Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and proinflammatory ligand for RAGE (EN-RAGE) are associated with carotid atherosclerosis in patients with peritoneal dialysis

Jwa Kyung Kim, Sungha Park, Mi Jung Lee, Young Rim Song, Seung Hyeok Han, Sung Gyun Kim, Shin Wook Kang, Kyu Hun Choi, Hyung Jik Kim, Tae Hyun Yoo

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Objectives: The soluble receptor for advanced glycation end products (sRAGE) exerts a protective effect on the development of atherosclerotic vascular complications by inhibiting RAGE-mediated inflammatory response. In contrast, extracellular newly identified RAGE-binding protein (EN-RAGE) contributes to increased atherosclerosis as a pro-inflammatory ligand for RAGE. We determined the levels of sRAGE and EN-RAGE in peritoneal dialysis (PD) patients and evaluated their relationship with carotid atherosclerosis. Methods: A cross-sectional study was performed in 91 PD patients and 29 control subjects. Carotid IMT (cIMT) and abdominal aortic vascular calcification score (VCS) were evaluated using high-resolution B-mode ultrasonography and plain radiographic film of the lateral abdomen. Results: Plasma sRAGE and EN-RAGE levels were more than twice as higher in PD patients compared to controls. EN-RAGE showed a strong positive correlation with serum high-sensitivity CRP (p= 0.007) and IL-6 (p= 0.002), whereas sRAGE was negatively associated with those inflammatory markers (p= 0.001, p= 0.031). Even after adjustments for traditional cardiovascular risk factors, both sRAGE and EN-RAGE were independently associated with cIMT (β= -0.230, p= 0.037, β= 0.155, p= 0.045) and VCS (β= -0.205, p= 0.049, β= 0.197, p= 0.156). Multivariate logistic analysis revealed that old age (OR 1.14, 95% CI 1.03-1.25, p= 0.009), presence of diabetes (OR 13.4, 95% CI: 1.20-150.18, p= 0.035) and elevated plasma EN-RAGE (OR 2.26, 95% CI.: 1.05-5.11, p= 0.048) were significant predictors for the occurrence of carotid atherosclerosis (cIMT > 1.0. mm and/or plaque formation). Conclusions: Our findings suggest that elevated plasma EN-RAGE and decreased sRAGE level could play a crucial role in systemic inflammation and carotid atherosclerosis in PD patients.

Original languageEnglish
Pages (from-to)208-214
Number of pages7
JournalAtherosclerosis
Volume220
Issue number1
DOIs
Publication statusPublished - 2012 Jan

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and proinflammatory ligand for RAGE (EN-RAGE) are associated with carotid atherosclerosis in patients with peritoneal dialysis'. Together they form a unique fingerprint.

  • Cite this