Pilot trial of yttrium-90 ibritumomab tiuxetan consolidation following rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy in patients with limited-stage, bulky diffuse large B-cell lymphoma

Deok Hwan Yang, Won Seog Kim, Seok Jin Kim, Jin Seok Kim, Jae Yong Kwak, Joo Seop Chung, Sung Yong Oh, Cheolwon Suh, Je Jung Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The clinical efficacy and safety of yttrium-90 ( 90Y)-ibritumomab tiuxetan consolidation treatment following rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) chemotherapy was investigated in patients with limited-stage and bulky diffuse large B-cell lymphoma (DLBCL). This prospective, multi-center, pilot trial included 21 patients who were newly diagnosed with stage I/II, bulky DLBCL and achieved a complete or partial response after six cycles of R-CHOP. The median size of bulky disease was 10.0 × 7.0 cm. After a median follow-up of 28.8 months, the overall response rate after 90Y-ibritumomab tiuxetan consolidation treatment was 80.9%, including 4.8% partial response. However, six patients (28.6%) experienced a progression or relapse. The 3-year overall and progression-free survival rates were 85.0 ± 8.0% and 75.0 ± 9.7%, respectively. Grade 34 adverse events were mainly hematologic toxicities, such as thrombocytopenia (35%) and neutropenia (60%). One patient experienced grade 3 Pneumocystis carinii pneumonitis. Thus, 90Y-ibritumomab tiuxetan consolidation following six cycles of R-CHOP resulted in an acceptable response with tolerable toxicity in patients with limited-stage and bulky DLBCL.

Original languageEnglish
Pages (from-to)807-811
Number of pages5
JournalLeukemia and Lymphoma
Volume53
Issue number5
DOIs
Publication statusPublished - 2012 May

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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