Plasma carotenoids, retinol and tocopherol levels and the risk of ovarian cancer

Nan Hee Jeong, Eun Seop Song, Jong Min Lee, Kwang Beom Lee, Mi Kyung Kim, Ji Eun Cheon, Jae Kwan Lee, Sung Kyong Son, Jung Pil Lee, Jae-Hoon Kim, Soo Young Hur, Yong Il Kwon

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Abstract

Objective. We investigated the relation between plasma carotenoids, retinol and tocopherol levels and ovarian cancer risk in Korean women. Design. Hospital-based case-control study. Setting. Six tertiary medical institutes in Korea. Population. Forty-five epithelial ovarian cancers and 135 age-matched controls. Methods. Preoperative plasma concentrations of -carotene, lycopene, zeaxanthin plus lutein, retinol, -tocopherol, and -tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. Main outcome measures. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated by tertiles to evaluate the effect of micronutrients on endometrial cancer risk after adjustment for body mass (BMI) index, menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status. Results. Women in the highest tertile for -carotene had 0.12-times the risk of ovarian cancer of in the lowest tertile (OR 0.12; 95%CI 0.04-0.36). Women with the highest tertiles of lycopene (OR 0.09; 95%CI 0.03-0.32), zeaxanthin/lutein (OR 0.21; 95%CI 0.09-0.52), retinol (OR 0.45; 95%CI 0.21-0.98), -tocopherol (OR 0.23; 95%CI 0.10-0.53) and -tocopherol (OR 0.28; 95%CI 0.11-0.70) had lower risk of ovarian cancer than women in the lowest tertiles. Results were consistent across strata of socio-epidemiologic factors. Conclusions. Micronutrients, specifically ss-carotene, lycopene, zeaxanthin, lutein, retinol, -tocopherol, and -tocopherol, may play a role in reducing the risk of ovarian cancer.

Original languageEnglish
Pages (from-to)457-462
Number of pages6
JournalActa Obstetricia et Gynecologica Scandinavica
Volume88
Issue number4
DOIs
Publication statusPublished - 2009 Jul 30

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Tocopherols
Carotenoids
Vitamin A
Ovarian Neoplasms
Odds Ratio
Confidence Intervals
Lutein
Micronutrients
Epidemiologic Factors
Risk Adjustment
Endometrial Neoplasms
Korea
Oral Contraceptives
Menopause
Parity
Alcohol Drinking
Case-Control Studies
Body Mass Index
Smoking
High Pressure Liquid Chromatography

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Jeong, N. H., Song, E. S., Lee, J. M., Lee, K. B., Kim, M. K., Cheon, J. E., ... Kwon, Y. I. (2009). Plasma carotenoids, retinol and tocopherol levels and the risk of ovarian cancer. Acta Obstetricia et Gynecologica Scandinavica, 88(4), 457-462. https://doi.org/10.1080/00016340902807215
Jeong, Nan Hee ; Song, Eun Seop ; Lee, Jong Min ; Lee, Kwang Beom ; Kim, Mi Kyung ; Cheon, Ji Eun ; Lee, Jae Kwan ; Son, Sung Kyong ; Lee, Jung Pil ; Kim, Jae-Hoon ; Hur, Soo Young ; Kwon, Yong Il. / Plasma carotenoids, retinol and tocopherol levels and the risk of ovarian cancer. In: Acta Obstetricia et Gynecologica Scandinavica. 2009 ; Vol. 88, No. 4. pp. 457-462.
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abstract = "Objective. We investigated the relation between plasma carotenoids, retinol and tocopherol levels and ovarian cancer risk in Korean women. Design. Hospital-based case-control study. Setting. Six tertiary medical institutes in Korea. Population. Forty-five epithelial ovarian cancers and 135 age-matched controls. Methods. Preoperative plasma concentrations of -carotene, lycopene, zeaxanthin plus lutein, retinol, -tocopherol, and -tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. Main outcome measures. Odds ratios (OR) and 95{\%} confidence intervals (95{\%}CI) were estimated by tertiles to evaluate the effect of micronutrients on endometrial cancer risk after adjustment for body mass (BMI) index, menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status. Results. Women in the highest tertile for -carotene had 0.12-times the risk of ovarian cancer of in the lowest tertile (OR 0.12; 95{\%}CI 0.04-0.36). Women with the highest tertiles of lycopene (OR 0.09; 95{\%}CI 0.03-0.32), zeaxanthin/lutein (OR 0.21; 95{\%}CI 0.09-0.52), retinol (OR 0.45; 95{\%}CI 0.21-0.98), -tocopherol (OR 0.23; 95{\%}CI 0.10-0.53) and -tocopherol (OR 0.28; 95{\%}CI 0.11-0.70) had lower risk of ovarian cancer than women in the lowest tertiles. Results were consistent across strata of socio-epidemiologic factors. Conclusions. Micronutrients, specifically ss-carotene, lycopene, zeaxanthin, lutein, retinol, -tocopherol, and -tocopherol, may play a role in reducing the risk of ovarian cancer.",
author = "Jeong, {Nan Hee} and Song, {Eun Seop} and Lee, {Jong Min} and Lee, {Kwang Beom} and Kim, {Mi Kyung} and Cheon, {Ji Eun} and Lee, {Jae Kwan} and Son, {Sung Kyong} and Lee, {Jung Pil} and Jae-Hoon Kim and Hur, {Soo Young} and Kwon, {Yong Il}",
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Jeong, NH, Song, ES, Lee, JM, Lee, KB, Kim, MK, Cheon, JE, Lee, JK, Son, SK, Lee, JP, Kim, J-H, Hur, SY & Kwon, YI 2009, 'Plasma carotenoids, retinol and tocopherol levels and the risk of ovarian cancer', Acta Obstetricia et Gynecologica Scandinavica, vol. 88, no. 4, pp. 457-462. https://doi.org/10.1080/00016340902807215

Plasma carotenoids, retinol and tocopherol levels and the risk of ovarian cancer. / Jeong, Nan Hee; Song, Eun Seop; Lee, Jong Min; Lee, Kwang Beom; Kim, Mi Kyung; Cheon, Ji Eun; Lee, Jae Kwan; Son, Sung Kyong; Lee, Jung Pil; Kim, Jae-Hoon; Hur, Soo Young; Kwon, Yong Il.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 88, No. 4, 30.07.2009, p. 457-462.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Plasma carotenoids, retinol and tocopherol levels and the risk of ovarian cancer

AU - Jeong, Nan Hee

AU - Song, Eun Seop

AU - Lee, Jong Min

AU - Lee, Kwang Beom

AU - Kim, Mi Kyung

AU - Cheon, Ji Eun

AU - Lee, Jae Kwan

AU - Son, Sung Kyong

AU - Lee, Jung Pil

AU - Kim, Jae-Hoon

AU - Hur, Soo Young

AU - Kwon, Yong Il

PY - 2009/7/30

Y1 - 2009/7/30

N2 - Objective. We investigated the relation between plasma carotenoids, retinol and tocopherol levels and ovarian cancer risk in Korean women. Design. Hospital-based case-control study. Setting. Six tertiary medical institutes in Korea. Population. Forty-five epithelial ovarian cancers and 135 age-matched controls. Methods. Preoperative plasma concentrations of -carotene, lycopene, zeaxanthin plus lutein, retinol, -tocopherol, and -tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. Main outcome measures. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated by tertiles to evaluate the effect of micronutrients on endometrial cancer risk after adjustment for body mass (BMI) index, menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status. Results. Women in the highest tertile for -carotene had 0.12-times the risk of ovarian cancer of in the lowest tertile (OR 0.12; 95%CI 0.04-0.36). Women with the highest tertiles of lycopene (OR 0.09; 95%CI 0.03-0.32), zeaxanthin/lutein (OR 0.21; 95%CI 0.09-0.52), retinol (OR 0.45; 95%CI 0.21-0.98), -tocopherol (OR 0.23; 95%CI 0.10-0.53) and -tocopherol (OR 0.28; 95%CI 0.11-0.70) had lower risk of ovarian cancer than women in the lowest tertiles. Results were consistent across strata of socio-epidemiologic factors. Conclusions. Micronutrients, specifically ss-carotene, lycopene, zeaxanthin, lutein, retinol, -tocopherol, and -tocopherol, may play a role in reducing the risk of ovarian cancer.

AB - Objective. We investigated the relation between plasma carotenoids, retinol and tocopherol levels and ovarian cancer risk in Korean women. Design. Hospital-based case-control study. Setting. Six tertiary medical institutes in Korea. Population. Forty-five epithelial ovarian cancers and 135 age-matched controls. Methods. Preoperative plasma concentrations of -carotene, lycopene, zeaxanthin plus lutein, retinol, -tocopherol, and -tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. Main outcome measures. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated by tertiles to evaluate the effect of micronutrients on endometrial cancer risk after adjustment for body mass (BMI) index, menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status. Results. Women in the highest tertile for -carotene had 0.12-times the risk of ovarian cancer of in the lowest tertile (OR 0.12; 95%CI 0.04-0.36). Women with the highest tertiles of lycopene (OR 0.09; 95%CI 0.03-0.32), zeaxanthin/lutein (OR 0.21; 95%CI 0.09-0.52), retinol (OR 0.45; 95%CI 0.21-0.98), -tocopherol (OR 0.23; 95%CI 0.10-0.53) and -tocopherol (OR 0.28; 95%CI 0.11-0.70) had lower risk of ovarian cancer than women in the lowest tertiles. Results were consistent across strata of socio-epidemiologic factors. Conclusions. Micronutrients, specifically ss-carotene, lycopene, zeaxanthin, lutein, retinol, -tocopherol, and -tocopherol, may play a role in reducing the risk of ovarian cancer.

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