Polarization-extinction-based detection of DNA hybridization in situ using a nanoparticle wire-grid polarizer

Hojeong Yu, Youngjin Oh, Soowon Kim, Seok Ho Song, Donghyun Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Metallic wires can discriminate light polarization due to strong absorption of electric fields oscillating in parallel to wires. Here, we explore polarization-based biosensing of DNA hybridization in situ by employing metal targetconjugated nanoparticles to form a wire-grid polarizer (WGP) as complementary DNA strands hybridize. Experimental results using gold nanoparticles of 15 nm diameter to form a WGP of 400 nm period suggest that polarization extinction can detect DNA hybridization with a limit of detection in the range of 1 nM concentration. The sensitivity may be improved by more than an order of magnitude if larger nanoparticles are employed to define WGPs at a period between 400 and 500 nm.

Original languageEnglish
Pages (from-to)3867-3869
Number of pages3
JournalOptics Letters
Volume37
Issue number18
DOIs
Publication statusPublished - 2012 Sep 15

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics

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