Aim: It has been proposed that platelet-rich fibrin (PRF) can be used to support bone regeneration during alveolar ridge augmentation. The aim of this study was to determine whether an approach utilizing PRF provides similar performance to the established guided bone regeneration (GBR) procedure. Materials and Methods: Two-wall defects were surgically created in beagle dogs and treated in three experimental groups: (i) a sticky bone (SB) substitute prepared using liquid PRF and deproteinized porcine bone mineral (DPBM); (ii) SB covered with solid PRF compressed into a membrane; and (iii) GBR performed using DPBM covered by a collagen membrane. Quantitative reverse-transcription polymerase chain reaction was applied to the specimen after 1 week of healing, and microcomputed tomography (micro-CT) and histological outcomes were analysed after 8 weeks of healing. Results: Compared with GBR, PRF resulted in a moderate increase in the expression levels of osteoblast and osteoclast markers, osteocalcin, and calcitonin receptor. Moreover, PRF modestly increased angiogenesis and the inflammation markers vascular endothelial growth factor (VEGF) and IL-6. Micro-CT and histological analyses confirmed the expected increased alveolar ridge area, with no significant differences between the three groups. Consistently, graft consolidation, as indicated by new bone formation at the defect site, did not differ significantly between groups. Conclusions: The present results demonstrate that PRF-based approaches perform comparably to the established GBR procedure in terms of the consolidation of DPBM in two-wall alveolar defects.
|Number of pages||10|
|Journal||Journal of Clinical Periodontology|
|Publication status||Published - 2023 Mar|
Bibliographical noteFunding Information:
This work was supported by the grant from the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT of the South Korean government (grant number NRF‐2022R1A2C2005537) and a grant from the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health and Welfare, and the Ministry of Food and Drug Safety of the South Korean government (grant number KMDF_PR_20200901_0238).
National Research Foundation of Korea; Ministry of Science and ICT of the South Korean government, Grant/Award Number: NRF‐2022R1A2C2005537; Ministry of Trade, Industry and Energy; Ministry of Health and Welfare; Ministry of Food and Drug Safety of the South Korean government, Grant/Award Number: KMDF_PR_20200901_0238 Funding information
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