Podand ionophores capable of forming cation-binding cavities through intramolecular interactions between the terminal groups

Kyu Sung Jeong, Young Lag Cho, Seung Yup Pyun

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Abstract

A series of podand hosts having suitable cavities for metal cations in virtue of intramolecular interactions between the terminal groups were designed and synthesized. The conformational informations of hosts were obtained by NMR studies including homonuclear NOE difference experiments. Intramolecular interactions between the terminal groups of podand hosts markedly increase binding affinities and selectivities to metal cations.

Original languageEnglish
Pages (from-to)2827-2830
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number16
DOIs
Publication statusPublished - 1995 Apr 17

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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