Purpose: To evaluate the point-wise relationships between visual field sensitivity (VFS), as measured by standard automated perimetry (SAP), and macular thickness, as determined by spectral-domain optical coherence tomography (SD-OCT), in patients with glaucoma. Materials and methods: One hundred and six glaucoma subjects (one eye per subject) recruited from an academic institution underwent SAP tests (Humphrey field analyzer, central 24-2 of Swedish Interactive Thresholding Algorithm standard) and SD-OCT volume scans (SPECTRALIS, posterior pole asymmetry analysis). The retinal sensitivities of 16 central test points from the SAP results were recorded. Macular thickness values from 4 square cells in an 8×8 posterior pole retinal thickness map were averaged for a mean retinal thickness (MRT) value, which corresponded to the 16 central test points in the SAP. In each 16-point area, linear regression analyses of the VFS and the MRT value were performed. Results: The VFS of each 16 central test point showed a significant relationship with the corresponding MRT values (R2=0.133-0.383, all p<0.001). Central and nasal test points corresponding to an arcuate region revealed a relatively strong correlation in both the superior and inferior hemispheres (R2=0.311- 0.383 and 0.288-0.345, respectively), but the superior and inferior-temporal points revealed a relatively weaker correlation (R2=0.149 and 0.133, respectively). Conclusions: The VFS showed a significant reciprocal relationship with corresponding macular thickness at each test point. However, the level of the relationship varied among different macular sectors, showing the strongest relationship in the arcuate region.
All Science Journal Classification (ASJC) codes
- Sensory Systems
- Cellular and Molecular Neuroscience