Physical activity during pregnancy and adverse birth outcome: a prospective cohort study in China

Jinxiu Li; Dongping Huang; Jun Liang; Jiehua Chen; Lei Lei; Mengrui Lin; Kaili Wu; Suyang Xiao; Mingshuang Lai; Xiaoqiang Qiu; Zhengmin Qian; Michael G. Vaughn; Stephen Edward McMillin; Guang Hui Dong; Xiaoyun Zeng; Shun Liu

doi:10.1080/14767058.2022.2162819

Physical activity during pregnancy and adverse birth outcome: a prospective cohort study in China

Jinxiu Li, Dongping Huang, Jun Liang, Jiehua Chen, Lei Lei, Mengrui Lin, Kaili Wu, Suyang Xiao, Mingshuang Lai, Xiaoqiang Qiu, Zhengmin Qian, Michael G. Vaughn, Stephen Edward McMillin, Guang Hui Dong, Xiaoyun Zeng, Shun Liu

Graduate School of Social Welfare

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives The relationship between prenatal physical activity (PA) and adverse birth outcomes is still inconclusive. We aimed to investigate the association between PA during pregnancy and adverse birth outcomes by using data from the Guangxi Zhuang birth cohort (GZBC) in China. Study Design A total of 11,292 mother-infant pairs were included from GZBC in China. The information on PA status, intensity, adequacy, and volume and birth outcomes were collected. Multivariable linear and logistic regression models were applied to analyze the effects of PA during pregnancy on birth weight z-scores (BW z-scores) and gestational age and risk of small-for-gestational age (SGA) and preterm birth (PTB), respectively. Cubic spline analysis was conducted to detect a nonlinear dose-response of total weekly activity metabolic equivalents (MET) and birth outcomes. Results Compared to no regular PA during pregnancy, moderate and high-intensity PA (MVPA) was associated with increase BW z-scores (β = 0.08, 95%CI: 0.002, 0.15, p =.044) and associated with a marginal significant decrease in risk of PTB (OR = 0.73, 95%CI: 0.51, 1.05, p =.093). However, PA had no relationship with gestational age and risk of SGA, and Nonlinear relationships were not observed between total weekly activity MET and risk of SGA and PTB. Conclusion These finding shows that PA during pregnancy may increase the BW z-score and reduce risk of PTB, supporting the guidelines that pregnant women should be encouraged to engage in appropriate physical activity during pregnancy in China.

Original language	English
Article number	2162819
Journal	Journal of Maternal-Fetal and Neonatal Medicine
Volume	36
Issue number	1
DOIs	https://doi.org/10.1080/14767058.2022.2162819
Publication status	Published - 2023

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China [82160623, 81460517 and 81860587], and Guangxi Key Research and Development Program [AB17195012]. This study is the result of the joint efforts of many people and institutions. We acknowledge the participants for their support and the study staff for their contributions in the study. We are very grateful to the following institutions for their strong support and cooperation: Tiandong People’s Hospital, Tiandong Maternity and Child Health Care Hospital, Jingxi People’s Hospital, Jingxi Maternity and Child Health Care Hospital, Pingguo People’s Hospital, Pingguo Maternity and Child Health Care Hospital, Debao People’s Hospital, Debao Maternity and Child Health Care Hospital, Longan People’s Hospital, Wuming People’s Hospital, Wuming Maternity and Child Health Care Hospital, and Clinical Epidemiology Research Center for Complex Diseases of Guangxi Medical University.

Publisher Copyright:
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynaecology

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10.1080/14767058.2022.2162819

Cite this

Li, J., Huang, D., Liang, J., Chen, J., Lei, L., Lin, M., Wu, K., Xiao, S., Lai, M., Qiu, X., Qian, Z., Vaughn, M. G., McMillin, S. E., Dong, G. H., Zeng, X., & Liu, S. (2023). Physical activity during pregnancy and adverse birth outcome: a prospective cohort study in China. Journal of Maternal-Fetal and Neonatal Medicine, 36(1), [2162819]. https://doi.org/10.1080/14767058.2022.2162819

@article{4f1833e4877e44e99931a405f9f80c91,

title = "Physical activity during pregnancy and adverse birth outcome: a prospective cohort study in China",

abstract = "Objectives The relationship between prenatal physical activity (PA) and adverse birth outcomes is still inconclusive. We aimed to investigate the association between PA during pregnancy and adverse birth outcomes by using data from the Guangxi Zhuang birth cohort (GZBC) in China. Study Design A total of 11,292 mother-infant pairs were included from GZBC in China. The information on PA status, intensity, adequacy, and volume and birth outcomes were collected. Multivariable linear and logistic regression models were applied to analyze the effects of PA during pregnancy on birth weight z-scores (BW z-scores) and gestational age and risk of small-for-gestational age (SGA) and preterm birth (PTB), respectively. Cubic spline analysis was conducted to detect a nonlinear dose-response of total weekly activity metabolic equivalents (MET) and birth outcomes. Results Compared to no regular PA during pregnancy, moderate and high-intensity PA (MVPA) was associated with increase BW z-scores (β = 0.08, 95%CI: 0.002, 0.15, p =.044) and associated with a marginal significant decrease in risk of PTB (OR = 0.73, 95%CI: 0.51, 1.05, p =.093). However, PA had no relationship with gestational age and risk of SGA, and Nonlinear relationships were not observed between total weekly activity MET and risk of SGA and PTB. Conclusion These finding shows that PA during pregnancy may increase the BW z-score and reduce risk of PTB, supporting the guidelines that pregnant women should be encouraged to engage in appropriate physical activity during pregnancy in China.",

author = "Jinxiu Li and Dongping Huang and Jun Liang and Jiehua Chen and Lei Lei and Mengrui Lin and Kaili Wu and Suyang Xiao and Mingshuang Lai and Xiaoqiang Qiu and Zhengmin Qian and Vaughn, {Michael G.} and McMillin, {Stephen Edward} and Dong, {Guang Hui} and Xiaoyun Zeng and Shun Liu",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China [82160623, 81460517 and 81860587], and Guangxi Key Research and Development Program [AB17195012]. This study is the result of the joint efforts of many people and institutions. We acknowledge the participants for their support and the study staff for their contributions in the study. We are very grateful to the following institutions for their strong support and cooperation: Tiandong People{\textquoteright}s Hospital, Tiandong Maternity and Child Health Care Hospital, Jingxi People{\textquoteright}s Hospital, Jingxi Maternity and Child Health Care Hospital, Pingguo People{\textquoteright}s Hospital, Pingguo Maternity and Child Health Care Hospital, Debao People{\textquoteright}s Hospital, Debao Maternity and Child Health Care Hospital, Longan People{\textquoteright}s Hospital, Wuming People{\textquoteright}s Hospital, Wuming Maternity and Child Health Care Hospital, and Clinical Epidemiology Research Center for Complex Diseases of Guangxi Medical University. Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",

year = "2023",

doi = "10.1080/14767058.2022.2162819",

language = "English",

volume = "36",

journal = "Journal of Maternal-Fetal and Neonatal Medicine",

issn = "1476-7058",

publisher = "Informa Healthcare",

number = "1",

}

Li, J, Huang, D, Liang, J, Chen, J, Lei, L, Lin, M, Wu, K, Xiao, S, Lai, M, Qiu, X, Qian, Z, Vaughn, MG, McMillin, SE, Dong, GH, Zeng, X & Liu, S 2023, 'Physical activity during pregnancy and adverse birth outcome: a prospective cohort study in China', Journal of Maternal-Fetal and Neonatal Medicine, vol. 36, no. 1, 2162819. https://doi.org/10.1080/14767058.2022.2162819

TY - JOUR

T1 - Physical activity during pregnancy and adverse birth outcome

T2 - a prospective cohort study in China

AU - Li, Jinxiu

AU - Huang, Dongping

AU - Liang, Jun

AU - Chen, Jiehua

AU - Lei, Lei

AU - Lin, Mengrui

AU - Wu, Kaili

AU - Xiao, Suyang

AU - Lai, Mingshuang

AU - Qiu, Xiaoqiang

AU - Qian, Zhengmin

AU - Vaughn, Michael G.

AU - McMillin, Stephen Edward

AU - Dong, Guang Hui

AU - Zeng, Xiaoyun

AU - Liu, Shun

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China [82160623, 81460517 and 81860587], and Guangxi Key Research and Development Program [AB17195012]. This study is the result of the joint efforts of many people and institutions. We acknowledge the participants for their support and the study staff for their contributions in the study. We are very grateful to the following institutions for their strong support and cooperation: Tiandong People’s Hospital, Tiandong Maternity and Child Health Care Hospital, Jingxi People’s Hospital, Jingxi Maternity and Child Health Care Hospital, Pingguo People’s Hospital, Pingguo Maternity and Child Health Care Hospital, Debao People’s Hospital, Debao Maternity and Child Health Care Hospital, Longan People’s Hospital, Wuming People’s Hospital, Wuming Maternity and Child Health Care Hospital, and Clinical Epidemiology Research Center for Complex Diseases of Guangxi Medical University. Publisher Copyright: © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

PY - 2023

Y1 - 2023

N2 - Objectives The relationship between prenatal physical activity (PA) and adverse birth outcomes is still inconclusive. We aimed to investigate the association between PA during pregnancy and adverse birth outcomes by using data from the Guangxi Zhuang birth cohort (GZBC) in China. Study Design A total of 11,292 mother-infant pairs were included from GZBC in China. The information on PA status, intensity, adequacy, and volume and birth outcomes were collected. Multivariable linear and logistic regression models were applied to analyze the effects of PA during pregnancy on birth weight z-scores (BW z-scores) and gestational age and risk of small-for-gestational age (SGA) and preterm birth (PTB), respectively. Cubic spline analysis was conducted to detect a nonlinear dose-response of total weekly activity metabolic equivalents (MET) and birth outcomes. Results Compared to no regular PA during pregnancy, moderate and high-intensity PA (MVPA) was associated with increase BW z-scores (β = 0.08, 95%CI: 0.002, 0.15, p =.044) and associated with a marginal significant decrease in risk of PTB (OR = 0.73, 95%CI: 0.51, 1.05, p =.093). However, PA had no relationship with gestational age and risk of SGA, and Nonlinear relationships were not observed between total weekly activity MET and risk of SGA and PTB. Conclusion These finding shows that PA during pregnancy may increase the BW z-score and reduce risk of PTB, supporting the guidelines that pregnant women should be encouraged to engage in appropriate physical activity during pregnancy in China.

AB - Objectives The relationship between prenatal physical activity (PA) and adverse birth outcomes is still inconclusive. We aimed to investigate the association between PA during pregnancy and adverse birth outcomes by using data from the Guangxi Zhuang birth cohort (GZBC) in China. Study Design A total of 11,292 mother-infant pairs were included from GZBC in China. The information on PA status, intensity, adequacy, and volume and birth outcomes were collected. Multivariable linear and logistic regression models were applied to analyze the effects of PA during pregnancy on birth weight z-scores (BW z-scores) and gestational age and risk of small-for-gestational age (SGA) and preterm birth (PTB), respectively. Cubic spline analysis was conducted to detect a nonlinear dose-response of total weekly activity metabolic equivalents (MET) and birth outcomes. Results Compared to no regular PA during pregnancy, moderate and high-intensity PA (MVPA) was associated with increase BW z-scores (β = 0.08, 95%CI: 0.002, 0.15, p =.044) and associated with a marginal significant decrease in risk of PTB (OR = 0.73, 95%CI: 0.51, 1.05, p =.093). However, PA had no relationship with gestational age and risk of SGA, and Nonlinear relationships were not observed between total weekly activity MET and risk of SGA and PTB. Conclusion These finding shows that PA during pregnancy may increase the BW z-score and reduce risk of PTB, supporting the guidelines that pregnant women should be encouraged to engage in appropriate physical activity during pregnancy in China.

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U2 - 10.1080/14767058.2022.2162819

DO - 10.1080/14767058.2022.2162819

M3 - Article

C2 - 36597826

AN - SCOPUS:85145428541

SN - 1476-7058

VL - 36

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

IS - 1

M1 - 2162819

ER -

Physical activity during pregnancy and adverse birth outcome: a prospective cohort study in China

Abstract

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