Plasmid-encoded AmpC β-lactamases: How far have we gone 10 years after the discovery?

Adolf Bauernfeind, Yunsop Chong, Kyungwon Lee

Research output: Contribution to journalReview articlepeer-review

86 Citations (Scopus)

Abstract

The dogma that ampC genes are located exclusively on the chromosome was dominant until about 10 years ago. Since 1989 over 15 different plasmid- encoded AmpC β-lactamases have been reported from several countries. Most of these enzymes evolved in two clusters. The major cluster includes several enzymes with a high similarity to CMY-2, which is the closest related chromosomal AmpC enzyme of Citrobacter freundii. A second cluster centers around CMY-1. It is less homogeneous and not closely related chromosomal AmpC enzymes. Molecular diversification by amino acid substitutions does not usually translate into a change in the resistance phenotype. At this time, CMY-2 appears to be the most prevalent and widely distributed. Further global increase of prevalence and diversity of plasmidic AmpC β-lactamases have to be anticipated in the next millenium.

Original languageEnglish
Pages (from-to)520-525
Number of pages6
JournalYonsei medical journal
Volume39
Issue number6
DOIs
Publication statusPublished - 1998

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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