Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission

Lee Farrand; Sanguine Byun; Ji Young Kim; Akechai Im-Aram; Jihoon Lee; Semi Lim; Ki Won Lee; Jeong Yong Suh; Hyong Joo Lee; Benjamin K. Tsang

doi:10.1074/jbc.M113.487686

Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission

Lee Farrand, Sanguine Byun, Ji Young Kim, Akechai Im-Aram, Jihoon Lee, Semi Lim, Ki Won Lee, Jeong Yong Suh, Hyong Joo Lee, Benjamin K. Tsang

Division of Life Sciences

Research output: Contribution to journal › Article

54 Citations (Scopus)

Abstract

Background: Chemotherapeutic sensitivity in ovarian cancer is dependent on effective apoptosis signaling. Results: Piceatannol enhances cisplatin sensitivity by modulating p53, XIAP (X-linked inhibitor of apoptosis protein), and mitochondrial fission in vitro and in vivo. Conclusion: Piceatannol is a potent enhancer of cisplatin-induced apoptosis. Significance: Piceatannol exhibits potential for clinical development for the treatment of ovarian cancer.

Original language	English
Pages (from-to)	23740-23750
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	33
DOIs	https://doi.org/10.1074/jbc.M113.487686
Publication status	Published - 2013 Aug 16

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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Farrand, L., Byun, S., Kim, J. Y., Im-Aram, A., Lee, J., Lim, S., Lee, K. W., Suh, J. Y., Lee, H. J., & Tsang, B. K. (2013). Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission. Journal of Biological Chemistry, 288(33), 23740-23750. https://doi.org/10.1074/jbc.M113.487686

Farrand, Lee ; Byun, Sanguine ; Kim, Ji Young ; Im-Aram, Akechai ; Lee, Jihoon ; Lim, Semi ; Lee, Ki Won ; Suh, Jeong Yong ; Lee, Hyong Joo ; Tsang, Benjamin K. / Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 33. pp. 23740-23750.

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title = "Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission",

abstract = "Background: Chemotherapeutic sensitivity in ovarian cancer is dependent on effective apoptosis signaling. Results: Piceatannol enhances cisplatin sensitivity by modulating p53, XIAP (X-linked inhibitor of apoptosis protein), and mitochondrial fission in vitro and in vivo. Conclusion: Piceatannol is a potent enhancer of cisplatin-induced apoptosis. Significance: Piceatannol exhibits potential for clinical development for the treatment of ovarian cancer.",

author = "Lee Farrand and Sanguine Byun and Kim, {Ji Young} and Akechai Im-Aram and Jihoon Lee and Semi Lim and Lee, {Ki Won} and Suh, {Jeong Yong} and Lee, {Hyong Joo} and Tsang, {Benjamin K.}",

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doi = "10.1074/jbc.M113.487686",

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Farrand, L, Byun, S, Kim, JY, Im-Aram, A, Lee, J, Lim, S, Lee, KW, Suh, JY, Lee, HJ & Tsang, BK 2013, 'Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission', Journal of Biological Chemistry, vol. 288, no. 33, pp. 23740-23750. https://doi.org/10.1074/jbc.M113.487686

Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission. / Farrand, Lee; Byun, Sanguine; Kim, Ji Young; Im-Aram, Akechai; Lee, Jihoon; Lim, Semi; Lee, Ki Won; Suh, Jeong Yong; Lee, Hyong Joo; Tsang, Benjamin K.

In: Journal of Biological Chemistry, Vol. 288, No. 33, 16.08.2013, p. 23740-23750.

Research output: Contribution to journal › Article

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AU - Farrand, Lee

AU - Byun, Sanguine

AU - Kim, Ji Young

AU - Im-Aram, Akechai

AU - Lee, Jihoon

AU - Lim, Semi

AU - Lee, Ki Won

AU - Suh, Jeong Yong

AU - Lee, Hyong Joo

AU - Tsang, Benjamin K.

PY - 2013/8/16

Y1 - 2013/8/16

N2 - Background: Chemotherapeutic sensitivity in ovarian cancer is dependent on effective apoptosis signaling. Results: Piceatannol enhances cisplatin sensitivity by modulating p53, XIAP (X-linked inhibitor of apoptosis protein), and mitochondrial fission in vitro and in vivo. Conclusion: Piceatannol is a potent enhancer of cisplatin-induced apoptosis. Significance: Piceatannol exhibits potential for clinical development for the treatment of ovarian cancer.

AB - Background: Chemotherapeutic sensitivity in ovarian cancer is dependent on effective apoptosis signaling. Results: Piceatannol enhances cisplatin sensitivity by modulating p53, XIAP (X-linked inhibitor of apoptosis protein), and mitochondrial fission in vitro and in vivo. Conclusion: Piceatannol is a potent enhancer of cisplatin-induced apoptosis. Significance: Piceatannol exhibits potential for clinical development for the treatment of ovarian cancer.

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