Pleiotropic functions of fibroblast growth factor signaling in embryonic mammary gland development

Eun Jung Kim, Han Sung Jung, Pengfei Lu

Research output: Contribution to journalReview article

9 Citations (Scopus)


The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in the fibroblast growth factor (FGF) signaling pathway, are co-opted for induction, maintenance and morphogenesis of the mammary glands. Understanding the mechanism whereby FGF signaling regulates the fundamental cell behavior during normal mammary gland develop may facilitate determination of the consequences of its deregulation during breast cancer progression.

Original languageEnglish
Pages (from-to)139-142
Number of pages4
JournalJournal of Mammary Gland Biology and Neoplasia
Issue number2
Publication statusPublished - 2013 Jun 1


All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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