PI-RADS version 2Preoperative role in the detection of normal-sized pelvic lymph node metastasis in prostate cancer

Sung Yoon Park, Su Jin Shin, Dae Chul Jung, Namhoon Cho, Youngdeuk Choi, KoonHo Rha, Sung Joon Hong, Young Taik Oh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives To analyze whether Prostate Imaging Reporting and Data System (PI-RADSv2) scores are associated with a risk of normal-sized pelvic lymph node metastasis (PLNM) in prostate cancer (PCa). Materials and methods A consecutive series of 221 patients who underwent magnetic resonance imaging and radical prostatectomy with pelvic lymph node dissection (PLND) for PCa were retrospectively analyzed under the approval of institutional review board in our institution. No patients had enlarged (≥0.8 cm in short-axis diameter) lymph nodes. Clinical parameters [prostate-specific antigen (PSA), greatest percentage of biopsy core, and percentage of positive cores], and PI-RADSv2 score from two independent readers were analyzed with multivariate logistic regression and receiver operating-characteristic curve for PLNM. Diagnostic performance of PI-RADSv2 and Briganti nomogram was compared. Weighted kappa was investigated regarding PI-RADSv2 scoring. Results Normal-sized PLNM was found in 9.5% (21/221) of patients. In multivariate analysis, PI-RADSv2 (reader 1, p = 0.009; reader 2, p = 0.026) and PSA (reader 1, p = 0.008; reader 2, p = 0.037) were predictive of normal-sized PLNM. Threshold of PI-RADSv2 was a score of 5, where PI-RADSv2 was associated with high sensitivity (reader 1, 95.2% [20/21]; reader 2, 90.5% [19/21]) and negative predictive value (reader 1, 99.2% [124/125]; reader 2, 98.6% [136/138]). However, diagnostic performance of PI-RADSv2 (AUC = 0.786–0.788) was significantly lower than that of Briganti nomogram (AUC = 0.890) for normal-sized PLNM (p < 0.05). The inter-reader agreement was excellent for PI-RADSv2 of 5 or not (weighted kappa = 0.804). Conclusion PI-RADSv2 scores may be associated with the risk of normal-sized PLNM in PCa.

Original languageEnglish
Pages (from-to)22-28
Number of pages7
JournalEuropean Journal of Radiology
Volume91
DOIs
Publication statusPublished - 2017 Jun 1

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Prostatic Neoplasms
Lymph Nodes
Neoplasm Metastasis
Nomograms
Prostate-Specific Antigen
Area Under Curve
Research Ethics Committees
Prostatectomy
Lymph Node Excision
Information Systems
ROC Curve
Prostate
Multivariate Analysis
Logistic Models
Magnetic Resonance Imaging
Biopsy

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

@article{e263563bfbb440ba8a8e971079d638c7,
title = "PI-RADS version 2Preoperative role in the detection of normal-sized pelvic lymph node metastasis in prostate cancer",
abstract = "Objectives To analyze whether Prostate Imaging Reporting and Data System (PI-RADSv2) scores are associated with a risk of normal-sized pelvic lymph node metastasis (PLNM) in prostate cancer (PCa). Materials and methods A consecutive series of 221 patients who underwent magnetic resonance imaging and radical prostatectomy with pelvic lymph node dissection (PLND) for PCa were retrospectively analyzed under the approval of institutional review board in our institution. No patients had enlarged (≥0.8 cm in short-axis diameter) lymph nodes. Clinical parameters [prostate-specific antigen (PSA), greatest percentage of biopsy core, and percentage of positive cores], and PI-RADSv2 score from two independent readers were analyzed with multivariate logistic regression and receiver operating-characteristic curve for PLNM. Diagnostic performance of PI-RADSv2 and Briganti nomogram was compared. Weighted kappa was investigated regarding PI-RADSv2 scoring. Results Normal-sized PLNM was found in 9.5{\%} (21/221) of patients. In multivariate analysis, PI-RADSv2 (reader 1, p = 0.009; reader 2, p = 0.026) and PSA (reader 1, p = 0.008; reader 2, p = 0.037) were predictive of normal-sized PLNM. Threshold of PI-RADSv2 was a score of 5, where PI-RADSv2 was associated with high sensitivity (reader 1, 95.2{\%} [20/21]; reader 2, 90.5{\%} [19/21]) and negative predictive value (reader 1, 99.2{\%} [124/125]; reader 2, 98.6{\%} [136/138]). However, diagnostic performance of PI-RADSv2 (AUC = 0.786–0.788) was significantly lower than that of Briganti nomogram (AUC = 0.890) for normal-sized PLNM (p < 0.05). The inter-reader agreement was excellent for PI-RADSv2 of 5 or not (weighted kappa = 0.804). Conclusion PI-RADSv2 scores may be associated with the risk of normal-sized PLNM in PCa.",
author = "Park, {Sung Yoon} and Shin, {Su Jin} and Jung, {Dae Chul} and Namhoon Cho and Youngdeuk Choi and KoonHo Rha and Hong, {Sung Joon} and Oh, {Young Taik}",
year = "2017",
month = "6",
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doi = "10.1016/j.ejrad.2017.03.009",
language = "English",
volume = "91",
pages = "22--28",
journal = "European Journal of Radiology",
issn = "0720-048X",
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PI-RADS version 2Preoperative role in the detection of normal-sized pelvic lymph node metastasis in prostate cancer. / Park, Sung Yoon; Shin, Su Jin; Jung, Dae Chul; Cho, Namhoon; Choi, Youngdeuk; Rha, KoonHo; Hong, Sung Joon; Oh, Young Taik.

In: European Journal of Radiology, Vol. 91, 01.06.2017, p. 22-28.

Research output: Contribution to journalArticle

TY - JOUR

T1 - PI-RADS version 2Preoperative role in the detection of normal-sized pelvic lymph node metastasis in prostate cancer

AU - Park, Sung Yoon

AU - Shin, Su Jin

AU - Jung, Dae Chul

AU - Cho, Namhoon

AU - Choi, Youngdeuk

AU - Rha, KoonHo

AU - Hong, Sung Joon

AU - Oh, Young Taik

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Objectives To analyze whether Prostate Imaging Reporting and Data System (PI-RADSv2) scores are associated with a risk of normal-sized pelvic lymph node metastasis (PLNM) in prostate cancer (PCa). Materials and methods A consecutive series of 221 patients who underwent magnetic resonance imaging and radical prostatectomy with pelvic lymph node dissection (PLND) for PCa were retrospectively analyzed under the approval of institutional review board in our institution. No patients had enlarged (≥0.8 cm in short-axis diameter) lymph nodes. Clinical parameters [prostate-specific antigen (PSA), greatest percentage of biopsy core, and percentage of positive cores], and PI-RADSv2 score from two independent readers were analyzed with multivariate logistic regression and receiver operating-characteristic curve for PLNM. Diagnostic performance of PI-RADSv2 and Briganti nomogram was compared. Weighted kappa was investigated regarding PI-RADSv2 scoring. Results Normal-sized PLNM was found in 9.5% (21/221) of patients. In multivariate analysis, PI-RADSv2 (reader 1, p = 0.009; reader 2, p = 0.026) and PSA (reader 1, p = 0.008; reader 2, p = 0.037) were predictive of normal-sized PLNM. Threshold of PI-RADSv2 was a score of 5, where PI-RADSv2 was associated with high sensitivity (reader 1, 95.2% [20/21]; reader 2, 90.5% [19/21]) and negative predictive value (reader 1, 99.2% [124/125]; reader 2, 98.6% [136/138]). However, diagnostic performance of PI-RADSv2 (AUC = 0.786–0.788) was significantly lower than that of Briganti nomogram (AUC = 0.890) for normal-sized PLNM (p < 0.05). The inter-reader agreement was excellent for PI-RADSv2 of 5 or not (weighted kappa = 0.804). Conclusion PI-RADSv2 scores may be associated with the risk of normal-sized PLNM in PCa.

AB - Objectives To analyze whether Prostate Imaging Reporting and Data System (PI-RADSv2) scores are associated with a risk of normal-sized pelvic lymph node metastasis (PLNM) in prostate cancer (PCa). Materials and methods A consecutive series of 221 patients who underwent magnetic resonance imaging and radical prostatectomy with pelvic lymph node dissection (PLND) for PCa were retrospectively analyzed under the approval of institutional review board in our institution. No patients had enlarged (≥0.8 cm in short-axis diameter) lymph nodes. Clinical parameters [prostate-specific antigen (PSA), greatest percentage of biopsy core, and percentage of positive cores], and PI-RADSv2 score from two independent readers were analyzed with multivariate logistic regression and receiver operating-characteristic curve for PLNM. Diagnostic performance of PI-RADSv2 and Briganti nomogram was compared. Weighted kappa was investigated regarding PI-RADSv2 scoring. Results Normal-sized PLNM was found in 9.5% (21/221) of patients. In multivariate analysis, PI-RADSv2 (reader 1, p = 0.009; reader 2, p = 0.026) and PSA (reader 1, p = 0.008; reader 2, p = 0.037) were predictive of normal-sized PLNM. Threshold of PI-RADSv2 was a score of 5, where PI-RADSv2 was associated with high sensitivity (reader 1, 95.2% [20/21]; reader 2, 90.5% [19/21]) and negative predictive value (reader 1, 99.2% [124/125]; reader 2, 98.6% [136/138]). However, diagnostic performance of PI-RADSv2 (AUC = 0.786–0.788) was significantly lower than that of Briganti nomogram (AUC = 0.890) for normal-sized PLNM (p < 0.05). The inter-reader agreement was excellent for PI-RADSv2 of 5 or not (weighted kappa = 0.804). Conclusion PI-RADSv2 scores may be associated with the risk of normal-sized PLNM in PCa.

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JO - European Journal of Radiology

JF - European Journal of Radiology

SN - 0720-048X

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