Podocyte biology in diabetic nephropathy

J. J. Li, S. J. Kwak, D. S. Jung, J. J. Kim, TaeHyun Yoo, D. R. Ryu, SeungHyeok Han, H. Y. Choi, Jongeun Lee, S. J. Moon, D. K. Kim, D. S. Han, Shin-Wook Kang

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Glomerular visceral epithelial cells, namely podocytes, are highly specialized cells and give rise to primary processes, secondary processes, and finally foot processes. The foot processes of neighboring podocytes interdigitate, leaving between them filtration slits. These are bridged by an extracellular substance, known as the slit diaphragm, which plays a major role in establishing size-selective barrier to protein loss. Furthermore, podocytes are known to synthesize matrix molecules to the glomerular basement membrane (GBM), including type IV collagen, laminin, entactin, and agrin. Because diabetic nephropathy is clinically characterized by proteinuria and pathologically by glomerular hypertrophy and GBM thickening with foot process effacement, podocytes have been the focus in the field of research on diabetic nephropathy. As a result, many investigations have demonstrated that the diabetic milieu per se, hemodynamic changes, and local growth factors such as transforming growth factor-β and angiotensin II, which are considered mediators in the pathogenesis of diabetic nephropathy, induce directly and/or indirectly hypertrophy, apoptosis, and structural changes, and increase type IV collagen synthesis in podocytes. This review explores some of the structural and functional changes of podocytes under diabetic conditions and their role in the development and progression of diabetic nephropathy.

Original languageEnglish
JournalKidney International
Volume72
Issue numberSUPPL. 106
DOIs
Publication statusPublished - 2007 Aug 1

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Podocytes
Diabetic Nephropathies
Foot
Glomerular Basement Membrane
Collagen Type IV
Hypertrophy
Agrin
Transforming Growth Factors
Laminin
Diaphragm
Proteinuria
Angiotensin II
Intercellular Signaling Peptides and Proteins
Hemodynamics
Apoptosis
Research

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Li, J. J., Kwak, S. J., Jung, D. S., Kim, J. J., Yoo, T., Ryu, D. R., ... Kang, S-W. (2007). Podocyte biology in diabetic nephropathy. Kidney International, 72(SUPPL. 106). https://doi.org/10.1038/sj.ki.5002384
Li, J. J. ; Kwak, S. J. ; Jung, D. S. ; Kim, J. J. ; Yoo, TaeHyun ; Ryu, D. R. ; Han, SeungHyeok ; Choi, H. Y. ; Lee, Jongeun ; Moon, S. J. ; Kim, D. K. ; Han, D. S. ; Kang, Shin-Wook. / Podocyte biology in diabetic nephropathy. In: Kidney International. 2007 ; Vol. 72, No. SUPPL. 106.
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Li, JJ, Kwak, SJ, Jung, DS, Kim, JJ, Yoo, T, Ryu, DR, Han, S, Choi, HY, Lee, J, Moon, SJ, Kim, DK, Han, DS & Kang, S-W 2007, 'Podocyte biology in diabetic nephropathy', Kidney International, vol. 72, no. SUPPL. 106. https://doi.org/10.1038/sj.ki.5002384

Podocyte biology in diabetic nephropathy. / Li, J. J.; Kwak, S. J.; Jung, D. S.; Kim, J. J.; Yoo, TaeHyun; Ryu, D. R.; Han, SeungHyeok; Choi, H. Y.; Lee, Jongeun; Moon, S. J.; Kim, D. K.; Han, D. S.; Kang, Shin-Wook.

In: Kidney International, Vol. 72, No. SUPPL. 106, 01.08.2007.

Research output: Contribution to journalArticle

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AU - Han, D. S.

AU - Kang, Shin-Wook

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Li JJ, Kwak SJ, Jung DS, Kim JJ, Yoo T, Ryu DR et al. Podocyte biology in diabetic nephropathy. Kidney International. 2007 Aug 1;72(SUPPL. 106). https://doi.org/10.1038/sj.ki.5002384