Plasma cell-free DNA as a predictive marker after radiotherapy for hepatocellular carcinoma

Sangjoon Park, Eun Jung Lee, Chai Hong Rim, Jinsil Seong

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Cell-free DNA (cfDNA) is gaining attention as a novel biomarker for oncologic outcomes. We investigated the clinical significance of cfDNA in hepatocellular carcinoma (HCC) patients treated with radiotherapy (RT). Materials and Methods: Fifty-five patients with HCC who received RT were recruited from two prospective study cohorts: one cohort of 34 patients who underwent conventionally fractionated RT and a second of 21 patients treated with stereotactic body radiation therapy. cfDNA was extracted and quantified. Results: In total, 30% of the patients had multiple tumors, 77% had tumors >2 cm, and 32% had portal vein tumor thrombus. Optimal cut-off values for cfDNA levels (33.65 ng/mL and 37.25 ng/mL, before and after RT) were used to divide patients into low-DNA (LDNA) and high-DNA (HDNA) groups. The pre-RT HDNA group tended to have more advanced disease and larger tumors (p=0.049 and p=0.017, respectively). Tumor response, intrahepatic failure-free rates, and local control (LC) rates were significantly better in the post-RT LDNA group (p=0.017, p=0.035, and p=0.006, respectively). Conclusion: Quantitative analysis of cfDNA was feasible in our cohorts. Post-RT cfDNA levels were negatively correlated with treatment outcomes, indicating the potential for the use of post-RT cfDNA levels as an early predictor of treatment responses and LC after RT for HCC patients.

Original languageEnglish
Pages (from-to)470-479
Number of pages10
JournalYonsei medical journal
Volume59
Issue number4
DOIs
Publication statusPublished - 2018 Jun

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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