2019/7/2

Y1 - 2019/7/2

N2 - Background: Physical activity during adulthood has been consistently associated with lower risk of colorectal cancers, but whether physical activity during adolescence may also play a role in colorectal carcinogenesis is unclear. Methods: We included 28,250 women in the Nurses’ Health Study II who provided data on physical activity during adolescence (ages 12–22 years) in 1997 and underwent lower bowel endoscopy (1998–2011). We used logistic regression models for clustered data to examine the association between physical activity during adolescence and risk of adenoma later in life. Results: Physical activity during adolescence was inversely associated with risk of colorectal adenoma (2373 cases), independent of physical activity during adulthood. The multivariable-adjusted odds ratio (OR) of adenoma was 0.89 (95% CI 0.77–1.02; Ptrend = 0.03) comparing women with ≥ 72 metabolic equivalent of tasks-hours/week (MET-h/week) to < 21 MET-h/week. Women with high physical activity during both adolescence (≥53.3 MET-h/week) and adulthood (≥23.1 MET-h/week) had significantly lower risk of adenoma (all adenomas: OR 0.76; 95% CI 0.66–0.88; advanced adenoma: OR 0.61; 95% CI 0.45–0.82) compared to women with low physical activity during both stages of life. Conclusions: Our findings suggest that physical activity during adolescence may lower the risk of colorectal adenoma later in life.

AB - Background: Physical activity during adulthood has been consistently associated with lower risk of colorectal cancers, but whether physical activity during adolescence may also play a role in colorectal carcinogenesis is unclear. Methods: We included 28,250 women in the Nurses’ Health Study II who provided data on physical activity during adolescence (ages 12–22 years) in 1997 and underwent lower bowel endoscopy (1998–2011). We used logistic regression models for clustered data to examine the association between physical activity during adolescence and risk of adenoma later in life. Results: Physical activity during adolescence was inversely associated with risk of colorectal adenoma (2373 cases), independent of physical activity during adulthood. The multivariable-adjusted odds ratio (OR) of adenoma was 0.89 (95% CI 0.77–1.02; Ptrend = 0.03) comparing women with ≥ 72 metabolic equivalent of tasks-hours/week (MET-h/week) to < 21 MET-h/week. Women with high physical activity during both adolescence (≥53.3 MET-h/week) and adulthood (≥23.1 MET-h/week) had significantly lower risk of adenoma (all adenomas: OR 0.76; 95% CI 0.66–0.88; advanced adenoma: OR 0.61; 95% CI 0.45–0.82) compared to women with low physical activity during both stages of life. Conclusions: Our findings suggest that physical activity during adolescence may lower the risk of colorectal adenoma later in life.

UR - http://www.scopus.com/inward/record.url?scp=85066905049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066905049&partnerID=8YFLogxK

U2 - 10.1038/s41416-019-0454-1

DO - 10.1038/s41416-019-0454-1

M3 - Article

C2 - 31114018

AN - SCOPUS:85066905049

SN - 0007-0920

VL - 121

SP - 86

EP - 94

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 1

ER -

Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses’ Health Study II

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this