Pollen-Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells

Carmen C. Mayorga-Martinez, Michaela Fojtů, Jan Vyskočil, Nam Joon Cho, Martin Pumera

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Naturally occurring micro/nanoparticles provide an incredible array of potential sources when preparing hybrid micro/nanorobots and their intrinsic properties can be exploited as multitasking functionalities of modern robotics as well as ensuring their mass production availability. Herein, magnetic biological bots (BioBots) prepared from defatted sunflower pollen microparticles by ferromagnetic metal layer evaporation on one side of its surface are described. It is demonstrated that the methodology employed introduces magnetic properties to sunflower pollen microparticles-based BioBots and enable their magnetic actuation. Interestingly, as-prepared magnetic sunflower pollen-based BioBots can naturally attract cancer cells due to their opposite charges (positive and negative, respectively). Such attracted cancer cells can then be transported by microrobots. This strong attraction also allows the delivery of drugs intended to kill the cancer cells. Sunflower-based BioBots can be fabricated in large quantities, and are naturally programmable, making them promising candidates for cancer cell therapy.

Original languageEnglish
Article number2207272
JournalAdvanced Functional Materials
Volume32
Issue number46
DOIs
Publication statusPublished - 2022 Nov 10

Bibliographical note

Funding Information:
This work was supported by the project “Advanced Functional Nanorobots” (reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR), the Ministry of Health of the Czech Republic (NU21‐08‐00407), and Ministry of Education, Youth and Sports (Czech Republic) grant LL2002 under ERC CZ program.

Publisher Copyright:
© 2022 Wiley-VCH GmbH.

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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