Plasma Neutrophil Gelatinase-associated Lipoprotein in Living Kidney Donors

Y. E. Yoon, Y. I. Cho, S. Y. Kim, H. H. Lee, K. H. Huh, YuSeun Kim, WoongKyu Han

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker for acute kidney injury. This study was conducted to determine the clinical implications of perioperative plasma NGAL levels for renal function after living donor nephrectomy. Methods Between July 2013 and May 2014, 112 donors underwent live donor nephrectomy at our institution. Donor plasma NGAL levels were measured perioperatively for 6 months. The relationship between perioperative plasma NGAL and recovery of renal function was analyzed. Renal function was estimated with the Modification of Diet in Renal Disease formula. Results Mean preoperative NGAL was 62.1 ± 29.5 ng/mL. Plasma NGAL was most elevated 1 week postoperatively (218 ± 95.5 ng/mL), and stabilized after 1 month (122.9 ± 45.3 ng/mL). Preoperative plasma NGAL was not correlated with donor age or preoperative estimated glomerular filtration rates (eGFR), but was negatively correlated with 6-month eGFR (r = -0.458, P <.001). During the observation period, plasma NGAL at 1 week was most correlated with 6-month eGFR (r = -0.554, P <.001). An ROC curve analysis showed that age, preoperative eGFR, and 1-week postoperative plasma NGAL were highly predictive of developing of chronic kidney disease (CKD), defined as eGFR <60 mL/min/1.73 m2, 6 months postoperatively (AUC = 0.91, P <.001). One-week postoperative plasma NGAL was also independently associated with CKD risk at 6 months (odds ratio: 1.13 for each 10 ng/mL increase, P =.013). Conclusion Plasma NGAL becomes elevated after kidney donation and can provide information about acute kidney injury during the compensatory hyperfiltration period. Donors with increased perioperative plasma NGAL require close observation because their possibility of developing CKD after donation may be greater.

Original languageEnglish
Pages (from-to)738-741
Number of pages4
JournalTransplantation Proceedings
Volume48
Issue number3
DOIs
Publication statusPublished - 2016 Apr 1

Fingerprint

Gelatinases
Living Donors
Lipoproteins
Neutrophils
Kidney
Glomerular Filtration Rate
Chronic Renal Insufficiency
Tissue Donors
Nephrectomy
Acute Kidney Injury
ROC Curve
Lipocalin-2
Lipocalin 1
Observation
Diet Therapy
Recovery of Function
Area Under Curve
Biomarkers

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Yoon, Y. E. ; Cho, Y. I. ; Kim, S. Y. ; Lee, H. H. ; Huh, K. H. ; Kim, YuSeun ; Han, WoongKyu. / Plasma Neutrophil Gelatinase-associated Lipoprotein in Living Kidney Donors. In: Transplantation Proceedings. 2016 ; Vol. 48, No. 3. pp. 738-741.
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abstract = "Background Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker for acute kidney injury. This study was conducted to determine the clinical implications of perioperative plasma NGAL levels for renal function after living donor nephrectomy. Methods Between July 2013 and May 2014, 112 donors underwent live donor nephrectomy at our institution. Donor plasma NGAL levels were measured perioperatively for 6 months. The relationship between perioperative plasma NGAL and recovery of renal function was analyzed. Renal function was estimated with the Modification of Diet in Renal Disease formula. Results Mean preoperative NGAL was 62.1 ± 29.5 ng/mL. Plasma NGAL was most elevated 1 week postoperatively (218 ± 95.5 ng/mL), and stabilized after 1 month (122.9 ± 45.3 ng/mL). Preoperative plasma NGAL was not correlated with donor age or preoperative estimated glomerular filtration rates (eGFR), but was negatively correlated with 6-month eGFR (r = -0.458, P <.001). During the observation period, plasma NGAL at 1 week was most correlated with 6-month eGFR (r = -0.554, P <.001). An ROC curve analysis showed that age, preoperative eGFR, and 1-week postoperative plasma NGAL were highly predictive of developing of chronic kidney disease (CKD), defined as eGFR <60 mL/min/1.73 m2, 6 months postoperatively (AUC = 0.91, P <.001). One-week postoperative plasma NGAL was also independently associated with CKD risk at 6 months (odds ratio: 1.13 for each 10 ng/mL increase, P =.013). Conclusion Plasma NGAL becomes elevated after kidney donation and can provide information about acute kidney injury during the compensatory hyperfiltration period. Donors with increased perioperative plasma NGAL require close observation because their possibility of developing CKD after donation may be greater.",
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Plasma Neutrophil Gelatinase-associated Lipoprotein in Living Kidney Donors. / Yoon, Y. E.; Cho, Y. I.; Kim, S. Y.; Lee, H. H.; Huh, K. H.; Kim, YuSeun; Han, WoongKyu.

In: Transplantation Proceedings, Vol. 48, No. 3, 01.04.2016, p. 738-741.

Research output: Contribution to journalArticle

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T1 - Plasma Neutrophil Gelatinase-associated Lipoprotein in Living Kidney Donors

AU - Yoon, Y. E.

AU - Cho, Y. I.

AU - Kim, S. Y.

AU - Lee, H. H.

AU - Huh, K. H.

AU - Kim, YuSeun

AU - Han, WoongKyu

PY - 2016/4/1

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N2 - Background Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker for acute kidney injury. This study was conducted to determine the clinical implications of perioperative plasma NGAL levels for renal function after living donor nephrectomy. Methods Between July 2013 and May 2014, 112 donors underwent live donor nephrectomy at our institution. Donor plasma NGAL levels were measured perioperatively for 6 months. The relationship between perioperative plasma NGAL and recovery of renal function was analyzed. Renal function was estimated with the Modification of Diet in Renal Disease formula. Results Mean preoperative NGAL was 62.1 ± 29.5 ng/mL. Plasma NGAL was most elevated 1 week postoperatively (218 ± 95.5 ng/mL), and stabilized after 1 month (122.9 ± 45.3 ng/mL). Preoperative plasma NGAL was not correlated with donor age or preoperative estimated glomerular filtration rates (eGFR), but was negatively correlated with 6-month eGFR (r = -0.458, P <.001). During the observation period, plasma NGAL at 1 week was most correlated with 6-month eGFR (r = -0.554, P <.001). An ROC curve analysis showed that age, preoperative eGFR, and 1-week postoperative plasma NGAL were highly predictive of developing of chronic kidney disease (CKD), defined as eGFR <60 mL/min/1.73 m2, 6 months postoperatively (AUC = 0.91, P <.001). One-week postoperative plasma NGAL was also independently associated with CKD risk at 6 months (odds ratio: 1.13 for each 10 ng/mL increase, P =.013). Conclusion Plasma NGAL becomes elevated after kidney donation and can provide information about acute kidney injury during the compensatory hyperfiltration period. Donors with increased perioperative plasma NGAL require close observation because their possibility of developing CKD after donation may be greater.

AB - Background Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker for acute kidney injury. This study was conducted to determine the clinical implications of perioperative plasma NGAL levels for renal function after living donor nephrectomy. Methods Between July 2013 and May 2014, 112 donors underwent live donor nephrectomy at our institution. Donor plasma NGAL levels were measured perioperatively for 6 months. The relationship between perioperative plasma NGAL and recovery of renal function was analyzed. Renal function was estimated with the Modification of Diet in Renal Disease formula. Results Mean preoperative NGAL was 62.1 ± 29.5 ng/mL. Plasma NGAL was most elevated 1 week postoperatively (218 ± 95.5 ng/mL), and stabilized after 1 month (122.9 ± 45.3 ng/mL). Preoperative plasma NGAL was not correlated with donor age or preoperative estimated glomerular filtration rates (eGFR), but was negatively correlated with 6-month eGFR (r = -0.458, P <.001). During the observation period, plasma NGAL at 1 week was most correlated with 6-month eGFR (r = -0.554, P <.001). An ROC curve analysis showed that age, preoperative eGFR, and 1-week postoperative plasma NGAL were highly predictive of developing of chronic kidney disease (CKD), defined as eGFR <60 mL/min/1.73 m2, 6 months postoperatively (AUC = 0.91, P <.001). One-week postoperative plasma NGAL was also independently associated with CKD risk at 6 months (odds ratio: 1.13 for each 10 ng/mL increase, P =.013). Conclusion Plasma NGAL becomes elevated after kidney donation and can provide information about acute kidney injury during the compensatory hyperfiltration period. Donors with increased perioperative plasma NGAL require close observation because their possibility of developing CKD after donation may be greater.

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