Plasma granulocyte elastase levels and its relation to D-dimer in liver cirrhosis

K. S. Song, H. K. Kim, Hyonsuk Kim, J. W. Song

Research output: Contribution to journalArticle

Abstract

Abnormalities of the fibrinolytic system in patients with liver disease have been known to exist and increased fibrinogen-fibrin degradation product(FDP) or D-dimer levels were reported in previous clinical studies. However, controversy exists as to whether the observed fibrinolysis is primary or a reflection of disseminated intravascular coagulation (DIG). Recently, granulocyte elastase has been shown to provide an alternative fibrinolytic pathway, also capable of degrading both fibrin and fibrinogen. We investigated plasma granulocyte elastase levels in 65 patients with liver cirrhosis and related it to D-dimer levels determined by enzyme linked immunoassay. Granulocyte elastase was carried out by heterogenous enzyme immunoassay using polymorphonuclear (PMN) Elastase kit (Diagnostica Merck, Darmstadt, Germany). The mean plasma levels of elastase (175.4jig/I) and D-dimer (2732.7 ng/ml) were significantly increased in patients with cirrhosis as compared to levels of normal subjects (elastase: 22 jjg/1; D-dimer: 276 ng/ml). There was significant difference of elastase levels among Child classes (P = 0.010) and etiology of cirrhosis (P = 0.007). D-dimer levels were significantly different among different Child groups (P = 0.020). Plasma elastase level was positively correlated with D-dimer level (r = 0.437, P< 0.001). We have demonstrated a marked increase of PMN elastase and its relation to plasma D-dimer levels in patients with cirrhosis. This findings suggest that accelerated fibrinolysis in cirrhosis may be associated with cellular neutrophil activation and elevated PMN elastase level may be an alternative cause of elevated D-dimer in cirrhosis.

Original languageEnglish
Number of pages1
JournalFibrinolysis and Proteolysis
Volume14
DOIs
Publication statusPublished - 2000 Jan 1

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Leukocyte Elastase
Pancreatic Elastase
Liver Cirrhosis
Fibrosis
Fibrinolysis
Immunoenzyme Techniques
Fibrin Fibrinogen Degradation Products
Neutrophil Activation
fibrin fragment D
Disseminated Intravascular Coagulation
Fibrin
Fibrinogen
Germany
Liver Diseases

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

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title = "Plasma granulocyte elastase levels and its relation to D-dimer in liver cirrhosis",
abstract = "Abnormalities of the fibrinolytic system in patients with liver disease have been known to exist and increased fibrinogen-fibrin degradation product(FDP) or D-dimer levels were reported in previous clinical studies. However, controversy exists as to whether the observed fibrinolysis is primary or a reflection of disseminated intravascular coagulation (DIG). Recently, granulocyte elastase has been shown to provide an alternative fibrinolytic pathway, also capable of degrading both fibrin and fibrinogen. We investigated plasma granulocyte elastase levels in 65 patients with liver cirrhosis and related it to D-dimer levels determined by enzyme linked immunoassay. Granulocyte elastase was carried out by heterogenous enzyme immunoassay using polymorphonuclear (PMN) Elastase kit (Diagnostica Merck, Darmstadt, Germany). The mean plasma levels of elastase (175.4jig/I) and D-dimer (2732.7 ng/ml) were significantly increased in patients with cirrhosis as compared to levels of normal subjects (elastase: 22 jjg/1; D-dimer: 276 ng/ml). There was significant difference of elastase levels among Child classes (P = 0.010) and etiology of cirrhosis (P = 0.007). D-dimer levels were significantly different among different Child groups (P = 0.020). Plasma elastase level was positively correlated with D-dimer level (r = 0.437, P< 0.001). We have demonstrated a marked increase of PMN elastase and its relation to plasma D-dimer levels in patients with cirrhosis. This findings suggest that accelerated fibrinolysis in cirrhosis may be associated with cellular neutrophil activation and elevated PMN elastase level may be an alternative cause of elevated D-dimer in cirrhosis.",
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Plasma granulocyte elastase levels and its relation to D-dimer in liver cirrhosis. / Song, K. S.; Kim, H. K.; Kim, Hyonsuk; Song, J. W.

In: Fibrinolysis and Proteolysis, Vol. 14, 01.01.2000.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Plasma granulocyte elastase levels and its relation to D-dimer in liver cirrhosis

AU - Song, K. S.

AU - Kim, H. K.

AU - Kim, Hyonsuk

AU - Song, J. W.

PY - 2000/1/1

Y1 - 2000/1/1

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AB - Abnormalities of the fibrinolytic system in patients with liver disease have been known to exist and increased fibrinogen-fibrin degradation product(FDP) or D-dimer levels were reported in previous clinical studies. However, controversy exists as to whether the observed fibrinolysis is primary or a reflection of disseminated intravascular coagulation (DIG). Recently, granulocyte elastase has been shown to provide an alternative fibrinolytic pathway, also capable of degrading both fibrin and fibrinogen. We investigated plasma granulocyte elastase levels in 65 patients with liver cirrhosis and related it to D-dimer levels determined by enzyme linked immunoassay. Granulocyte elastase was carried out by heterogenous enzyme immunoassay using polymorphonuclear (PMN) Elastase kit (Diagnostica Merck, Darmstadt, Germany). The mean plasma levels of elastase (175.4jig/I) and D-dimer (2732.7 ng/ml) were significantly increased in patients with cirrhosis as compared to levels of normal subjects (elastase: 22 jjg/1; D-dimer: 276 ng/ml). There was significant difference of elastase levels among Child classes (P = 0.010) and etiology of cirrhosis (P = 0.007). D-dimer levels were significantly different among different Child groups (P = 0.020). Plasma elastase level was positively correlated with D-dimer level (r = 0.437, P< 0.001). We have demonstrated a marked increase of PMN elastase and its relation to plasma D-dimer levels in patients with cirrhosis. This findings suggest that accelerated fibrinolysis in cirrhosis may be associated with cellular neutrophil activation and elevated PMN elastase level may be an alternative cause of elevated D-dimer in cirrhosis.

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