Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: Data from infarction prognosis study registry

Sang Hak Lee, Jong Won Ha, Jung Sun Kim, Eui Young Choi, Sungha Park, Seok Min Kang, Donghoon Choi, Yangsoo Jang, Namsik Chung

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Adiponectin and resistin, which have counteracting effects, are suggested to be associated with inflammation and atherosclerosis. The relationship between their levels and prognosis in high risk patients is, however, still unclear. The aim of this study was to evaluate the prognostic values of these adipokines in patients with acute myocardial infarction (MI). Methods: Adiponectin and resistin levels were measured at acute phase of MI in 397 consecutive patients. All patients were followed-up for the occurrence of all-cause and cardiovascular mortalities. Predictors for all-cause and cardiovascular mortalities were analyzed by Cox proportional hazard model. Results: During the mean follow-up period of 12 months, 28 (7.1%) patients died. Unadjusted all-cause mortality rate was significantly higher in patients with high tertiles of adiponectin (P = 0.002) and resistin (P = 0.002) levels. After controlling of clinical and laboratory variables, age [95% confidence interval (CI): 1.20-2.83, P = 0.006], adiponectin (95% CI: 1.01-1.22, P = 0.040), resistin (95% CI: 1.06-2.33, P = 0.025), and statin use (95% CI: 0.15-0.83, P = 0.017) were found to be independent predictors of all-cause mortality. For cardiovascular mortality, only age (95% CI: 1.33-3.25, P = 0.001) and renal insufficiency (95% CI: 1.52-12.22, P = 0.006) were independent predictors. Conclusion: High plasma adiponectin and resistin levels were predictors for all-cause mortality independent of other risk factors in patients with acute MI. These results confirmed and extended the positive correlations between these adipokines and mortality to a population consisting exclusively of MI.

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalCoronary artery disease
Volume20
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

Fingerprint

Resistin
Adiponectin
Infarction
Registries
Myocardial Infarction
Confidence Intervals
Mortality
Adipokines
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Proportional Hazards Models
Renal Insufficiency
Atherosclerosis
Inflammation

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{cc7d156852494790b1c8e3a79a9e8d9e,
title = "Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: Data from infarction prognosis study registry",
abstract = "Background: Adiponectin and resistin, which have counteracting effects, are suggested to be associated with inflammation and atherosclerosis. The relationship between their levels and prognosis in high risk patients is, however, still unclear. The aim of this study was to evaluate the prognostic values of these adipokines in patients with acute myocardial infarction (MI). Methods: Adiponectin and resistin levels were measured at acute phase of MI in 397 consecutive patients. All patients were followed-up for the occurrence of all-cause and cardiovascular mortalities. Predictors for all-cause and cardiovascular mortalities were analyzed by Cox proportional hazard model. Results: During the mean follow-up period of 12 months, 28 (7.1{\%}) patients died. Unadjusted all-cause mortality rate was significantly higher in patients with high tertiles of adiponectin (P = 0.002) and resistin (P = 0.002) levels. After controlling of clinical and laboratory variables, age [95{\%} confidence interval (CI): 1.20-2.83, P = 0.006], adiponectin (95{\%} CI: 1.01-1.22, P = 0.040), resistin (95{\%} CI: 1.06-2.33, P = 0.025), and statin use (95{\%} CI: 0.15-0.83, P = 0.017) were found to be independent predictors of all-cause mortality. For cardiovascular mortality, only age (95{\%} CI: 1.33-3.25, P = 0.001) and renal insufficiency (95{\%} CI: 1.52-12.22, P = 0.006) were independent predictors. Conclusion: High plasma adiponectin and resistin levels were predictors for all-cause mortality independent of other risk factors in patients with acute MI. These results confirmed and extended the positive correlations between these adipokines and mortality to a population consisting exclusively of MI.",
author = "Lee, {Sang Hak} and Ha, {Jong Won} and Kim, {Jung Sun} and Choi, {Eui Young} and Sungha Park and Kang, {Seok Min} and Donghoon Choi and Yangsoo Jang and Namsik Chung",
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Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction : Data from infarction prognosis study registry. / Lee, Sang Hak; Ha, Jong Won; Kim, Jung Sun; Choi, Eui Young; Park, Sungha; Kang, Seok Min; Choi, Donghoon; Jang, Yangsoo; Chung, Namsik.

In: Coronary artery disease, Vol. 20, No. 1, 01.01.2009, p. 33-39.

Research output: Contribution to journalArticle

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T1 - Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction

T2 - Data from infarction prognosis study registry

AU - Lee, Sang Hak

AU - Ha, Jong Won

AU - Kim, Jung Sun

AU - Choi, Eui Young

AU - Park, Sungha

AU - Kang, Seok Min

AU - Choi, Donghoon

AU - Jang, Yangsoo

AU - Chung, Namsik

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N2 - Background: Adiponectin and resistin, which have counteracting effects, are suggested to be associated with inflammation and atherosclerosis. The relationship between their levels and prognosis in high risk patients is, however, still unclear. The aim of this study was to evaluate the prognostic values of these adipokines in patients with acute myocardial infarction (MI). Methods: Adiponectin and resistin levels were measured at acute phase of MI in 397 consecutive patients. All patients were followed-up for the occurrence of all-cause and cardiovascular mortalities. Predictors for all-cause and cardiovascular mortalities were analyzed by Cox proportional hazard model. Results: During the mean follow-up period of 12 months, 28 (7.1%) patients died. Unadjusted all-cause mortality rate was significantly higher in patients with high tertiles of adiponectin (P = 0.002) and resistin (P = 0.002) levels. After controlling of clinical and laboratory variables, age [95% confidence interval (CI): 1.20-2.83, P = 0.006], adiponectin (95% CI: 1.01-1.22, P = 0.040), resistin (95% CI: 1.06-2.33, P = 0.025), and statin use (95% CI: 0.15-0.83, P = 0.017) were found to be independent predictors of all-cause mortality. For cardiovascular mortality, only age (95% CI: 1.33-3.25, P = 0.001) and renal insufficiency (95% CI: 1.52-12.22, P = 0.006) were independent predictors. Conclusion: High plasma adiponectin and resistin levels were predictors for all-cause mortality independent of other risk factors in patients with acute MI. These results confirmed and extended the positive correlations between these adipokines and mortality to a population consisting exclusively of MI.

AB - Background: Adiponectin and resistin, which have counteracting effects, are suggested to be associated with inflammation and atherosclerosis. The relationship between their levels and prognosis in high risk patients is, however, still unclear. The aim of this study was to evaluate the prognostic values of these adipokines in patients with acute myocardial infarction (MI). Methods: Adiponectin and resistin levels were measured at acute phase of MI in 397 consecutive patients. All patients were followed-up for the occurrence of all-cause and cardiovascular mortalities. Predictors for all-cause and cardiovascular mortalities were analyzed by Cox proportional hazard model. Results: During the mean follow-up period of 12 months, 28 (7.1%) patients died. Unadjusted all-cause mortality rate was significantly higher in patients with high tertiles of adiponectin (P = 0.002) and resistin (P = 0.002) levels. After controlling of clinical and laboratory variables, age [95% confidence interval (CI): 1.20-2.83, P = 0.006], adiponectin (95% CI: 1.01-1.22, P = 0.040), resistin (95% CI: 1.06-2.33, P = 0.025), and statin use (95% CI: 0.15-0.83, P = 0.017) were found to be independent predictors of all-cause mortality. For cardiovascular mortality, only age (95% CI: 1.33-3.25, P = 0.001) and renal insufficiency (95% CI: 1.52-12.22, P = 0.006) were independent predictors. Conclusion: High plasma adiponectin and resistin levels were predictors for all-cause mortality independent of other risk factors in patients with acute MI. These results confirmed and extended the positive correlations between these adipokines and mortality to a population consisting exclusively of MI.

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