A series of podand hosts having suitable cavities for metal cations in virtue of intramolecular interactions between the terminal groups were designed and synthesized. The conformational informations of hosts were obtained by NMR studies including homonuclear NOE difference experiments. Intramolecular interactions between the terminal groups of podand hosts markedly increase binding affinities and selectivities to metal cations.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry