Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and proinflammatory ligand for RAGE (EN-RAGE) are associated with carotid atherosclerosis in patients with peritoneal dialysis

Jwa Kyung Kim, Sungha Park, Mi Jung Lee, Young Rim Song, Seung Hyeok Han, Sung Gyun Kim, Shin Wook Kang, Kyu Hun Choi, Hyung Jik Kim, Tae Hyun Yoo

Research output: Contribution to journalArticle

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Abstract

Objectives: The soluble receptor for advanced glycation end products (sRAGE) exerts a protective effect on the development of atherosclerotic vascular complications by inhibiting RAGE-mediated inflammatory response. In contrast, extracellular newly identified RAGE-binding protein (EN-RAGE) contributes to increased atherosclerosis as a pro-inflammatory ligand for RAGE. We determined the levels of sRAGE and EN-RAGE in peritoneal dialysis (PD) patients and evaluated their relationship with carotid atherosclerosis. Methods: A cross-sectional study was performed in 91 PD patients and 29 control subjects. Carotid IMT (cIMT) and abdominal aortic vascular calcification score (VCS) were evaluated using high-resolution B-mode ultrasonography and plain radiographic film of the lateral abdomen. Results: Plasma sRAGE and EN-RAGE levels were more than twice as higher in PD patients compared to controls. EN-RAGE showed a strong positive correlation with serum high-sensitivity CRP (p= 0.007) and IL-6 (p= 0.002), whereas sRAGE was negatively associated with those inflammatory markers (p= 0.001, p= 0.031). Even after adjustments for traditional cardiovascular risk factors, both sRAGE and EN-RAGE were independently associated with cIMT (β= -0.230, p= 0.037, β= 0.155, p= 0.045) and VCS (β= -0.205, p= 0.049, β= 0.197, p= 0.156). Multivariate logistic analysis revealed that old age (OR 1.14, 95% CI 1.03-1.25, p= 0.009), presence of diabetes (OR 13.4, 95% CI: 1.20-150.18, p= 0.035) and elevated plasma EN-RAGE (OR 2.26, 95% CI.: 1.05-5.11, p= 0.048) were significant predictors for the occurrence of carotid atherosclerosis (cIMT > 1.0. mm and/or plaque formation). Conclusions: Our findings suggest that elevated plasma EN-RAGE and decreased sRAGE level could play a crucial role in systemic inflammation and carotid atherosclerosis in PD patients.

Original languageEnglish
Pages (from-to)208-214
Number of pages7
JournalAtherosclerosis
Volume220
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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Carotid Artery Diseases
Peritoneal Dialysis
Ligands
Vascular Calcification
X-Ray Film
Abdomen
Blood Vessels
Advanced Glycosylation End Product-Specific Receptor
Interleukin-6
Ultrasonography
Atherosclerosis
Carrier Proteins
Multivariate Analysis
Cross-Sectional Studies
Inflammation
Serum

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{878a4beb2bb0475cad64dc0eee37fb2f,
title = "Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and proinflammatory ligand for RAGE (EN-RAGE) are associated with carotid atherosclerosis in patients with peritoneal dialysis",
abstract = "Objectives: The soluble receptor for advanced glycation end products (sRAGE) exerts a protective effect on the development of atherosclerotic vascular complications by inhibiting RAGE-mediated inflammatory response. In contrast, extracellular newly identified RAGE-binding protein (EN-RAGE) contributes to increased atherosclerosis as a pro-inflammatory ligand for RAGE. We determined the levels of sRAGE and EN-RAGE in peritoneal dialysis (PD) patients and evaluated their relationship with carotid atherosclerosis. Methods: A cross-sectional study was performed in 91 PD patients and 29 control subjects. Carotid IMT (cIMT) and abdominal aortic vascular calcification score (VCS) were evaluated using high-resolution B-mode ultrasonography and plain radiographic film of the lateral abdomen. Results: Plasma sRAGE and EN-RAGE levels were more than twice as higher in PD patients compared to controls. EN-RAGE showed a strong positive correlation with serum high-sensitivity CRP (p= 0.007) and IL-6 (p= 0.002), whereas sRAGE was negatively associated with those inflammatory markers (p= 0.001, p= 0.031). Even after adjustments for traditional cardiovascular risk factors, both sRAGE and EN-RAGE were independently associated with cIMT (β= -0.230, p= 0.037, β= 0.155, p= 0.045) and VCS (β= -0.205, p= 0.049, β= 0.197, p= 0.156). Multivariate logistic analysis revealed that old age (OR 1.14, 95{\%} CI 1.03-1.25, p= 0.009), presence of diabetes (OR 13.4, 95{\%} CI: 1.20-150.18, p= 0.035) and elevated plasma EN-RAGE (OR 2.26, 95{\%} CI.: 1.05-5.11, p= 0.048) were significant predictors for the occurrence of carotid atherosclerosis (cIMT > 1.0. mm and/or plaque formation). Conclusions: Our findings suggest that elevated plasma EN-RAGE and decreased sRAGE level could play a crucial role in systemic inflammation and carotid atherosclerosis in PD patients.",
author = "Kim, {Jwa Kyung} and Sungha Park and Lee, {Mi Jung} and Song, {Young Rim} and Han, {Seung Hyeok} and Kim, {Sung Gyun} and Kang, {Shin Wook} and Choi, {Kyu Hun} and Kim, {Hyung Jik} and Yoo, {Tae Hyun}",
year = "2012",
month = "1",
day = "1",
doi = "10.1016/j.atherosclerosis.2011.07.115",
language = "English",
volume = "220",
pages = "208--214",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
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}

Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and proinflammatory ligand for RAGE (EN-RAGE) are associated with carotid atherosclerosis in patients with peritoneal dialysis. / Kim, Jwa Kyung; Park, Sungha; Lee, Mi Jung; Song, Young Rim; Han, Seung Hyeok; Kim, Sung Gyun; Kang, Shin Wook; Choi, Kyu Hun; Kim, Hyung Jik; Yoo, Tae Hyun.

In: Atherosclerosis, Vol. 220, No. 1, 01.01.2012, p. 208-214.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and proinflammatory ligand for RAGE (EN-RAGE) are associated with carotid atherosclerosis in patients with peritoneal dialysis

AU - Kim, Jwa Kyung

AU - Park, Sungha

AU - Lee, Mi Jung

AU - Song, Young Rim

AU - Han, Seung Hyeok

AU - Kim, Sung Gyun

AU - Kang, Shin Wook

AU - Choi, Kyu Hun

AU - Kim, Hyung Jik

AU - Yoo, Tae Hyun

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Objectives: The soluble receptor for advanced glycation end products (sRAGE) exerts a protective effect on the development of atherosclerotic vascular complications by inhibiting RAGE-mediated inflammatory response. In contrast, extracellular newly identified RAGE-binding protein (EN-RAGE) contributes to increased atherosclerosis as a pro-inflammatory ligand for RAGE. We determined the levels of sRAGE and EN-RAGE in peritoneal dialysis (PD) patients and evaluated their relationship with carotid atherosclerosis. Methods: A cross-sectional study was performed in 91 PD patients and 29 control subjects. Carotid IMT (cIMT) and abdominal aortic vascular calcification score (VCS) were evaluated using high-resolution B-mode ultrasonography and plain radiographic film of the lateral abdomen. Results: Plasma sRAGE and EN-RAGE levels were more than twice as higher in PD patients compared to controls. EN-RAGE showed a strong positive correlation with serum high-sensitivity CRP (p= 0.007) and IL-6 (p= 0.002), whereas sRAGE was negatively associated with those inflammatory markers (p= 0.001, p= 0.031). Even after adjustments for traditional cardiovascular risk factors, both sRAGE and EN-RAGE were independently associated with cIMT (β= -0.230, p= 0.037, β= 0.155, p= 0.045) and VCS (β= -0.205, p= 0.049, β= 0.197, p= 0.156). Multivariate logistic analysis revealed that old age (OR 1.14, 95% CI 1.03-1.25, p= 0.009), presence of diabetes (OR 13.4, 95% CI: 1.20-150.18, p= 0.035) and elevated plasma EN-RAGE (OR 2.26, 95% CI.: 1.05-5.11, p= 0.048) were significant predictors for the occurrence of carotid atherosclerosis (cIMT > 1.0. mm and/or plaque formation). Conclusions: Our findings suggest that elevated plasma EN-RAGE and decreased sRAGE level could play a crucial role in systemic inflammation and carotid atherosclerosis in PD patients.

AB - Objectives: The soluble receptor for advanced glycation end products (sRAGE) exerts a protective effect on the development of atherosclerotic vascular complications by inhibiting RAGE-mediated inflammatory response. In contrast, extracellular newly identified RAGE-binding protein (EN-RAGE) contributes to increased atherosclerosis as a pro-inflammatory ligand for RAGE. We determined the levels of sRAGE and EN-RAGE in peritoneal dialysis (PD) patients and evaluated their relationship with carotid atherosclerosis. Methods: A cross-sectional study was performed in 91 PD patients and 29 control subjects. Carotid IMT (cIMT) and abdominal aortic vascular calcification score (VCS) were evaluated using high-resolution B-mode ultrasonography and plain radiographic film of the lateral abdomen. Results: Plasma sRAGE and EN-RAGE levels were more than twice as higher in PD patients compared to controls. EN-RAGE showed a strong positive correlation with serum high-sensitivity CRP (p= 0.007) and IL-6 (p= 0.002), whereas sRAGE was negatively associated with those inflammatory markers (p= 0.001, p= 0.031). Even after adjustments for traditional cardiovascular risk factors, both sRAGE and EN-RAGE were independently associated with cIMT (β= -0.230, p= 0.037, β= 0.155, p= 0.045) and VCS (β= -0.205, p= 0.049, β= 0.197, p= 0.156). Multivariate logistic analysis revealed that old age (OR 1.14, 95% CI 1.03-1.25, p= 0.009), presence of diabetes (OR 13.4, 95% CI: 1.20-150.18, p= 0.035) and elevated plasma EN-RAGE (OR 2.26, 95% CI.: 1.05-5.11, p= 0.048) were significant predictors for the occurrence of carotid atherosclerosis (cIMT > 1.0. mm and/or plaque formation). Conclusions: Our findings suggest that elevated plasma EN-RAGE and decreased sRAGE level could play a crucial role in systemic inflammation and carotid atherosclerosis in PD patients.

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U2 - 10.1016/j.atherosclerosis.2011.07.115

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VL - 220

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JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

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