Physiochemical properties and resorption progress of porcine skin-derived collagen membranes

In vitro and in vivo analysis

Yin Zhe An, You Kyoung Kim, Su Min Lim, Yeong Ku Heo, Mi Kyung Kwon, Jae Kook Cha, Jung Seok Lee, Ui-Won Jung, Seongho Choi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of the present study was to evaluate the physiochemical properties and resorption progress of two cross-linked, porcine skin-derived collagen membranes and compare their features with those of a membrane without cross-linking (Bio-Gide® [BG], Geistlich Biomaterials, Wolhusen, Switzerland). Three porcine skin-derived collagen membranes, dehydrothermally (DHT) cross-linked (experimental), DHT and 1-ethyl-3(3-dimethylaminopropyl)-carbodiimide (DHT/EDC) cross-linked (experimental) and BG were investigated for their morphology, enzyme resistance, and tensile strength in vitro and biodegradation in vivo. DHT and DHT/ EDC membranes exhibited irregular, interconnected macro- and micropores that formed a 3D mesh, whereas BG exhibited individual collagen fibrils interlaced to form coarse collagen strands. In enzyme resistance and tensile strength tests, DHT and DHT/EDC membranes demonstrated good resistance and mechanical properties compared with BG. In vivo, all three membranes were well integrated into the surrounding connective tissue. Thus, the DHT membrane exhibited its potential as a barrier membrane for guided bone and tissue regeneration.

Original languageEnglish
Article numberdmj/2017-065
Pages (from-to)332-340
Number of pages9
JournalDental Materials Journal
Volume37
Issue number2
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Collagen
Skin
Swine
Membranes
Tensile Strength
Tensile strength
Enzymes
Ethyldimethylaminopropyl Carbodiimide
Guided Tissue Regeneration
Tissue regeneration
Bone Regeneration
In Vitro Techniques
Biocompatible Materials
Biodegradation
Switzerland
Biomaterials
Connective Tissue
Macros
Bone
Tissue

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Dentistry(all)

Cite this

An, Yin Zhe ; Kim, You Kyoung ; Lim, Su Min ; Heo, Yeong Ku ; Kwon, Mi Kyung ; Cha, Jae Kook ; Lee, Jung Seok ; Jung, Ui-Won ; Choi, Seongho. / Physiochemical properties and resorption progress of porcine skin-derived collagen membranes : In vitro and in vivo analysis. In: Dental Materials Journal. 2018 ; Vol. 37, No. 2. pp. 332-340.
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Physiochemical properties and resorption progress of porcine skin-derived collagen membranes : In vitro and in vivo analysis. / An, Yin Zhe; Kim, You Kyoung; Lim, Su Min; Heo, Yeong Ku; Kwon, Mi Kyung; Cha, Jae Kook; Lee, Jung Seok; Jung, Ui-Won; Choi, Seongho.

In: Dental Materials Journal, Vol. 37, No. 2, dmj/2017-065, 01.01.2018, p. 332-340.

Research output: Contribution to journalArticle

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