Pituitary 18F-FDG Uptake Correlates with Serum TSH Levels in Subjects with Diffuse Thyroid 18F-FDG Uptake

Yong Hyu Jeong, Dongwoo Kim, Jeong Won Lee, Yumie Rhee, Kee Hyun Nam, Mijin Yun, Chun Ki Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose This study was to evaluate the relationship among FDG uptake in the pituitary gland (FDGp), FDG uptake in the thyroid gland (FDGt), and serum thyroid-stimulating hormone (TSH) levels in patients with diffuse FDGt incidentally noted on positron emission tomography/computed tomography (PET/CT). Patients and Methods We retrospectively reviewed FDG PET/CT scans of 2,945 subjects who underwent health screening. Of these, 44 subjects had diffuse FDGt and available thyroid function tests. FDGt and FDGp were correlated with serum TSH. FDGp in 44 paired control subjects without FDGt and 15 thyroid cancer patients undergoing thyroid hormone withdrawal were additionally measured, and compared with FDGp in the 44 subjects with FDGt divided into 3 groups according to serum TSH levels. Results In the 44 subjects, there was a strong correlation found between FDGp and TSH (P < 0.001, r = 0.618). As well, there were statistically significant differences in FDGp between the low, normal, and high TSH groups (P < 0.001). FDGp in the paired control subjects was not different from that in the normal TSH group (P = 0.384), and FDGp in the TSH-stimulated thyroid cancer patients was not different from that in the high TSH group (P = 0.463). Conclusion We found a strong positive correlation between pituitary FDG uptake and serum TSH. Pituitary FDG uptake seems to hold an important clue to the functional status of the thyroid in subjects with diffuse thyroid FDG uptake. Furthermore, physiologic FDG uptake in the pituitary gland caused by hypothyroidism should not be confused with pathologic conditions such as macroadenoma or metastases.

Original languageEnglish
Pages (from-to)632-636
Number of pages5
JournalClinical nuclear medicine
Volume40
Issue number8
DOIs
Publication statusPublished - 2015 Aug 30

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Fluorodeoxyglucose F18
Thyrotropin
Thyroid Gland
Serum
Pituitary Gland
Thyroid Neoplasms
Thyroid Function Tests
Hypothyroidism
Thyroid Hormones
Neoplasm Metastasis
Health

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Jeong, Yong Hyu ; Kim, Dongwoo ; Lee, Jeong Won ; Rhee, Yumie ; Nam, Kee Hyun ; Yun, Mijin ; Kim, Chun Ki. / Pituitary 18F-FDG Uptake Correlates with Serum TSH Levels in Subjects with Diffuse Thyroid 18F-FDG Uptake. In: Clinical nuclear medicine. 2015 ; Vol. 40, No. 8. pp. 632-636.
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title = "Pituitary 18F-FDG Uptake Correlates with Serum TSH Levels in Subjects with Diffuse Thyroid 18F-FDG Uptake",
abstract = "Purpose This study was to evaluate the relationship among FDG uptake in the pituitary gland (FDGp), FDG uptake in the thyroid gland (FDGt), and serum thyroid-stimulating hormone (TSH) levels in patients with diffuse FDGt incidentally noted on positron emission tomography/computed tomography (PET/CT). Patients and Methods We retrospectively reviewed FDG PET/CT scans of 2,945 subjects who underwent health screening. Of these, 44 subjects had diffuse FDGt and available thyroid function tests. FDGt and FDGp were correlated with serum TSH. FDGp in 44 paired control subjects without FDGt and 15 thyroid cancer patients undergoing thyroid hormone withdrawal were additionally measured, and compared with FDGp in the 44 subjects with FDGt divided into 3 groups according to serum TSH levels. Results In the 44 subjects, there was a strong correlation found between FDGp and TSH (P < 0.001, r = 0.618). As well, there were statistically significant differences in FDGp between the low, normal, and high TSH groups (P < 0.001). FDGp in the paired control subjects was not different from that in the normal TSH group (P = 0.384), and FDGp in the TSH-stimulated thyroid cancer patients was not different from that in the high TSH group (P = 0.463). Conclusion We found a strong positive correlation between pituitary FDG uptake and serum TSH. Pituitary FDG uptake seems to hold an important clue to the functional status of the thyroid in subjects with diffuse thyroid FDG uptake. Furthermore, physiologic FDG uptake in the pituitary gland caused by hypothyroidism should not be confused with pathologic conditions such as macroadenoma or metastases.",
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Pituitary 18F-FDG Uptake Correlates with Serum TSH Levels in Subjects with Diffuse Thyroid 18F-FDG Uptake. / Jeong, Yong Hyu; Kim, Dongwoo; Lee, Jeong Won; Rhee, Yumie; Nam, Kee Hyun; Yun, Mijin; Kim, Chun Ki.

In: Clinical nuclear medicine, Vol. 40, No. 8, 30.08.2015, p. 632-636.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pituitary 18F-FDG Uptake Correlates with Serum TSH Levels in Subjects with Diffuse Thyroid 18F-FDG Uptake

AU - Jeong, Yong Hyu

AU - Kim, Dongwoo

AU - Lee, Jeong Won

AU - Rhee, Yumie

AU - Nam, Kee Hyun

AU - Yun, Mijin

AU - Kim, Chun Ki

PY - 2015/8/30

Y1 - 2015/8/30

N2 - Purpose This study was to evaluate the relationship among FDG uptake in the pituitary gland (FDGp), FDG uptake in the thyroid gland (FDGt), and serum thyroid-stimulating hormone (TSH) levels in patients with diffuse FDGt incidentally noted on positron emission tomography/computed tomography (PET/CT). Patients and Methods We retrospectively reviewed FDG PET/CT scans of 2,945 subjects who underwent health screening. Of these, 44 subjects had diffuse FDGt and available thyroid function tests. FDGt and FDGp were correlated with serum TSH. FDGp in 44 paired control subjects without FDGt and 15 thyroid cancer patients undergoing thyroid hormone withdrawal were additionally measured, and compared with FDGp in the 44 subjects with FDGt divided into 3 groups according to serum TSH levels. Results In the 44 subjects, there was a strong correlation found between FDGp and TSH (P < 0.001, r = 0.618). As well, there were statistically significant differences in FDGp between the low, normal, and high TSH groups (P < 0.001). FDGp in the paired control subjects was not different from that in the normal TSH group (P = 0.384), and FDGp in the TSH-stimulated thyroid cancer patients was not different from that in the high TSH group (P = 0.463). Conclusion We found a strong positive correlation between pituitary FDG uptake and serum TSH. Pituitary FDG uptake seems to hold an important clue to the functional status of the thyroid in subjects with diffuse thyroid FDG uptake. Furthermore, physiologic FDG uptake in the pituitary gland caused by hypothyroidism should not be confused with pathologic conditions such as macroadenoma or metastases.

AB - Purpose This study was to evaluate the relationship among FDG uptake in the pituitary gland (FDGp), FDG uptake in the thyroid gland (FDGt), and serum thyroid-stimulating hormone (TSH) levels in patients with diffuse FDGt incidentally noted on positron emission tomography/computed tomography (PET/CT). Patients and Methods We retrospectively reviewed FDG PET/CT scans of 2,945 subjects who underwent health screening. Of these, 44 subjects had diffuse FDGt and available thyroid function tests. FDGt and FDGp were correlated with serum TSH. FDGp in 44 paired control subjects without FDGt and 15 thyroid cancer patients undergoing thyroid hormone withdrawal were additionally measured, and compared with FDGp in the 44 subjects with FDGt divided into 3 groups according to serum TSH levels. Results In the 44 subjects, there was a strong correlation found between FDGp and TSH (P < 0.001, r = 0.618). As well, there were statistically significant differences in FDGp between the low, normal, and high TSH groups (P < 0.001). FDGp in the paired control subjects was not different from that in the normal TSH group (P = 0.384), and FDGp in the TSH-stimulated thyroid cancer patients was not different from that in the high TSH group (P = 0.463). Conclusion We found a strong positive correlation between pituitary FDG uptake and serum TSH. Pituitary FDG uptake seems to hold an important clue to the functional status of the thyroid in subjects with diffuse thyroid FDG uptake. Furthermore, physiologic FDG uptake in the pituitary gland caused by hypothyroidism should not be confused with pathologic conditions such as macroadenoma or metastases.

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