Plaque ruptures in stable angina pectoris compared with acute coronary syndrome

Myeong Ki Hong, Gary S. Mintz, Cheol Whan Lee, Kyoung Min Park, Bong Ki Lee, Young Hak Kim, Duk Hyun Kang, Sang Sig Cheong, Jae Kwan Song, Jae Joong Kim, Seong Wook Park, Seung Jung Park

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Background: Plaque rupture is more frequently observed in patients with acute coronary syndrome (ACS) rather than in patients with stable angina pectoris (SAP). Consequently, studies regarding plaque rupture, which occurred in SAP patients, are rare. Therefore, we evaluated the frequency and axial location of plaque ruptures in SAP patients and compared them with those in ACS patients. Methods: Three hundred ninety-two patients (231 ACS and 161 SAP patients) who were scheduled for coronary intervention underwent three-vessel intravascular ultrasound (IVUS) study. IVUS criteria for plaque rupture were a plaque contained a cavity that communicated with the lumen with an overlying residual fibrous cap fragment. Using motorized IVUS transducer pullback in all three coronary arteries, the distance between each coronary plaque rupture segment and the respective coronary ostium was measured. Results: Plaque ruptures were detected in 206 of 392 patients who underwent three-vessel intravascular ultrasound examination. At least one plaque rupture in any coronary artery was noted in 48 (30%) SAP and 158 (68%) ACS patients (p < 0.001). In both ACS and SAP patients, plaque ruptures were clustered mainly in the proximal segments of the left anterior descending artery and in the proximal and distal segments of the right coronary artery. Conclusions: At least one plaque rupture in any coronary artery was noted in 30% of SAP patients. Like in ACS patients, plaque ruptures were clustered mainly in the proximal segments of the left anterior descending artery and in the proximal and distal segments of the right coronary artery in SAP patients.

Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalInternational Journal of Cardiology
Volume114
Issue number1
DOIs
Publication statusPublished - 2007 Jan 2

Bibliographical note

Funding Information:
This study was supported in part by the Cardiovascular Research Foundation, Seoul, Korea and a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Korea (0412-CR02-0704-0001).

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Plaque ruptures in stable angina pectoris compared with acute coronary syndrome'. Together they form a unique fingerprint.

Cite this