Plug-and-play safe-by-design production of metal-doped tellurium nanoparticles with safer antimicrobial activities

Dae Hoon Park, Milan Gautam, Sung Jae Park, Jungho Hwang, Chul Soon Yong, Jong Oh Kim, Jeong Hoon Byeon

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Safe-by-design principles, such as optimum balance of material function and safety, have received much recent attention. On-demand production is also receiving great interest in the realization of nanotechnologies that meet unpredictable demands of reconfiguration and modification to maximize the efficacy of materials processing. Antimicrobial nanomaterials are representative subjects of these approaches, because they require built-to-order configurations with safe-by-design principles for practical applications. However, few studies have achieved biosafety with original material function using economically feasible production platforms. In this regard, we developed a safe-by-design plug-and-play approach for continuous gas flow production of silver (or copper)-doped tellurium (Ag- or Cu-Te) nanoparticles with safer antimicrobial activity. Using this approach, we achieved precise modulation of dopant contents (5-8% atomic Ag and Cu) in nanoparticles without using batch hydrothermal chemistry. We also suggest the use of ratios between biocompatibility and antimicrobial activity as safety indices (SIs) for evaluations of nanoparticle applications. Approximately 6% atomic Ag in Ag-Te particles exhibited an optimal SI and significantly reduced the minimum inhibitory concentration of individual Te nanoparticles.

Original languageEnglish
Pages (from-to)2074-2083
Number of pages10
JournalEnvironmental Science: Nano
Volume6
Issue number7
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Tellurium
tellurium
antimicrobial activity
Metals
Nanoparticles
metal
safety
biosafety
Production platforms
nanotechnology
gas flow
Biocompatibility
Nanotechnology
Silver
Nanostructured materials
Flow of gases
Copper
silver
Doping (additives)
Modulation

All Science Journal Classification (ASJC) codes

  • Materials Science (miscellaneous)
  • Environmental Science(all)

Cite this

Park, Dae Hoon ; Gautam, Milan ; Park, Sung Jae ; Hwang, Jungho ; Yong, Chul Soon ; Kim, Jong Oh ; Byeon, Jeong Hoon. / Plug-and-play safe-by-design production of metal-doped tellurium nanoparticles with safer antimicrobial activities. In: Environmental Science: Nano. 2019 ; Vol. 6, No. 7. pp. 2074-2083.
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Plug-and-play safe-by-design production of metal-doped tellurium nanoparticles with safer antimicrobial activities. / Park, Dae Hoon; Gautam, Milan; Park, Sung Jae; Hwang, Jungho; Yong, Chul Soon; Kim, Jong Oh; Byeon, Jeong Hoon.

In: Environmental Science: Nano, Vol. 6, No. 7, 01.01.2019, p. 2074-2083.

Research output: Contribution to journalArticle

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