Plug-In Safe-by-Design Nanoinorganic Antibacterials

Milan Gautam, Dae Hoon Park, Sung Jae Park, Kang Sik Nam, Geun Young Park, Jungho Hwang, Chul Soon Yong, Jong Oh Kim, Jeong Hoon Byeon

Research output: Contribution to journalArticle

Abstract

Due to antimicrobial resistance and the adverse health effects that follow broad and inappropriate use of antibacterial agents, new classes of antibacterials with broad and strong bactericidal activity and safety for human use are urgently required globally, increasingly so with the onset of climate change. However, R&D in this field is known to be rarely profitable, unless a cost-effective, flexible, and convenient platform that ensures the production of workable candidate antibacterials can be developed. To address this issue, inorganic nanomaterials have been considered for their bactericidal activities, yet further investigations of composition crystalline modifications and/or surface biomaterial coatings are still required to provide effective and safe antibacterial nanoparticles. In this study, we developed a plug-in system comprising a spark plasma reactor and a flow heater under nitrogen gas flow to supply precursor inorganic nanoparticles (Cu-Te configuration) that can be modulated in-flight at different temperatures. From antibacterial and toxicological assays in both in vitro and in vivo models, bactericidal and toxicological profiles showed that the plug-in system-based platform can be used to identify key parameters for producing safe-by-design agents with antibacterial activity [>88% (in vitro) and >80% (in vivo) in antibacterial efficiency] and safety (>65% in in vitro viability and >60% in in vivo survival rate).

Original languageEnglish
Pages (from-to)12798-12809
Number of pages12
JournalACS Nano
Volume13
Issue number11
DOIs
Publication statusPublished - 2019 Nov 26

Fingerprint

plugs
Nanoparticles
Bactericides
safety
Biocompatible Materials
platforms
Electric sparks
Nanostructured materials
Biomaterials
Climate change
Flow of gases
Assays
nanoparticles
Nitrogen
Health
climate change
Anti-Bacterial Agents
Crystalline materials
sparks
Plasmas

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Gautam, M., Park, D. H., Park, S. J., Nam, K. S., Park, G. Y., Hwang, J., ... Byeon, J. H. (2019). Plug-In Safe-by-Design Nanoinorganic Antibacterials. ACS Nano, 13(11), 12798-12809. https://doi.org/10.1021/acsnano.9b04939
Gautam, Milan ; Park, Dae Hoon ; Park, Sung Jae ; Nam, Kang Sik ; Park, Geun Young ; Hwang, Jungho ; Yong, Chul Soon ; Kim, Jong Oh ; Byeon, Jeong Hoon. / Plug-In Safe-by-Design Nanoinorganic Antibacterials. In: ACS Nano. 2019 ; Vol. 13, No. 11. pp. 12798-12809.
@article{1a694b17b19f4e0ea013e2ff77be06ab,
title = "Plug-In Safe-by-Design Nanoinorganic Antibacterials",
abstract = "Due to antimicrobial resistance and the adverse health effects that follow broad and inappropriate use of antibacterial agents, new classes of antibacterials with broad and strong bactericidal activity and safety for human use are urgently required globally, increasingly so with the onset of climate change. However, R&D in this field is known to be rarely profitable, unless a cost-effective, flexible, and convenient platform that ensures the production of workable candidate antibacterials can be developed. To address this issue, inorganic nanomaterials have been considered for their bactericidal activities, yet further investigations of composition crystalline modifications and/or surface biomaterial coatings are still required to provide effective and safe antibacterial nanoparticles. In this study, we developed a plug-in system comprising a spark plasma reactor and a flow heater under nitrogen gas flow to supply precursor inorganic nanoparticles (Cu-Te configuration) that can be modulated in-flight at different temperatures. From antibacterial and toxicological assays in both in vitro and in vivo models, bactericidal and toxicological profiles showed that the plug-in system-based platform can be used to identify key parameters for producing safe-by-design agents with antibacterial activity [>88{\%} (in vitro) and >80{\%} (in vivo) in antibacterial efficiency] and safety (>65{\%} in in vitro viability and >60{\%} in in vivo survival rate).",
author = "Milan Gautam and Park, {Dae Hoon} and Park, {Sung Jae} and Nam, {Kang Sik} and Park, {Geun Young} and Jungho Hwang and Yong, {Chul Soon} and Kim, {Jong Oh} and Byeon, {Jeong Hoon}",
year = "2019",
month = "11",
day = "26",
doi = "10.1021/acsnano.9b04939",
language = "English",
volume = "13",
pages = "12798--12809",
journal = "ACS Nano",
issn = "1936-0851",
publisher = "American Chemical Society",
number = "11",

}

Gautam, M, Park, DH, Park, SJ, Nam, KS, Park, GY, Hwang, J, Yong, CS, Kim, JO & Byeon, JH 2019, 'Plug-In Safe-by-Design Nanoinorganic Antibacterials', ACS Nano, vol. 13, no. 11, pp. 12798-12809. https://doi.org/10.1021/acsnano.9b04939

Plug-In Safe-by-Design Nanoinorganic Antibacterials. / Gautam, Milan; Park, Dae Hoon; Park, Sung Jae; Nam, Kang Sik; Park, Geun Young; Hwang, Jungho; Yong, Chul Soon; Kim, Jong Oh; Byeon, Jeong Hoon.

In: ACS Nano, Vol. 13, No. 11, 26.11.2019, p. 12798-12809.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Plug-In Safe-by-Design Nanoinorganic Antibacterials

AU - Gautam, Milan

AU - Park, Dae Hoon

AU - Park, Sung Jae

AU - Nam, Kang Sik

AU - Park, Geun Young

AU - Hwang, Jungho

AU - Yong, Chul Soon

AU - Kim, Jong Oh

AU - Byeon, Jeong Hoon

PY - 2019/11/26

Y1 - 2019/11/26

N2 - Due to antimicrobial resistance and the adverse health effects that follow broad and inappropriate use of antibacterial agents, new classes of antibacterials with broad and strong bactericidal activity and safety for human use are urgently required globally, increasingly so with the onset of climate change. However, R&D in this field is known to be rarely profitable, unless a cost-effective, flexible, and convenient platform that ensures the production of workable candidate antibacterials can be developed. To address this issue, inorganic nanomaterials have been considered for their bactericidal activities, yet further investigations of composition crystalline modifications and/or surface biomaterial coatings are still required to provide effective and safe antibacterial nanoparticles. In this study, we developed a plug-in system comprising a spark plasma reactor and a flow heater under nitrogen gas flow to supply precursor inorganic nanoparticles (Cu-Te configuration) that can be modulated in-flight at different temperatures. From antibacterial and toxicological assays in both in vitro and in vivo models, bactericidal and toxicological profiles showed that the plug-in system-based platform can be used to identify key parameters for producing safe-by-design agents with antibacterial activity [>88% (in vitro) and >80% (in vivo) in antibacterial efficiency] and safety (>65% in in vitro viability and >60% in in vivo survival rate).

AB - Due to antimicrobial resistance and the adverse health effects that follow broad and inappropriate use of antibacterial agents, new classes of antibacterials with broad and strong bactericidal activity and safety for human use are urgently required globally, increasingly so with the onset of climate change. However, R&D in this field is known to be rarely profitable, unless a cost-effective, flexible, and convenient platform that ensures the production of workable candidate antibacterials can be developed. To address this issue, inorganic nanomaterials have been considered for their bactericidal activities, yet further investigations of composition crystalline modifications and/or surface biomaterial coatings are still required to provide effective and safe antibacterial nanoparticles. In this study, we developed a plug-in system comprising a spark plasma reactor and a flow heater under nitrogen gas flow to supply precursor inorganic nanoparticles (Cu-Te configuration) that can be modulated in-flight at different temperatures. From antibacterial and toxicological assays in both in vitro and in vivo models, bactericidal and toxicological profiles showed that the plug-in system-based platform can be used to identify key parameters for producing safe-by-design agents with antibacterial activity [>88% (in vitro) and >80% (in vivo) in antibacterial efficiency] and safety (>65% in in vitro viability and >60% in in vivo survival rate).

UR - http://www.scopus.com/inward/record.url?scp=85075051911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075051911&partnerID=8YFLogxK

U2 - 10.1021/acsnano.9b04939

DO - 10.1021/acsnano.9b04939

M3 - Article

C2 - 31689083

AN - SCOPUS:85075051911

VL - 13

SP - 12798

EP - 12809

JO - ACS Nano

JF - ACS Nano

SN - 1936-0851

IS - 11

ER -

Gautam M, Park DH, Park SJ, Nam KS, Park GY, Hwang J et al. Plug-In Safe-by-Design Nanoinorganic Antibacterials. ACS Nano. 2019 Nov 26;13(11):12798-12809. https://doi.org/10.1021/acsnano.9b04939