Plasmid-encoded AmpC β-lactamases

How far have we gone 10 years after the discovery?

Adolf Bauernfeind, Yunsop Chong, Kyungwon Lee

Research output: Contribution to journalReview article

86 Citations (Scopus)

Abstract

The dogma that ampC genes are located exclusively on the chromosome was dominant until about 10 years ago. Since 1989 over 15 different plasmid- encoded AmpC β-lactamases have been reported from several countries. Most of these enzymes evolved in two clusters. The major cluster includes several enzymes with a high similarity to CMY-2, which is the closest related chromosomal AmpC enzyme of Citrobacter freundii. A second cluster centers around CMY-1. It is less homogeneous and not closely related chromosomal AmpC enzymes. Molecular diversification by amino acid substitutions does not usually translate into a change in the resistance phenotype. At this time, CMY-2 appears to be the most prevalent and widely distributed. Further global increase of prevalence and diversity of plasmidic AmpC β-lactamases have to be anticipated in the next millenium.

Original languageEnglish
Pages (from-to)520-525
Number of pages6
JournalYonsei Medical Journal
Volume39
Issue number6
DOIs
Publication statusPublished - 1998 Jan 1

Fingerprint

Plasmids
Enzymes
Citrobacter freundii
Amino Acid Substitution
Chromosomes
Phenotype
Genes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{5033888564304a2f9fc0ff40feec318f,
title = "Plasmid-encoded AmpC β-lactamases: How far have we gone 10 years after the discovery?",
abstract = "The dogma that ampC genes are located exclusively on the chromosome was dominant until about 10 years ago. Since 1989 over 15 different plasmid- encoded AmpC β-lactamases have been reported from several countries. Most of these enzymes evolved in two clusters. The major cluster includes several enzymes with a high similarity to CMY-2, which is the closest related chromosomal AmpC enzyme of Citrobacter freundii. A second cluster centers around CMY-1. It is less homogeneous and not closely related chromosomal AmpC enzymes. Molecular diversification by amino acid substitutions does not usually translate into a change in the resistance phenotype. At this time, CMY-2 appears to be the most prevalent and widely distributed. Further global increase of prevalence and diversity of plasmidic AmpC β-lactamases have to be anticipated in the next millenium.",
author = "Adolf Bauernfeind and Yunsop Chong and Kyungwon Lee",
year = "1998",
month = "1",
day = "1",
doi = "10.3349/ymj.1998.39.6.520",
language = "English",
volume = "39",
pages = "520--525",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "6",

}

Plasmid-encoded AmpC β-lactamases : How far have we gone 10 years after the discovery? / Bauernfeind, Adolf; Chong, Yunsop; Lee, Kyungwon.

In: Yonsei Medical Journal, Vol. 39, No. 6, 01.01.1998, p. 520-525.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Plasmid-encoded AmpC β-lactamases

T2 - How far have we gone 10 years after the discovery?

AU - Bauernfeind, Adolf

AU - Chong, Yunsop

AU - Lee, Kyungwon

PY - 1998/1/1

Y1 - 1998/1/1

N2 - The dogma that ampC genes are located exclusively on the chromosome was dominant until about 10 years ago. Since 1989 over 15 different plasmid- encoded AmpC β-lactamases have been reported from several countries. Most of these enzymes evolved in two clusters. The major cluster includes several enzymes with a high similarity to CMY-2, which is the closest related chromosomal AmpC enzyme of Citrobacter freundii. A second cluster centers around CMY-1. It is less homogeneous and not closely related chromosomal AmpC enzymes. Molecular diversification by amino acid substitutions does not usually translate into a change in the resistance phenotype. At this time, CMY-2 appears to be the most prevalent and widely distributed. Further global increase of prevalence and diversity of plasmidic AmpC β-lactamases have to be anticipated in the next millenium.

AB - The dogma that ampC genes are located exclusively on the chromosome was dominant until about 10 years ago. Since 1989 over 15 different plasmid- encoded AmpC β-lactamases have been reported from several countries. Most of these enzymes evolved in two clusters. The major cluster includes several enzymes with a high similarity to CMY-2, which is the closest related chromosomal AmpC enzyme of Citrobacter freundii. A second cluster centers around CMY-1. It is less homogeneous and not closely related chromosomal AmpC enzymes. Molecular diversification by amino acid substitutions does not usually translate into a change in the resistance phenotype. At this time, CMY-2 appears to be the most prevalent and widely distributed. Further global increase of prevalence and diversity of plasmidic AmpC β-lactamases have to be anticipated in the next millenium.

UR - http://www.scopus.com/inward/record.url?scp=0032450190&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032450190&partnerID=8YFLogxK

U2 - 10.3349/ymj.1998.39.6.520

DO - 10.3349/ymj.1998.39.6.520

M3 - Review article

VL - 39

SP - 520

EP - 525

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 6

ER -