Pleiotropic functions of fibroblast growth factor signaling in embryonic mammary gland development

Eun Jung Kim, Hansung Jung, Pengfei Lu

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in the fibroblast growth factor (FGF) signaling pathway, are co-opted for induction, maintenance and morphogenesis of the mammary glands. Understanding the mechanism whereby FGF signaling regulates the fundamental cell behavior during normal mammary gland develop may facilitate determination of the consequences of its deregulation during breast cancer progression.

Original languageEnglish
Pages (from-to)139-142
Number of pages4
JournalJournal of Mammary Gland Biology and Neoplasia
Volume18
Issue number2
DOIs
Publication statusPublished - 2013 Jun 1

Fingerprint

Fibroblast Growth Factors
Human Mammary Glands
Morphogenesis
Vertebrates
Mammals
Maintenance
Breast Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

@article{758ce6149a37414595e23b34b6ca416f,
title = "Pleiotropic functions of fibroblast growth factor signaling in embryonic mammary gland development",
abstract = "The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in the fibroblast growth factor (FGF) signaling pathway, are co-opted for induction, maintenance and morphogenesis of the mammary glands. Understanding the mechanism whereby FGF signaling regulates the fundamental cell behavior during normal mammary gland develop may facilitate determination of the consequences of its deregulation during breast cancer progression.",
author = "Kim, {Eun Jung} and Hansung Jung and Pengfei Lu",
year = "2013",
month = "6",
day = "1",
doi = "10.1007/s10911-013-9278-4",
language = "English",
volume = "18",
pages = "139--142",
journal = "Journal of Mammary Gland Biology and Neoplasia",
issn = "1083-3021",
publisher = "Springer New York",
number = "2",

}

Pleiotropic functions of fibroblast growth factor signaling in embryonic mammary gland development. / Kim, Eun Jung; Jung, Hansung; Lu, Pengfei.

In: Journal of Mammary Gland Biology and Neoplasia, Vol. 18, No. 2, 01.06.2013, p. 139-142.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Pleiotropic functions of fibroblast growth factor signaling in embryonic mammary gland development

AU - Kim, Eun Jung

AU - Jung, Hansung

AU - Lu, Pengfei

PY - 2013/6/1

Y1 - 2013/6/1

N2 - The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in the fibroblast growth factor (FGF) signaling pathway, are co-opted for induction, maintenance and morphogenesis of the mammary glands. Understanding the mechanism whereby FGF signaling regulates the fundamental cell behavior during normal mammary gland develop may facilitate determination of the consequences of its deregulation during breast cancer progression.

AB - The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in the fibroblast growth factor (FGF) signaling pathway, are co-opted for induction, maintenance and morphogenesis of the mammary glands. Understanding the mechanism whereby FGF signaling regulates the fundamental cell behavior during normal mammary gland develop may facilitate determination of the consequences of its deregulation during breast cancer progression.

UR - http://www.scopus.com/inward/record.url?scp=84879692135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879692135&partnerID=8YFLogxK

U2 - 10.1007/s10911-013-9278-4

DO - 10.1007/s10911-013-9278-4

M3 - Review article

VL - 18

SP - 139

EP - 142

JO - Journal of Mammary Gland Biology and Neoplasia

JF - Journal of Mammary Gland Biology and Neoplasia

SN - 1083-3021

IS - 2

ER -