PIVKA-II is a useful tumor marker for recurrent hepatocellular carcinoma after surgical resection

doyoung kim, Yong Han Paik, SangHoon Ahn, Young Jun Youn, Jong Won Choi, Ja Kyung Kim, Kwan Sik Lee, Chae Yoon Chon, KwangHyub Han

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Objectives: The aim of this study is to assess the usefulness of prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II) in monitoring of recurrent hepatocellular carcinoma (HCC) after curative resection. Methods: From April 2001 to March 2004, a total of 245 patients with histologically proven HCC and 267 non-HCC patients were recruited. Serial follow-up measurements of both alpha-fetoprotein (AFP) and PIVKA-II were performed in 27 patients who had recurrent HCC after resection. Results: In the initial HCC diagnosis, the sensitivity of AFP and PIVKA-II was 48.6% (119/245) and 75.1% (184/245), respectively, at the cutoff of 20 ng/ml for AFP and 40 mAU/ml for PIVKA-II (p < 0.01). The specificity was 81.3% (217/267) and 94.8% (253/267), respectively. When AFP and PIVKA-II were combined, the sensitivity and specificity was 83.3% (204/245) and 77.2% (206/267), respectively. In 27 patients developing recurrent HCC after curative surgical resection, the sensitivity of AFP and PIVKA-II was 40.7% (11/27) and 74.1% (20/27), respectively. Several fluctuating patterns of AFP and PIVKA-II were observed from initial diagnosis to recurrence. Conclusion: Our data suggest that PIVKA-II is a useful tumor marker for HCC, complementary to AFP. Serial measurements of both markers after resection might be helpful for early diagnosis of tumor recurrence.

Original languageEnglish
Pages (from-to)52-57
Number of pages6
JournalOncology
Volume72
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2007 Dec 1

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Vitamin K
Prothrombin
Tumor Biomarkers
alpha-Fetoproteins
Hepatocellular Carcinoma
Recurrence
Early Diagnosis
Carcinoma
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

kim, doyoung ; Paik, Yong Han ; Ahn, SangHoon ; Youn, Young Jun ; Choi, Jong Won ; Kim, Ja Kyung ; Lee, Kwan Sik ; Chon, Chae Yoon ; Han, KwangHyub. / PIVKA-II is a useful tumor marker for recurrent hepatocellular carcinoma after surgical resection. In: Oncology. 2007 ; Vol. 72, No. SUPPL. 1. pp. 52-57.
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abstract = "Objectives: The aim of this study is to assess the usefulness of prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II) in monitoring of recurrent hepatocellular carcinoma (HCC) after curative resection. Methods: From April 2001 to March 2004, a total of 245 patients with histologically proven HCC and 267 non-HCC patients were recruited. Serial follow-up measurements of both alpha-fetoprotein (AFP) and PIVKA-II were performed in 27 patients who had recurrent HCC after resection. Results: In the initial HCC diagnosis, the sensitivity of AFP and PIVKA-II was 48.6{\%} (119/245) and 75.1{\%} (184/245), respectively, at the cutoff of 20 ng/ml for AFP and 40 mAU/ml for PIVKA-II (p < 0.01). The specificity was 81.3{\%} (217/267) and 94.8{\%} (253/267), respectively. When AFP and PIVKA-II were combined, the sensitivity and specificity was 83.3{\%} (204/245) and 77.2{\%} (206/267), respectively. In 27 patients developing recurrent HCC after curative surgical resection, the sensitivity of AFP and PIVKA-II was 40.7{\%} (11/27) and 74.1{\%} (20/27), respectively. Several fluctuating patterns of AFP and PIVKA-II were observed from initial diagnosis to recurrence. Conclusion: Our data suggest that PIVKA-II is a useful tumor marker for HCC, complementary to AFP. Serial measurements of both markers after resection might be helpful for early diagnosis of tumor recurrence.",
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PIVKA-II is a useful tumor marker for recurrent hepatocellular carcinoma after surgical resection. / kim, doyoung; Paik, Yong Han; Ahn, SangHoon; Youn, Young Jun; Choi, Jong Won; Kim, Ja Kyung; Lee, Kwan Sik; Chon, Chae Yoon; Han, KwangHyub.

In: Oncology, Vol. 72, No. SUPPL. 1, 01.12.2007, p. 52-57.

Research output: Contribution to journalArticle

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T1 - PIVKA-II is a useful tumor marker for recurrent hepatocellular carcinoma after surgical resection

AU - kim, doyoung

AU - Paik, Yong Han

AU - Ahn, SangHoon

AU - Youn, Young Jun

AU - Choi, Jong Won

AU - Kim, Ja Kyung

AU - Lee, Kwan Sik

AU - Chon, Chae Yoon

AU - Han, KwangHyub

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Objectives: The aim of this study is to assess the usefulness of prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II) in monitoring of recurrent hepatocellular carcinoma (HCC) after curative resection. Methods: From April 2001 to March 2004, a total of 245 patients with histologically proven HCC and 267 non-HCC patients were recruited. Serial follow-up measurements of both alpha-fetoprotein (AFP) and PIVKA-II were performed in 27 patients who had recurrent HCC after resection. Results: In the initial HCC diagnosis, the sensitivity of AFP and PIVKA-II was 48.6% (119/245) and 75.1% (184/245), respectively, at the cutoff of 20 ng/ml for AFP and 40 mAU/ml for PIVKA-II (p < 0.01). The specificity was 81.3% (217/267) and 94.8% (253/267), respectively. When AFP and PIVKA-II were combined, the sensitivity and specificity was 83.3% (204/245) and 77.2% (206/267), respectively. In 27 patients developing recurrent HCC after curative surgical resection, the sensitivity of AFP and PIVKA-II was 40.7% (11/27) and 74.1% (20/27), respectively. Several fluctuating patterns of AFP and PIVKA-II were observed from initial diagnosis to recurrence. Conclusion: Our data suggest that PIVKA-II is a useful tumor marker for HCC, complementary to AFP. Serial measurements of both markers after resection might be helpful for early diagnosis of tumor recurrence.

AB - Objectives: The aim of this study is to assess the usefulness of prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II) in monitoring of recurrent hepatocellular carcinoma (HCC) after curative resection. Methods: From April 2001 to March 2004, a total of 245 patients with histologically proven HCC and 267 non-HCC patients were recruited. Serial follow-up measurements of both alpha-fetoprotein (AFP) and PIVKA-II were performed in 27 patients who had recurrent HCC after resection. Results: In the initial HCC diagnosis, the sensitivity of AFP and PIVKA-II was 48.6% (119/245) and 75.1% (184/245), respectively, at the cutoff of 20 ng/ml for AFP and 40 mAU/ml for PIVKA-II (p < 0.01). The specificity was 81.3% (217/267) and 94.8% (253/267), respectively. When AFP and PIVKA-II were combined, the sensitivity and specificity was 83.3% (204/245) and 77.2% (206/267), respectively. In 27 patients developing recurrent HCC after curative surgical resection, the sensitivity of AFP and PIVKA-II was 40.7% (11/27) and 74.1% (20/27), respectively. Several fluctuating patterns of AFP and PIVKA-II were observed from initial diagnosis to recurrence. Conclusion: Our data suggest that PIVKA-II is a useful tumor marker for HCC, complementary to AFP. Serial measurements of both markers after resection might be helpful for early diagnosis of tumor recurrence.

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