The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in the fibroblast growth factor (FGF) signaling pathway, are co-opted for induction, maintenance and morphogenesis of the mammary glands. Understanding the mechanism whereby FGF signaling regulates the fundamental cell behavior during normal mammary gland develop may facilitate determination of the consequences of its deregulation during breast cancer progression.
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Acknowledgements We would like to Ms. Hannah Collins for reading the manuscript. This work was supported by grants from the National Research Foundation of Korea (NRF) (No. 2011–0015661) to H.S.J. and from Breakthrough Breast Cancer to P.L. The Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, was supported by core funding from the Wellcome Trust (088785/Z/09/Z).
All Science Journal Classification (ASJC) codes
- Cancer Research