Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women

Yumie Rhee, Man Jeong Paik, Kyoung Rae Kim, Young Guk Ko, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Sung Kil Lim

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: The present study examines changes in the pattern of plasma free polyunsaturated fatty acids (PUFA) according to menopausal status and the existence of diabetes mellitus (DM) or coronary heart disease (CHD) in Korean women. Methods: The participants were as follows; premenopausal women (PRE, n = 20) and postmenopausal women without any known chronic disease (POST, n = 35), with DM (DM, n = 35), or with angiographically proven CHD (CHD, n = 30). Plasma free fatty acids were measured in all participants. Results: Healthy premenopausal women had a higher ratio of ω-3/ω-6 PUFA than postmenopausal women (p = 0.001). As expected, the PRE group had higher docsapentaenoic acid (DPA) and docosahexaenoic acid (DHA) levels (p < 0.05) and lower arachidonic acid levels (p < 0.05) than the POST group. In turn, the healthy POST group had higher levels of DPA and DHA compared to the DM or CHD groups (p < 0.05). There were significant shifts of increased ω-6 and decreased ω-3 among the women, according to each disease. Conclusions: There was a significant relationship between ω-3 and ω-6 PUFA profiles and risk for CHD in women. This metabolic profile of PUFA might be an important surrogate marker in postmenopausal women.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalClinica Chimica Acta
Volume392
Issue number1-2
DOIs
Publication statusPublished - 2008 Jun 1

Fingerprint

Nonesterified Fatty Acids
Plasmas
Medical problems
Unsaturated Fatty Acids
Coronary Disease
Diabetes Mellitus
Docosahexaenoic Acids
Acids
Metabolome
Arachidonic Acid
Chronic Disease
Biomarkers

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Rhee, Yumie ; Paik, Man Jeong ; Kim, Kyoung Rae ; Ko, Young Guk ; Kang, Eun Seok ; Cha, Bong Soo ; Lee, Hyun Chul ; Lim, Sung Kil. / Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women. In: Clinica Chimica Acta. 2008 ; Vol. 392, No. 1-2. pp. 11-16.
@article{0593dbbcba3746918cbdfaf3b1c7dd6d,
title = "Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women",
abstract = "Background: The present study examines changes in the pattern of plasma free polyunsaturated fatty acids (PUFA) according to menopausal status and the existence of diabetes mellitus (DM) or coronary heart disease (CHD) in Korean women. Methods: The participants were as follows; premenopausal women (PRE, n = 20) and postmenopausal women without any known chronic disease (POST, n = 35), with DM (DM, n = 35), or with angiographically proven CHD (CHD, n = 30). Plasma free fatty acids were measured in all participants. Results: Healthy premenopausal women had a higher ratio of ω-3/ω-6 PUFA than postmenopausal women (p = 0.001). As expected, the PRE group had higher docsapentaenoic acid (DPA) and docosahexaenoic acid (DHA) levels (p < 0.05) and lower arachidonic acid levels (p < 0.05) than the POST group. In turn, the healthy POST group had higher levels of DPA and DHA compared to the DM or CHD groups (p < 0.05). There were significant shifts of increased ω-6 and decreased ω-3 among the women, according to each disease. Conclusions: There was a significant relationship between ω-3 and ω-6 PUFA profiles and risk for CHD in women. This metabolic profile of PUFA might be an important surrogate marker in postmenopausal women.",
author = "Yumie Rhee and Paik, {Man Jeong} and Kim, {Kyoung Rae} and Ko, {Young Guk} and Kang, {Eun Seok} and Cha, {Bong Soo} and Lee, {Hyun Chul} and Lim, {Sung Kil}",
year = "2008",
month = "6",
day = "1",
doi = "10.1016/j.cca.2008.02.012",
language = "English",
volume = "392",
pages = "11--16",
journal = "Clinica Chimica Acta",
issn = "0009-8981",
publisher = "Elsevier",
number = "1-2",

}

Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women. / Rhee, Yumie; Paik, Man Jeong; Kim, Kyoung Rae; Ko, Young Guk; Kang, Eun Seok; Cha, Bong Soo; Lee, Hyun Chul; Lim, Sung Kil.

In: Clinica Chimica Acta, Vol. 392, No. 1-2, 01.06.2008, p. 11-16.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women

AU - Rhee, Yumie

AU - Paik, Man Jeong

AU - Kim, Kyoung Rae

AU - Ko, Young Guk

AU - Kang, Eun Seok

AU - Cha, Bong Soo

AU - Lee, Hyun Chul

AU - Lim, Sung Kil

PY - 2008/6/1

Y1 - 2008/6/1

N2 - Background: The present study examines changes in the pattern of plasma free polyunsaturated fatty acids (PUFA) according to menopausal status and the existence of diabetes mellitus (DM) or coronary heart disease (CHD) in Korean women. Methods: The participants were as follows; premenopausal women (PRE, n = 20) and postmenopausal women without any known chronic disease (POST, n = 35), with DM (DM, n = 35), or with angiographically proven CHD (CHD, n = 30). Plasma free fatty acids were measured in all participants. Results: Healthy premenopausal women had a higher ratio of ω-3/ω-6 PUFA than postmenopausal women (p = 0.001). As expected, the PRE group had higher docsapentaenoic acid (DPA) and docosahexaenoic acid (DHA) levels (p < 0.05) and lower arachidonic acid levels (p < 0.05) than the POST group. In turn, the healthy POST group had higher levels of DPA and DHA compared to the DM or CHD groups (p < 0.05). There were significant shifts of increased ω-6 and decreased ω-3 among the women, according to each disease. Conclusions: There was a significant relationship between ω-3 and ω-6 PUFA profiles and risk for CHD in women. This metabolic profile of PUFA might be an important surrogate marker in postmenopausal women.

AB - Background: The present study examines changes in the pattern of plasma free polyunsaturated fatty acids (PUFA) according to menopausal status and the existence of diabetes mellitus (DM) or coronary heart disease (CHD) in Korean women. Methods: The participants were as follows; premenopausal women (PRE, n = 20) and postmenopausal women without any known chronic disease (POST, n = 35), with DM (DM, n = 35), or with angiographically proven CHD (CHD, n = 30). Plasma free fatty acids were measured in all participants. Results: Healthy premenopausal women had a higher ratio of ω-3/ω-6 PUFA than postmenopausal women (p = 0.001). As expected, the PRE group had higher docsapentaenoic acid (DPA) and docosahexaenoic acid (DHA) levels (p < 0.05) and lower arachidonic acid levels (p < 0.05) than the POST group. In turn, the healthy POST group had higher levels of DPA and DHA compared to the DM or CHD groups (p < 0.05). There were significant shifts of increased ω-6 and decreased ω-3 among the women, according to each disease. Conclusions: There was a significant relationship between ω-3 and ω-6 PUFA profiles and risk for CHD in women. This metabolic profile of PUFA might be an important surrogate marker in postmenopausal women.

UR - http://www.scopus.com/inward/record.url?scp=42749092248&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42749092248&partnerID=8YFLogxK

U2 - 10.1016/j.cca.2008.02.012

DO - 10.1016/j.cca.2008.02.012

M3 - Article

C2 - 18328818

AN - SCOPUS:42749092248

VL - 392

SP - 11

EP - 16

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

IS - 1-2

ER -